Magnetic Purification of Curcumin from Curcuma longa Rhizome by Novel Naked Maghemite Nanoparticles
Naked maghemite nanoparticles, namely, surface active maghemite nanoparticles (SAMNs), characterized by a diameter of about 10 nm, possessing peculiar colloidal stability, surface chemistry, and superparamagnetism, present fundamental requisites for the development of effective magnetic purification...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2015-01, Vol.63 (3), p.912-920 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Magro, Massimiliano Campos, Rene Baratella, Davide Ferreira, Maria Izabela Bonaiuto, Emanuela Corraducci, Vittorino Uliana, Maíra Rodrigues Lima, Giuseppina Pace Pereira Santagata, Silvia Sambo, Paolo Vianello, Fabio |
| description | Naked maghemite nanoparticles, namely, surface active maghemite nanoparticles (SAMNs), characterized by a diameter of about 10 nm, possessing peculiar colloidal stability, surface chemistry, and superparamagnetism, present fundamental requisites for the development of effective magnetic purification processes for biomolecules in complex matrices. Polyphenolic molecules presenting functionalities with different proclivities toward iron chelation were studied as probes for testing SAMN suitability for magnetic purification. Thus, the binding efficiency and reversibility on SAMNs of phenolic compounds of interest in the pharmaceutical and food industries, namely, catechin, tyrosine, hydroxytyrosine, ferulic acid, coumaric acid, rosmarinic acid, naringenin, curcumin, and cyanidin-3-glucoside, were evaluated. Curcumin emerged as an elective compound, suitable for magnetic purification by SAMNs from complex matrices. A combination of curcumin, demethoxycurcumin, and bis-demethoxycurcumin was recovered by a single magnetic purification step from extracts of Curcuma longa rhizomes, with a purity >98% and a purification yield of 45%, curcumin being >80% of the total purified curcuminoids. |
| doi_str_mv | 10.1021/jf504624u |
| format | Article |
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Polyphenolic molecules presenting functionalities with different proclivities toward iron chelation were studied as probes for testing SAMN suitability for magnetic purification. Thus, the binding efficiency and reversibility on SAMNs of phenolic compounds of interest in the pharmaceutical and food industries, namely, catechin, tyrosine, hydroxytyrosine, ferulic acid, coumaric acid, rosmarinic acid, naringenin, curcumin, and cyanidin-3-glucoside, were evaluated. Curcumin emerged as an elective compound, suitable for magnetic purification by SAMNs from complex matrices. A combination of curcumin, demethoxycurcumin, and bis-demethoxycurcumin was recovered by a single magnetic purification step from extracts of Curcuma longa rhizomes, with a purity >98% and a purification yield of 45%, curcumin being >80% of the total purified curcuminoids.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf504624u</identifier><identifier>PMID: 25584520</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>catechin ; chelation ; Curcuma - chemistry ; Curcuma longa ; curcumin ; Curcumin - isolation & purification ; Ferric Compounds ; ferulic acid ; food industry ; maghemite ; Magnetic Phenomena ; Nanoparticles ; naringenin ; purification methods ; Rhizome - chemistry ; rhizomes ; rosmarinic acid ; Spectroscopy, Mossbauer ; Surface-Active Agents ; tyrosine</subject><ispartof>Journal of agricultural and food chemistry, 2015-01, Vol.63 (3), p.912-920</ispartof><rights>Copyright © 2015 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a339t-99d542226182af14eda425f6d9723bd0ecbe29e2f85cad2ee8e9796b52101b33</citedby><cites>FETCH-LOGICAL-a339t-99d542226182af14eda425f6d9723bd0ecbe29e2f85cad2ee8e9796b52101b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf504624u$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf504624u$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25584520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magro, Massimiliano</creatorcontrib><creatorcontrib>Campos, Rene</creatorcontrib><creatorcontrib>Baratella, Davide</creatorcontrib><creatorcontrib>Ferreira, Maria