Computer-Aided Structure-Based Design of Multitarget Leads for Alzheimer’s Disease

Alzheimer’s disease is a neurodegenerative pathology with unmet clinical needs. A highly desirable approach to this syndrome would be to find a single lead that could bind to some or all of the selected biomolecules that participate in the amyloid cascade, the most accepted route for Alzheimer disea...

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Veröffentlicht in:	Journal of chemical information and modeling 2015-01, Vol.55 (1), p.135-148
Hauptverfasser:	Domínguez, José L, Fernández-Nieto, Fernando, Castro, Marian, Catto, Marco, Paleo, M. Rita, Porto, Silvia, Sardina, F. Javier, Brea, José M, Carotti, Angelo, Villaverde, M. Carmen, Sussman, Fredy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Acetylcholinesterase - metabolism Alzheimer Disease - drug therapy Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases - chemistry Amyloid Precursor Protein Secretases - metabolism Analytical chemistry Aspartic Acid Endopeptidases - chemistry Aspartic Acid Endopeptidases - metabolism Binding Sites Carbazoles - chemistry Carbazoles - pharmacology Chemical compounds Chemical synthesis Chemistry Techniques, Synthetic Computer-Aided Design Drug Design Drug Evaluation, Preclinical - methods Humans Indoles - chemistry Indoles - pharmacology Ligands Molecular Dynamics Simulation Molecular structure Molecular Targeted Therapy Peptide Fragments - antagonists & inhibitors Peptide Fragments - metabolism
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