Selective prevention of mechanical hyperalgesia after incision by spinal ERK1/2 inhibition

Background Activation of extracellular signal‐regulated kinases (ERK1/2) has been shown to play an important role in several pain states. Here we investigated the ERK1/2 contribution to non‐evoked and evoked pain‐like behaviour in rats after surgical incision. Methods Spinal phosphorylation of ERK1...

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Veröffentlicht in:	European journal of pain 2015-02, Vol.19 (2), p.225-235
Hauptverfasser:	van den Heuvel, I., Reichl, S., Segelcke, D., Zahn, P.K., Pogatzki-Zahn, E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Flavonoids - pharmacology Hyperalgesia - prevention & control Male MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Pain - metabolism Pain Measurement - methods Pain, Postoperative - metabolism Protein Kinase Inhibitors - pharmacology Rats, Sprague-Dawley Spinal Cord - metabolism
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