Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis
Abstract We have explored the beneficial effects of retinoic acid (RA) on B cells from multiple sclerosis (MS) patients. When co-stimulated via the toll-like receptors (TLRs) TLR9 and RP105, MS B cells secreted less of the anti-inflammatory cytokine interleukin 10 (IL-10) compared to B cells from he...
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| Veröffentlicht in: | Journal of neuroimmunology 2015-01, Vol.278, p.11-18 |
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| creator | Eriksen, Agnete Bratsberg Berge, Tone Gustavsen, Marte Wendel Leikfoss, Ingvild Sørum Bos, Steffan Daniel Spurkland, Anne Harbo, Hanne F Blomhoff, Heidi Kiil |
| description | Abstract We have explored the beneficial effects of retinoic acid (RA) on B cells from multiple sclerosis (MS) patients. When co-stimulated via the toll-like receptors (TLRs) TLR9 and RP105, MS B cells secreted less of the anti-inflammatory cytokine interleukin 10 (IL-10) compared to B cells from healthy controls. Importantly, RA enhanced the secretion of IL-10 by MS-derived B cells without affecting the levels of the pro-inflammatory cytokine TNF-α. RA revealed the same ability to induce IL-10 as did interferon-β-1b (IFN-β-1b), and B-cells from patients treated with glatiramer acetate or IFN-β-1b still displayed the beneficial effects of RA on the IL-10/TNF-α ratio. |
| doi_str_mv | 10.1016/j.jneuroim.2014.11.019 |
| format | Article |
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When co-stimulated via the toll-like receptors (TLRs) TLR9 and RP105, MS B cells secreted less of the anti-inflammatory cytokine interleukin 10 (IL-10) compared to B cells from healthy controls. Importantly, RA enhanced the secretion of IL-10 by MS-derived B cells without affecting the levels of the pro-inflammatory cytokine TNF-α. RA revealed the same ability to induce IL-10 as did interferon-β-1b (IFN-β-1b), and B-cells from patients treated with glatiramer acetate or IFN-β-1b still displayed the beneficial effects of RA on the IL-10/TNF-α ratio.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2014.11.019</identifier><identifier>PMID: 25595247</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Allergy and Immunology ; Antigens, CD - pharmacology ; Antigens, CD19 - metabolism ; B cells ; B-Lymphocytes - drug effects ; B-Lymphocytes - metabolism ; Cell Proliferation - drug effects ; Cells, Cultured ; Female ; Glatiramer Acetate ; Humans ; IL-10 ; Immunosuppressive Agents - pharmacology ; Interleukin-10 - metabolism ; Keratolytic Agents - pharmacology ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis, Relapsing-Remitting - pathology ; Neurology ; Peptides - pharmacology ; Retinoic acid ; TLR ; TNF-α ; Toll-Like Receptor 9 - metabolism ; Tretinoin - pharmacology ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Journal of neuroimmunology, 2015-01, Vol.278, p.11-18</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-f407eb0e992b5305c5a93a16d7b75f3b60754d232172b8cf2247fa13b47204d23</citedby><cites>FETCH-LOGICAL-c423t-f407eb0e992b5305c5a93a16d7b75f3b60754d232172b8cf2247fa13b47204d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572814009801$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25595247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eriksen, Agnete Bratsberg</creatorcontrib><creatorcontrib>Berge, Tone</creatorcontrib><creatorcontrib>Gustavsen, Marte Wendel</creatorcontrib><creatorcontrib>Leikfoss, Ingvild Sørum</creatorcontrib><creatorcontrib>Bos, Steffan Daniel</creatorcontrib><creatorcontrib>Spurkland, Anne</creatorcontrib><creatorcontrib>Harbo, Hanne F</creatorcontrib><creatorcontrib>Blomhoff, Heidi Kiil</creatorcontrib><title>Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract We have explored the beneficial effects of retinoic acid (RA) on B cells from multiple sclerosis (MS) patients. When co-stimulated via the toll-like receptors (TLRs) TLR9 and RP105, MS B cells secreted less of the anti-inflammatory cytokine interleukin 10 (IL-10) compared to B cells from healthy controls. Importantly, RA enhanced the secretion of IL-10 by MS-derived B cells without affecting the levels of the pro-inflammatory cytokine TNF-α. RA revealed the same ability to induce IL-10 as did interferon-β-1b (IFN-β-1b), and B-cells from patients treated with glatiramer acetate or IFN-β-1b still displayed the beneficial effects of RA on the IL-10/TNF-α ratio.