Izabela</creatorcontrib><creatorcontrib>Bonaiuto, Emanuela</creatorcontrib><creatorcontrib>Corraducci, Vittorino</creatorcontrib><creatorcontrib>Uliana, Maíra Rodrigues</creatorcontrib><creatorcontrib>Lima, Giuseppina Pace Pereira</creatorcontrib><creatorcontrib>Santagata, Silvia</creatorcontrib><creatorcontrib>Sambo, Paolo</creatorcontrib><creatorcontrib>Vianello, Fabio</creatorcontrib><title>Magnetic Purification of Curcumin from Curcuma longa Rhizome by Novel Naked Maghemite Nanoparticles</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Naked maghemite nanoparticles, namely, surface active maghemite nanoparticles (SAMNs), characterized by a diameter of about 10 nm, possessing peculiar colloidal stability, surface chemistry, and superparamagnetism, present fundamental requisites for the development of effective magnetic purification processes for biomolecules in complex matrices. Polyphenolic molecules presenting functionalities with different proclivities toward iron chelation were studied as probes for testing SAMN suitability for magnetic purification. Thus, the binding efficiency and reversibility on SAMNs of phenolic compounds of interest in the pharmaceutical and food industries, namely, catechin, tyrosine, hydroxytyrosine, ferulic acid, coumaric acid, rosmarinic acid, naringenin, curcumin, and cyanidin-3-glucoside, were evaluated. Curcumin emerged as an elective compound, suitable for magnetic purification by SAMNs from complex matrices. A combination of curcumin, demethoxycurcumin, and bis-demethoxycurcumin was recovered by a single magnetic purification step from extracts of Curcuma longa rhizomes, with a purity >98% and a purification yield of 45%, curcumin being >80% of the total purified curcuminoids.</description><subject>catechin</subject><subject>chelation</subject><subject>Curcuma - chemistry</subject><subject>Curcuma longa</subject><subject>curcumin</subject><subject>Curcumin - isolation & purification</subject><subject>Ferric Compounds</subject><subject>ferulic acid</subject><subject>food industry</subject><subject>maghemite</subject><subject>Magnetic Phenomena</subject><subject>Nanoparticles</subject><subject>naringenin</subject><subject>purification methods</subject><subject>Rhizome - chemistry</subject><subject>rhizomes</subject><subject>rosmarinic acid</subject><subject>Spectroscopy, Mossbauer</subject><subject>Surface-Active Agents</subject><subject>tyrosine</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1P3DAQBmCrKipbyqF_oPiC1B7Sjidx1jmiVb8koFWBs-U448VLEi92gkR_fY124dTTaDSP3pFext4L-CwAxZeNk1DVWM2v2EJIhEIKoV6zBeRjoWQtDtnblDYAoOQS3rBDlFJVGS6YvTDrkSZv-e85euetmXwYeXB8NUc7D37kLoZhvxneh3Ft-J9b_zcMxNtHfhkeqOeX5o46nrNuafAT5X0MWxNzbk_pHTtwpk90vJ9H7Prb1-vVj-L81_efq7PzwpRlMxVN08kKEWuh0DhRUWcqlK7umiWWbQdkW8KG0ClpTYdEipplU7cSBYi2LI_Yx13sNob7mdKkB58s9b0ZKcxJi1pihUsom0w_7aiNIaVITm-jH0x81AL0U6X6pdJsP-xj53ag7kU-d5jByQ44E7RZR5_0zRWCqAEEglIqi9OdMDbpTZjjmGv4z6t_7Y2Gqg</recordid><startdate>20150128</startdate><enddate>20150128</enddate><creator>Magro, Massimiliano</creator><creator>Campos, Rene</creator><creator>Baratella, Davide</creator><creator>Ferreira, Maria Izabela</creator><creator>Bonaiuto, Emanuela</creator><creator>Corraducci, Vittorino</creator><creator>Uliana, Maíra Rodrigues</creator><creator>Lima, Giuseppina Pace Pereira</creator><creator>Santagata, Silvia</creator><creator>Sambo, Paolo</creator><creator>Vianello, Fabio</creator><general>American Chemical Society</general><general>American Chemical Society, Books and Journals Division</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150128</creationdate><title>Magnetic Purification of Curcumin from Curcuma longa Rhizome by Novel Naked Maghemite Nanoparticles</title><author>Magro, Massimiliano ; Campos, Rene ; Baratella, Davide ; Ferreira, Maria Izabela ; Bonaiuto, Emanuela ; Corraducci, Vittorino ; Uliana, Maíra Rodrigues ; Lima, Giuseppina Pace Pereira ; Santagata, Silvia ; Sambo, Paolo ; Vianello, Fabio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a339t-99d542226182af14eda425f6d9723bd0ecbe29e2f85cad2ee8e9796b52101b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>catechin</topic><topic>chelation</topic><topic>Curcuma - chemistry</topic><topic>Curcuma longa</topic><topic>curcumin</topic><topic>Curcumin - isolation & purification</topic><topic>Ferric Compounds</topic><topic>ferulic acid</topic><topic>food industry</topic><topic>maghemite</topic><topic>Magnetic Phenomena</topic><topic>Nanoparticles</topic><topic>naringenin</topic><topic>purification methods</topic><topic>Rhizome - chemistry</topic><topic>rhizomes</topic><topic>rosmarinic acid</topic><topic>Spectroscopy, Mossbauer</topic><topic>Surface-Active Agents</topic><topic>tyrosine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magro, Massimiliano</creatorcontrib><creatorcontrib>Campos, Rene</creatorcontrib><creatorcontrib>Baratella, Davide</creatorcontrib><creatorcontrib>Ferreira, Maria Izabela</creatorcontrib><creatorcontrib>Bonaiuto, Emanuela</creatorcontrib><creatorcontrib>Corraducci, Vittorino</creatorcontrib><creatorcontrib>Uliana, Maíra Rodrigues</creatorcontrib><creatorcontrib>Lima, Giuseppina Pace Pereira</creatorcontrib><creatorcontrib>Santagata, Silvia</creatorcontrib><creatorcontrib>Sambo, Paolo</creatorcontrib><creatorcontrib>Vianello, Fabio</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magro, Massimiliano</au><au>Campos, Rene</au><au>Baratella, Davide</au><au>Ferreira, Maria Izabela</au><au>Bonaiuto, Emanuela</au><au>Corraducci, Vittorino</au><au>Uliana, Maíra Rodrigues</au><au>Lima, Giuseppina Pace Pereira</au><au>Santagata, Silvia</au><au>Sambo, Paolo</au><au>Vianello, Fabio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Purification of Curcumin from Curcuma longa Rhizome by Novel Naked Maghemite Nanoparticles</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2015-01-28</date><risdate>2015</risdate><volume>63</volume><issue>3</issue><spage>912</spage><epage>920</epage><pages>912-920</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Naked maghemite nanoparticles, namely, surface active maghemite nanoparticles (SAMNs), characterized by a diameter of about 10 nm, possessing peculiar colloidal stability, surface chemistry, and superparamagnetism, present fundamental requisites for the development of effective magnetic purification processes for biomolecules in complex matrices. Polyphenolic molecules presenting functionalities with different proclivities toward iron chelation were studied as probes for testing SAMN suitability for magnetic purification. Thus, the binding efficiency and reversibility on SAMNs of phenolic compounds of interest in the pharmaceutical and food industries, namely, catechin, tyrosine, hydroxytyrosine, ferulic acid, coumaric acid, rosmarinic acid, naringenin, curcumin, and cyanidin-3-glucoside, were evaluated. Curcumin emerged as an elective compound, suitable for magnetic purification by SAMNs from complex matrices. A combination of curcumin, demethoxycurcumin, and bis-demethoxycurcumin was recovered by a single magnetic purification step from extracts of Curcuma longa rhizomes, with a purity >98% and a purification yield of 45%, curcumin being >80% of the total purified curcuminoids.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>25584520</pmid><doi>10.1021/jf504624u</doi><tpages>9</tpages></addata></record> |
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| subjects | catechin chelation Curcuma - chemistry Curcuma longa curcumin Curcumin - isolation & purification Ferric Compounds ferulic acid food industry maghemite Magnetic Phenomena Nanoparticles naringenin purification methods Rhizome - chemistry rhizomes rosmarinic acid Spectroscopy, Mossbauer Surface-Active Agents tyrosine |
| title | Magnetic Purification of Curcumin from Curcuma longa Rhizome by Novel Naked Maghemite Nanoparticles |
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