Adipokine zinc‐α2‐glycoprotein regulated by growth hormone and linked to insulin sensitivity
Objective Hypertrophic obesity is associated with impaired insulin sensitivity and lipid‐mobilizing activity of zinc‐α2‐glycoprotein. Adipose tissue (AT) of growth hormone (GH) ‐deficient patients is characterized by extreme adipocyte hypertrophy due to defects in AT lipid metabolism. It was hypothe...
Gespeichert in:
| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2015-02, Vol.23 (2), p.322-328 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 328 |
|---|---|
| container_issue | 2 |
| container_start_page | 322 |
| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 23 |
| creator | Balaz, Miroslav Ukropcova, Barbara Kurdiova, Timea Gajdosechova, Lucia Vlcek, Miroslav Janakova, Zuzana Fedeles, Jozef Pura, Mikulas Gasperikova, Daniela Smith, Steven R. Tkacova, Ruzena Klimes, Iwar Payer, Juraj Wolfrum, Christian Ukropec, Jozef |
| description | Objective
Hypertrophic obesity is associated with impaired insulin sensitivity and lipid‐mobilizing activity of zinc‐α2‐glycoprotein. Adipose tissue (AT) of growth hormone (GH) ‐deficient patients is characterized by extreme adipocyte hypertrophy due to defects in AT lipid metabolism. It was hypothesized that zinc‐α2‐glycoprotein is regulated by GH and mediates some of its beneficial effects in AT.
Methods
AT from patients with GH deficiency and individuals with obesity‐related GH deficit was obtained before and after 5‐year and 24‐month GH supplementation therapy. GH action was tested in primary human adipocytes. Relationships of GH and zinc‐α2‐glycoprotein with adipocyte size and insulin sensitivity were evaluated in nondiabetic patients with noncancerous cachexia and hypertrophic obesity.
Results
AT in GH‐deficient adults displayed a substantial reduction of zinc‐α2‐glycoprotein. GH therapy normalized AT zinc‐α2‐glycoprotein. Obesity‐related relative GH deficit was associated with almost 80% reduction of zinc‐α2‐glycoprotein mRNA in AT. GH increased zinc‐α2‐glycoprotein mRNA in both AT of obese men and primary human adipocytes. Interdependence of GH and zinc‐α2‐glycoprotein in regulating AT morphology and metabolic phenotype was evident from their relationship with adipocyte size and AT‐specific and whole‐body insulin sensitivity.
Conclusions
The results demonstrate that GH is involved in regulation of AT zinc‐α2‐glycoprotein; however, the molecular mechanism linking GH and zinc‐α2‐glycoprotein in AT is yet unknown. |
| doi_str_mv | 10.1002/oby.20856 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652422882</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652422882</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2066-6c42ec77167022f02660353a933e0321d8146598c0a9b905fe7366ec74a2a6db3</originalsourceid><addsrcrecordid>eNo9kE1OwzAQhS0EoqWw4ALISzZpx3biOMtS8SdV6gYkWEVO4ramqV3ihCqsOAJX4SIcgpNg2tLN_Oh9bzR6CJ0T6BMAOrBZ26cgIn6AuiRhEMQseTrcz4J00IlzLwAhh4gcow6NIBEiirtIDgu9sgttFH7XJv_5-Pz-or7Oyja3q8rWShtcqVlTyloVOGvxrLLreo7ntlpa75KmwKU2Cy_WFmvjGr9hp4zTtX7TdXuKjqaydOps13vo8eb6YXQXjCe396PhOMgpcB7wPKQqj2PCY6B0CpRzYBGTCWMKGCWFICGPEpGDTLIEoqmKGefeEUoqeZGxHrrc3vVfvzbK1elSu1yVpTTKNi4lPKIhpUJQj17s0CZbqiJdVXopqzb9j8UDgy2w1qVq9zqB9C_v1OedbvJOJ1fPm4H9ArHVdUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652422882</pqid></control><display><type>article</type><title>Adipokine zinc‐α2‐glycoprotein regulated by growth hormone and linked to insulin sensitivity</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Balaz, Miroslav ; Ukropcova, Barbara ; Kurdiova, Timea ; Gajdosechova, Lucia ; Vlcek, Miroslav ; Janakova, Zuzana ; Fedeles, Jozef ; Pura, Mikulas ; Gasperikova, Daniela ; Smith, Steven R. ; Tkacova, Ruzena ; Klimes, Iwar ; Payer, Juraj ; Wolfrum, Christian ; Ukropec, Jozef</creator><creatorcontrib>Balaz, Miroslav ; Ukropcova, Barbara ; Kurdiova, Timea ; Gajdosechova, Lucia ; Vlcek, Miroslav ; Janakova, Zuzana ; Fedeles, Jozef ; Pura, Mikulas ; Gasperikova, Daniela ; Smith, Steven R. ; Tkacova, Ruzena ; Klimes, Iwar ; Payer, Juraj ; Wolfrum, Christian ; Ukropec, Jozef</creatorcontrib><description>Objective
Hypertrophic obesity is associated with impaired insulin sensitivity and lipid‐mobilizing activity of zinc‐α2‐glycoprotein. Adipose tissue (AT) of growth hormone (GH) ‐deficient patients is characterized by extreme adipocyte hypertrophy due to defects in AT lipid metabolism. It was hypothesized that zinc‐α2‐glycoprotein is regulated by GH and mediates some of its beneficial effects in AT.
