Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis

Abstract We have explored the beneficial effects of retinoic acid (RA) on B cells from multiple sclerosis (MS) patients. When co-stimulated via the toll-like receptors (TLRs) TLR9 and RP105, MS B cells secreted less of the anti-inflammatory cytokine interleukin 10 (IL-10) compared to B cells from he...

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Veröffentlicht in:	Journal of neuroimmunology 2015-01, Vol.278, p.11-18
Hauptverfasser:	Eriksen, Agnete Bratsberg, Berge, Tone, Gustavsen, Marte Wendel, Leikfoss, Ingvild Sørum, Bos, Steffan Daniel, Spurkland, Anne, Harbo, Hanne F, Blomhoff, Heidi Kiil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergy and Immunology Antigens, CD - pharmacology Antigens, CD19 - metabolism B cells B-Lymphocytes - drug effects B-Lymphocytes - metabolism Cell Proliferation - drug effects Cells, Cultured Female Glatiramer Acetate Humans IL-10 Immunosuppressive Agents - pharmacology Interleukin-10 - metabolism Keratolytic Agents - pharmacology Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - pathology Neurology Peptides - pharmacology Retinoic acid TLR TNF-α Toll-Like Receptor 9 - metabolism Tretinoin - pharmacology Tumor Necrosis Factor-alpha - metabolism
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