Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter

Key points Nitric oxide (NO) is an important inhibitory neurotransmitter in the gastrointestinal tract. Oesophageal achalasia may result from impairment of nitrergic relaxation. Smooth muscle cells (SMCs) have been accepted to be the major targets for neuronal NO to mediate relaxation. However, besi...

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Veröffentlicht in:The Journal of physiology 2015-01, Vol.593 (2), p.403-414
Hauptverfasser: Groneberg, Dieter, Zizer, Eugen, Lies, Barbara, Seidler, Barbara, Saur, Dieter, Wagner, Martin, Friebe, Andreas
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Sprache:eng
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