Pharmacokinetic comparison of amlodipine adipate/valsartan fixed-dose combination with amlodipine besylate/valsartan fixed-dose combination in healthy volunteers

The aim of this study was to compare pharmacokinetic characteristics of fixed-dose combination (FDC) of two different salt form of amlodipine, amlodipine adipate/valsartan and amlodipine besylate/ valsartan, in healthy Korean volunteers under fasting conditions. A randomized, open-label, single-dose...

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Veröffentlicht in:	International journal of clinical pharmacology and therapeutics 2015-01, Vol.53 (1), p.66-74
Hauptverfasser:	Nam, Ju-Hyun, Oh, Minkyung, Kim, Hyun Ji, Han, Sung Kyun, Kim, Eun Ji, Song, Geun Seog, Kim, Eun-Young, Shin, Jae-Gook, Ghim, Jong-Lyul, Kim, Ho-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amlodipine - administration & dosage Amlodipine - adverse effects Amlodipine - blood Amlodipine - pharmacokinetics Amlodipine, Valsartan Drug Combination Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin II Type 1 Receptor Blockers - adverse effects Angiotensin II Type 1 Receptor Blockers - blood Angiotensin II Type 1 Receptor Blockers - pharmacokinetics Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive Agents - blood Antihypertensive Agents - pharmacokinetics Area Under Curve Asian Continental Ancestry Group Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - adverse effects Calcium Channel Blockers - blood Calcium Channel Blockers - pharmacokinetics Chromatography, Liquid Cross-Over Studies Drug Combinations Half-Life Healthy Volunteers Humans Male Metabolic Clearance Rate Models, Cardiovascular Republic of Korea Tandem Mass Spectrometry Tetrazoles - administration & dosage Tetrazoles - adverse effects Tetrazoles - blood Tetrazoles - pharmacokinetics Therapeutic Equivalency Young Adult
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