STEP₆₁ is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease

Significance In neurons, STEP ₆₁ (striatal-enriched protein tyrosine phosphatase) protein levels are tightly regulated, and the protein’s up-regulation is implicated in several neuropsychiatric disorders. Here, we demonstrate that parkin is a major E3 ligase regulating STEP ₆₁ levels through the ubi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-01, Vol.112 (4), p.1202-1207
Hauptverfasser:	Kurup, Pradeep K, Xu, Jian, Videira, Rita Alexandra, Ononenyi, Chimezie, Baltazar, Graça, Lombroso, Paul J, Nairn, Angus C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Corpus Striatum - enzymology Corpus Striatum - pathology Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Down-Regulation - genetics Gene Expression Regulation, Enzymologic HEK293 Cells Humans MAP Kinase Signaling System Mice Mice, Knockout Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism MPTP Poisoning - enzymology MPTP Poisoning - genetics MPTP Poisoning - pathology Protein Tyrosine Phosphatases, Non-Receptor - biosynthesis Protein Tyrosine Phosphatases, Non-Receptor - genetics Rats Rats, Sprague-Dawley Ubiquitin-Protein Ligases - biosynthesis Ubiquitin-Protein Ligases - genetics Ubiquitination - genetics Up-Regulation - genetics
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