Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway

One new (1) and two known angular-type (2,3) furocoumarins, isoarchangelicin (1), archangelicin (2), and 2′-angeloyl-3′-isovaleryl vaginate (3), were isolated from the roots of Angelica atropurpurea. The structure of the new compound was established on the basis of one- and two-dimensional NMR spect...

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Veröffentlicht in:Natural product communications 2014-12, Vol.9 (12), p.1733-1736
Hauptverfasser: Nagasawa, Azumi, Sakasai, Mitsuyoshi, Sakaguchi, Daishi, Moriwaki, Shigeru, Nishizawa, Yoshinori, Kitahara, Takashi
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container_end_page 1736
container_issue 12
container_start_page 1733
container_title Natural product communications
container_volume 9
creator Nagasawa, Azumi
Sakasai, Mitsuyoshi
Sakaguchi, Daishi
Moriwaki, Shigeru
Nishizawa, Yoshinori
Kitahara, Takashi
description One new (1) and two known angular-type (2,3) furocoumarins, isoarchangelicin (1), archangelicin (2), and 2′-angeloyl-3′-isovaleryl vaginate (3), were isolated from the roots of Angelica atropurpurea. The structure of the new compound was established on the basis of one- and two-dimensional NMR spectra and other spectroscopic studies. The inhibitory activity of these three compounds and a deacylated form of archangelicin (4) on the nuclear factor of activated T cells (NFAT) signal transduction pathway was tested by NFAT-responsive luciferase reporter gene assay in cultured cells. Although 4 did not exhibit inhibitory activity on NFAT signaling, 1–3 exhibited dose-dependent inhibition with IC50 values of 16.5 (1), 9.0 (2), and 9.2 (3) μM.
doi_str_mv 10.1177/1934578X1400901218
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source Sage Journals GOLD Open Access 2024
subjects Angelica - chemistry
Dose-Response Relationship, Drug
Furocoumarins - isolation & purification
Furocoumarins - pharmacology
Humans
Magnetic Resonance Spectroscopy
NFATC Transcription Factors - antagonists & inhibitors
Plant Roots - chemistry
Signal Transduction - drug effects
title Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway
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