Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway

One new (1) and two known angular-type (2,3) furocoumarins, isoarchangelicin (1), archangelicin (2), and 2′-angeloyl-3′-isovaleryl vaginate (3), were isolated from the roots of Angelica atropurpurea. The structure of the new compound was established on the basis of one- and two-dimensional NMR spect...

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Veröffentlicht in:	Natural product communications 2014-12, Vol.9 (12), p.1733-1736
Hauptverfasser:	Nagasawa, Azumi, Sakasai, Mitsuyoshi, Sakaguchi, Daishi, Moriwaki, Shigeru, Nishizawa, Yoshinori, Kitahara, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angelica - chemistry Dose-Response Relationship, Drug Furocoumarins - isolation & purification Furocoumarins - pharmacology Humans Magnetic Resonance Spectroscopy NFATC Transcription Factors - antagonists & inhibitors Plant Roots - chemistry Signal Transduction - drug effects
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