Methods
AT from patients with GH deficiency and individuals with obesity‐related GH deficit was obtained before and after 5‐year and 24‐month GH supplementation therapy. GH action was tested in primary human adipocytes. Relationships of GH and zinc‐α2‐glycoprotein with adipocyte size and insulin sensitivity were evaluated in nondiabetic patients with noncancerous cachexia and hypertrophic obesity.
Results
AT in GH‐deficient adults displayed a substantial reduction of zinc‐α2‐glycoprotein. GH therapy normalized AT zinc‐α2‐glycoprotein. Obesity‐related relative GH deficit was associated with almost 80% reduction of zinc‐α2‐glycoprotein mRNA in AT. GH increased zinc‐α2‐glycoprotein mRNA in both AT of obese men and primary human adipocytes. Interdependence of GH and zinc‐α2‐glycoprotein in regulating AT morphology and metabolic phenotype was evident from their relationship with adipocyte size and AT‐specific and whole‐body insulin sensitivity.
Conclusions
The results demonstrate that GH is involved in regulation of AT zinc‐α2‐glycoprotein; however, the molecular mechanism linking GH and zinc‐α2‐glycoprotein in AT is yet unknown.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20856</identifier><identifier>PMID: 25098857</identifier><language>eng</language><publisher>United States</publisher><subject>Adipocytes - drug effects ; Adipocytes - metabolism ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Administration, Oral ; Adult ; Aged ; Case-Control Studies ; Cohort Studies ; Dietary Supplements ; Female ; Human Growth Hormone - administration & dosage ; Human Growth Hormone - deficiency ; Human Growth Hormone - pharmacology ; Humans ; Lipid Metabolism ; Male ; Middle Aged ; Obesity - metabolism ; Seminal Plasma Proteins - metabolism</subject><ispartof>Obesity (Silver Spring, Md.), 2015-02, Vol.23 (2), p.322-328</ispartof><rights>2014 The Obesity Society</rights><rights>2014 The Obesity Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2066-6c42ec77167022f02660353a933e0321d8146598c0a9b905fe7366ec74a2a6db3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20856$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20856$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25098857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balaz, Miroslav</creatorcontrib><creatorcontrib>Ukropcova, Barbara</creatorcontrib><creatorcontrib>Kurdiova, Timea</creatorcontrib><creatorcontrib>Gajdosechova, Lucia</creatorcontrib><creatorcontrib>Vlcek, Miroslav</creatorcontrib><creatorcontrib>Janakova, Zuzana</creatorcontrib><creatorcontrib>Fedeles, Jozef</creatorcontrib><creatorcontrib>Pura, Mikulas</creatorcontrib><creatorcontrib>Gasperikova, Daniela</creatorcontrib><creatorcontrib>Smith, Steven R.</creatorcontrib><creatorcontrib>Tkacova, Ruzena</creatorcontrib><creatorcontrib>Klimes, Iwar</creatorcontrib><creatorcontrib>Payer, Juraj</creatorcontrib><creatorcontrib>Wolfrum, Christian</creatorcontrib><creatorcontrib>Ukropec, Jozef</creatorcontrib><title>Adipokine zinc‐α2‐glycoprotein regulated by growth hormone and linked to insulin sensitivity</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Hypertrophic obesity is associated with impaired insulin sensitivity and lipid‐mobilizing activity of zinc‐α2‐glycoprotein. Adipose tissue (AT) of growth hormone (GH) ‐deficient patients is characterized by extreme adipocyte hypertrophy due to defects in AT lipid metabolism. It was hypothesized that zinc‐α2‐glycoprotein is regulated by GH and mediates some of its beneficial effects in AT.