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Antigens, CD - pharmacology</subject><subject>Antigens, CD19 - metabolism</subject><subject>B cells</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - metabolism</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Female</subject><subject>Glatiramer Acetate</subject><subject>Humans</subject><subject>IL-10</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Interleukin-10 - metabolism</subject><subject>Keratolytic Agents - pharmacology</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - pathology</subject><subject>Neurology</subject><subject>Peptides - pharmacology</subject><subject>Retinoic acid</subject><subject>TLR</subject><subject>TNF-α</subject><subject>Toll-Like Receptor 9 - metabolism</subject><subject>Tretinoin - pharmacology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktu1TAUhi0EopfCFioPmSTYjh0nEwRUPCpdCamUseU4J70OjhNsp1Vn3QM7ZCU4ui0DJow88Pefx6eD0BklJSW0fjOWo4c1zHYqGaG8pLQktH2CdrSRrGg4o0_RLoOiEJI1J-hFjCMhVFS8fY5OmBCtYFzu0P0lJOtna7A2tsfgD9obiDgdADu4ARfxPOCLfUEJth5f7S-LmOy0Op2gxx-wAZeRIcwTXnSy4FPEtzYdcACnl2j99e_7XwEmm3Kba5yDyS4OcDQOwhxtfImeDdpFePXwnqLvnz5enX8p9l8_X5y_3xeGsyoVAycSOgJtyzpREWGEbitN6152UgxVVxMpeM8qRiXrGjOwvN2gadVxycj2cYpeH-suYf65QkxqsnGbXnuY16iyKsaZrKXMaH1ETZ4wBhjUEuykw52iRG321age7avNvqJUZfs5ePbQY-0m6P_GHnVn4N0RyF7hxkJQ0WRnBnobwCTVz_b_Pd7-U8I4663R7gfcQRznNfjsUVEVmSLq23YD2wlQTkjbEFr9AZKWsB4</recordid><startdate>20150115</startdate><enddate>20150115</enddate><creator>Eriksen, Agnete Bratsberg</creator><creator>Berge, Tone</creator><creator>Gustavsen, Marte Wendel</creator><creator>Leikfoss, Ingvild Sørum</creator><creator>Bos, Steffan Daniel</creator><creator>Spurkland, Anne</creator><creator>Harbo, Hanne F</creator><creator>Blomhoff, Heidi Kiil</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150115</creationdate><title>Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis</title><author>Eriksen, Agnete Bratsberg ; Berge, Tone ; Gustavsen, Marte Wendel ; Leikfoss, Ingvild Sørum ; Bos, Steffan Daniel ; Spurkland, Anne ; Harbo, Hanne F ; Blomhoff, Heidi Kiil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-f407eb0e992b5305c5a93a16d7b75f3b60754d232172b8cf2247fa13b47204d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Antigens, CD - pharmacology</topic><topic>Antigens, CD19 - metabolism</topic><topic>B cells</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - metabolism</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Female</topic><topic>Glatiramer Acetate</topic><topic>Humans</topic><topic>IL-10</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Interleukin-10 - metabolism</topic><topic>Keratolytic Agents - pharmacology</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - pathology</topic><topic>Neurology</topic><topic>Peptides - pharmacology</topic><topic>Retinoic acid</topic><topic>TLR</topic><topic>TNF-α</topic><topic>Toll-Like Receptor 9 - metabolism</topic><topic>Tretinoin - pharmacology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eriksen, Agnete Bratsberg</creatorcontrib><creatorcontrib>Berge, Tone</creatorcontrib><creatorcontrib>Gustavsen, Marte Wendel</creatorcontrib><creatorcontrib>Leikfoss, Ingvild Sørum</creatorcontrib><creatorcontrib>Bos, Steffan Daniel</creatorcontrib><creatorcontrib>Spurkland, Anne</creatorcontrib><creatorcontrib>Harbo, Hanne F</creatorcontrib><creatorcontrib>Blomhoff, Heidi Kiil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eriksen, Agnete Bratsberg</au><au>Berge, Tone</au><au>Gustavsen, Marte Wendel</au><au>Leikfoss, Ingvild Sørum</au><au>Bos, Steffan Daniel</au><au>Spurkland, Anne</au><au>Harbo, Hanne F</au><au>Blomhoff, Heidi Kiil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2015-01-15</date><risdate>2015</risdate><volume>278</volume><spage>11</spage><epage>18</epage><pages>11-18</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract We have explored the beneficial effects of retinoic acid (RA) on B cells from multiple sclerosis (MS) patients. When co-stimulated via the toll-like receptors (TLRs) TLR9 and RP105, MS B cells secreted less of the anti-inflammatory cytokine interleukin 10 (IL-10) compared to B cells from healthy controls. Importantly, RA enhanced the secretion of IL-10 by MS-derived B cells without affecting the levels of the pro-inflammatory cytokine TNF-α. RA revealed the same ability to induce IL-10 as did interferon-β-1b (IFN-β-1b), and B-cells from patients treated with glatiramer acetate or IFN-β-1b still displayed the beneficial effects of RA on the IL-10/TNF-α ratio.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25595247</pmid><doi>10.1016/j.jneuroim.2014.11.019</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Allergy and Immunology Antigens, CD - pharmacology Antigens, CD19 - metabolism B cells B-Lymphocytes - drug effects B-Lymphocytes - metabolism Cell Proliferation - drug effects Cells, Cultured Female Glatiramer Acetate Humans IL-10 Immunosuppressive Agents - pharmacology Interleukin-10 - metabolism Keratolytic Agents - pharmacology Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - pathology Neurology Peptides - pharmacology Retinoic acid TLR TNF-α Toll-Like Receptor 9 - metabolism Tretinoin - pharmacology Tumor Necrosis Factor-alpha - metabolism |
| title | Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing–remitting multiple sclerosis |
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