Methods
AT from patients with GH deficiency and individuals with obesity‐related GH deficit was obtained before and after 5‐year and 24‐month GH supplementation therapy. GH action was tested in primary human adipocytes. Relationships of GH and zinc‐α2‐glycoprotein with adipocyte size and insulin sensitivity were evaluated in nondiabetic patients with noncancerous cachexia and hypertrophic obesity.
Results
AT in GH‐deficient adults displayed a substantial reduction of zinc‐α2‐glycoprotein. GH therapy normalized AT zinc‐α2‐glycoprotein. Obesity‐related relative GH deficit was associated with almost 80% reduction of zinc‐α2‐glycoprotein mRNA in AT. GH increased zinc‐α2‐glycoprotein mRNA in both AT of obese men and primary human adipocytes. Interdependence of GH and zinc‐α2‐glycoprotein in regulating AT morphology and metabolic phenotype was evident from their relationship with adipocyte size and AT‐specific and whole‐body insulin sensitivity.
Conclusions
The results demonstrate that GH is involved in regulation of AT zinc‐α2‐glycoprotein; however, the molecular mechanism linking GH and zinc‐α2‐glycoprotein in AT is yet unknown.</description><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Human Growth Hormone - administration & dosage</subject><subject>Human Growth Hormone - deficiency</subject><subject>Human Growth Hormone - pharmacology</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - metabolism</subject><subject>Seminal Plasma Proteins - metabolism</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1OwzAQhS0EoqWw4ALISzZpx3biOMtS8SdV6gYkWEVO4ramqV3ihCqsOAJX4SIcgpNg2tLN_Oh9bzR6CJ0T6BMAOrBZ26cgIn6AuiRhEMQseTrcz4J00IlzLwAhh4gcow6NIBEiirtIDgu9sgttFH7XJv_5-Pz-or7Oyja3q8rWShtcqVlTyloVOGvxrLLreo7ntlpa75KmwKU2Cy_WFmvjGr9hp4zTtX7TdXuKjqaydOps13vo8eb6YXQXjCe396PhOMgpcB7wPKQqj2PCY6B0CpRzYBGTCWMKGCWFICGPEpGDTLIEoqmKGefeEUoqeZGxHrrc3vVfvzbK1elSu1yVpTTKNi4lPKIhpUJQj17s0CZbqiJdVXopqzb9j8UDgy2w1qVq9zqB9C_v1OedbvJOJ1fPm4H9ArHVdUA</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Balaz, Miroslav</creator><creator>Ukropcova, Barbara</creator><creator>Kurdiova, Timea</creator><creator>Gajdosechova, Lucia</creator><creator>Vlcek, Miroslav</creator><creator>Janakova, Zuzana</creator><creator>Fedeles, Jozef</creator><creator>Pura, Mikulas</creator><creator>Gasperikova, Daniela</creator><creator>Smith, Steven R.</creator><creator>Tkacova, Ruzena</creator><creator>Klimes, Iwar</creator><creator>Payer, Juraj</creator><creator>Wolfrum, Christian</creator><creator>Ukropec, Jozef</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Adipokine zinc‐α2‐glycoprotein regulated by growth hormone and linked to insulin sensitivity</title><author>Balaz, Miroslav ; Ukropcova, Barbara ; Kurdiova, Timea ; Gajdosechova, Lucia ; Vlcek, Miroslav ; Janakova, Zuzana ; Fedeles, Jozef ; Pura, Mikulas ; Gasperikova, Daniela ; Smith, Steven R. ; Tkacova, Ruzena ; Klimes, Iwar ; Payer, Juraj ; Wolfrum, Christian ; Ukropec, Jozef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2066-6c42ec77167022f02660353a933e0321d8146598c0a9b905fe7366ec74a2a6db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Human Growth Hormone - administration & dosage</topic><topic>Human Growth Hormone - deficiency</topic><topic>Human Growth Hormone - pharmacology</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - metabolism</topic><topic>Seminal Plasma Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balaz, Miroslav</creatorcontrib><creatorcontrib>Ukropcova, Barbara</creatorcontrib><creatorcontrib>Kurdiova, Timea</creatorcontrib><creatorcontrib>Gajdosechova, Lucia</creatorcontrib><creatorcontrib>Vlcek, Miroslav</creatorcontrib><creatorcontrib>Janakova, Zuzana</creatorcontrib><creatorcontrib>Fedeles, Jozef</creatorcontrib><creatorcontrib>Pura, Mikulas</creatorcontrib><creatorcontrib>Gasperikova, Daniela</creatorcontrib><creatorcontrib>Smith, Steven R.</creatorcontrib><creatorcontrib>Tkacova, Ruzena</creatorcontrib><creatorcontrib>Klimes, Iwar</creatorcontrib><creatorcontrib>Payer, Juraj</creatorcontrib><creatorcontrib>Wolfrum, Christian</creatorcontrib><creatorcontrib>Ukropec, Jozef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balaz, Miroslav</au><au>Ukropcova, Barbara</au><au>Kurdiova, Timea</au><au>Gajdosechova, Lucia</au><au>Vlcek, Miroslav</au><au>Janakova, Zuzana</au><au>Fedeles, Jozef</au><au>Pura, Mikulas</au><au>Gasperikova, Daniela</au><au>Smith, Steven R.</au><au>Tkacova, Ruzena</au><au>Klimes, Iwar</au><au>Payer, Juraj</au><au>Wolfrum, Christian</au><au>Ukropec, Jozef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipokine zinc‐α2‐glycoprotein regulated by growth hormone and linked to insulin sensitivity</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2015-02</date><risdate>2015</risdate><volume>23</volume><issue>2</issue><spage>322</spage><epage>328</epage><pages>322-328</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Hypertrophic obesity is associated with impaired insulin sensitivity and lipid‐mobilizing activity of zinc‐α2‐glycoprotein. Adipose tissue (AT) of growth hormone (GH) ‐deficient patients is characterized by extreme adipocyte hypertrophy due to defects in AT lipid metabolism. It was hypothesized that zinc‐α2‐glycoprotein is regulated by GH and mediates some of its beneficial effects in AT.
Methods
AT from patients with GH deficiency and individuals with obesity‐related GH deficit was obtained before and after 5‐year and 24‐month GH supplementation therapy. GH action was tested in primary human adipocytes. Relationships of GH and zinc‐α2‐glycoprotein with adipocyte size and insulin sensitivity were evaluated in nondiabetic patients with noncancerous cachexia and hypertrophic obesity.
Results
AT in GH‐deficient adults displayed a substantial reduction of zinc‐α2‐glycoprotein. GH therapy normalized AT zinc‐α2‐glycoprotein. Obesity‐related relative GH deficit was associated with almost 80% reduction of zinc‐α2‐glycoprotein mRNA in AT. GH increased zinc‐α2‐glycoprotein mRNA in both AT of obese men and primary human adipocytes. Interdependence of GH and zinc‐α2‐glycoprotein in regulating AT morphology and metabolic phenotype was evident from their relationship with adipocyte size and AT‐specific and whole‐body insulin sensitivity.
Conclusions
The results demonstrate that GH is involved in regulation of AT zinc‐α2‐glycoprotein; however, the molecular mechanism linking GH and zinc‐α2‐glycoprotein in AT is yet unknown.</abstract><cop>United States</cop><pmid>25098857</pmid><doi>10.1002/oby.20856</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2015-02, Vol.23 (2), p.322-328 |
| issn | 1930-7381 1930-739X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1652422882 |
| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Adipocytes - drug effects Adipocytes - metabolism Adipose Tissue - drug effects Adipose Tissue - metabolism Administration, Oral Adult Aged Case-Control Studies Cohort Studies Dietary Supplements Female Human Growth Hormone - administration & dosage Human Growth Hormone - deficiency Human Growth Hormone - pharmacology Humans Lipid Metabolism Male Middle Aged Obesity - metabolism Seminal Plasma Proteins - metabolism |
| title | Adipokine zinc‐α2‐glycoprotein regulated by growth hormone and linked to insulin sensitivity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T22%3A11%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adipokine%20zinc%E2%80%90%CE%B12%E2%80%90glycoprotein%20regulated%20by%20growth%20hormone%20and%20linked%20to%20insulin%20sensitivity&rft.jtitle=Obesity%20(Silver%20Spring,%20Md.)&rft.au=Balaz,%20Miroslav&rft.date=2015-02&rft.volume=23&rft.issue=2&rft.spage=322&rft.epage=328&rft.pages=322-328&rft.issn=1930-7381&rft.eissn=1930-739X&rft_id=info:doi/10.1002/oby.20856&rft_dat=%3Cproquest_pubme%3E1652422882%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652422882&rft_id=info:pmid/25098857&rfr_iscdi=true |