Dietary polyphenols regulate endothelial function and prevent cardiovascular disease
Abstract Vascular endothelial cell (EC) dysfunction strongly induces development of cardiovascular and cerebrovascular diseases. Epidemiologic studies demonstrated a preventative effect of dietary polyphenols toward cardiovascular disease. In studies using cultured vascular ECs, polyphenols were rec...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015, Vol.31 (1), p.28-37 |
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| creator | Yamagata, Kazuo, Ph.D Tagami, Motoki, M.D Yamori, Yukio, Ph.D., M.D |
| description | Abstract Vascular endothelial cell (EC) dysfunction strongly induces development of cardiovascular and cerebrovascular diseases. Epidemiologic studies demonstrated a preventative effect of dietary polyphenols toward cardiovascular disease. In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production. Furthermore, epigallocatechin-3-gallate inhibited the expression of adhesion molecules by a signaling pathway that is similar to that of high-density lipoprotein and involves induction of Ca2+ /calmodulin-dependent kinase II, liver kinase B, and phosphatidylinositol 3-kinase expression. The effects of polyphenols on ECs include antioxidant activity and enhancement of the expression of several protective proteins, including endothelial nitric oxide synthase and paraoxonase 1. However, the observed effects of dietary polyphenols in vitro do not always translate to an in vivo setting. As such, there are many questions concerning their physiological mode of action. In this review, we discuss research on the effect of dietary polyphenols on cardiovascular disease and their protective effect on EC dysfunction. |
| doi_str_mv | 10.1016/j.nut.2014.04.011 |
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Epidemiologic studies demonstrated a preventative effect of dietary polyphenols toward cardiovascular disease. In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production. Furthermore, epigallocatechin-3-gallate inhibited the expression of adhesion molecules by a signaling pathway that is similar to that of high-density lipoprotein and involves induction of Ca2+ /calmodulin-dependent kinase II, liver kinase B, and phosphatidylinositol 3-kinase expression. The effects of polyphenols on ECs include antioxidant activity and enhancement of the expression of several protective proteins, including endothelial nitric oxide synthase and paraoxonase 1. However, the observed effects of dietary polyphenols in vitro do not always translate to an in vivo setting. As such, there are many questions concerning their physiological mode of action. In this review, we discuss research on the effect of dietary polyphenols on cardiovascular disease and their protective effect on EC dysfunction.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2014.04.011</identifier><identifier>PMID: 25466651</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Oral ; Animals ; Antioxidants ; Apigenin - pharmacology ; Aryldialkylphosphatase - genetics ; Aryldialkylphosphatase - metabolism ; Cardiovascular diseases ; Cardiovascular Diseases - prevention & control ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Diet ; Disease Models, Animal ; Endothelial cells ; Endothelial Cells - drug effects ; Endothelial Cells - metabolism ; Endothelin-1 - genetics ; Endothelin-1 - metabolism ; Epidemiologic study ; Epigallocatechin-3-gallate ; Fruits ; Gastroenterology and Hepatology ; Humans ; Lipoproteins, HDL - metabolism ; Mode of action ; Mortality ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type III - genetics ; Nitric Oxide Synthase Type III - metabolism ; Polyphenol ; Polyphenols ; Polyphenols - pharmacology ; Signal Transduction ; Tea ; U937 Cells</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2015, Vol.31 (1), p.28-37</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-1607b5b7f9da184de4a9710c9c8d193388ae355b151559841ab9c9a24e8e7ad63</citedby><cites>FETCH-LOGICAL-c436t-1607b5b7f9da184de4a9710c9c8d193388ae355b151559841ab9c9a24e8e7ad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0899900714002032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25466651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamagata, Kazuo, Ph.D</creatorcontrib><creatorcontrib>Tagami, Motoki, M.D</creatorcontrib><creatorcontrib>Yamori, Yukio, Ph.D., M.D</creatorcontrib><title>Dietary polyphenols regulate endothelial function and prevent cardiovascular disease</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Vascular endothelial cell (EC) dysfunction strongly induces development of cardiovascular and cerebrovascular diseases. Epidemiologic studies demonstrated a preventative effect of dietary polyphenols toward cardiovascular disease. In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production. Furthermore, epigallocatechin-3-gallate inhibited the expression of adhesion molecules by a signaling pathway that is similar to that of high-density lipoprotein and involves induction of Ca2+ /calmodulin-dependent kinase II, liver kinase B, and phosphatidylinositol 3-kinase expression. The effects of polyphenols on ECs include antioxidant activity and enhancement of the expression of several protective proteins, including endothelial nitric oxide synthase and paraoxonase 1. However, the observed effects of dietary polyphenols in vitro do not always translate to an in vivo setting. As such, there are many questions concerning their physiological mode of action. In this review, we discuss research on the effect of dietary polyphenols on cardiovascular disease and their protective effect on EC dysfunction.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Apigenin - pharmacology</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Aryldialkylphosphatase - metabolism</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - pharmacology</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>Endothelial cells</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelin-1 - genetics</subject><subject>Endothelin-1 - metabolism</subject><subject>Epidemiologic study</subject><subject>Epigallocatechin-3-gallate</subject><subject>Fruits</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Lipoproteins, HDL - metabolism</subject><subject>Mode of action</subject><subject>Mortality</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Nitric Oxide Synthase Type III - metabolism</subject><subject>Polyphenol</subject><subject>Polyphenols</subject><subject>Polyphenols - pharmacology</subject><subject>Signal Transduction</subject><subject>Tea</subject><subject>U937 Cells</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU2LFDEQhoMo7rj6A7xIgxcvPVZ1p7sTBEHWT1jw4HoO6aTGzZhJ2qR7YP69aWZV2INQUJfnfUmeYuw5whYB-9f7bVjmbQPIt1AG8QHboBjaGhvOH7INCClrCTBcsCc57wEAZS8fs4um433fd7hhN-8dzTqdqin603RLIfpcJfqxeD1TRcHG-Za8077aLcHMLoZKB1tNiY4U5sroZF086mxKIFXWZdKZnrJHO-0zPbvbl-z7xw83V5_r66-fvly9u64Nb_u5xh6GsRuHnbQaBbfEtRwQjDTComxbITS1XTdih10nBUc9SiN1w0nQoG3fXrJX594pxV8L5VkdXDbkvQ4Ul6yw7xqOsuQL-vIeuo9LCuV1hWqEAGyBFwrPlEkx50Q7NSV3KHoUglqVq70qytWqXEEZXJtf3DUv44Hs38QfxwV4cwaoqDg6SiobR8GQdYnMrGx0_61_ey9tvAvOaP-TTpT__ULlRoH6tt58PTlygAbapv0NWVymdw</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Yamagata, Kazuo, Ph.D</creator><creator>Tagami, Motoki, M.D</creator><creator>Yamori, Yukio, Ph.D., M.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2015</creationdate><title>Dietary polyphenols regulate endothelial function and prevent cardiovascular disease</title><author>Yamagata, Kazuo, Ph.D ; Tagami, Motoki, M.D ; Yamori, Yukio, Ph.D., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-1607b5b7f9da184de4a9710c9c8d193388ae355b151559841ab9c9a24e8e7ad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Apigenin - 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Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamagata, Kazuo, Ph.D</au><au>Tagami, Motoki, M.D</au><au>Yamori, Yukio, Ph.D., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary polyphenols regulate endothelial function and prevent cardiovascular disease</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2015</date><risdate>2015</risdate><volume>31</volume><issue>1</issue><spage>28</spage><epage>37</epage><pages>28-37</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>Abstract Vascular endothelial cell (EC) dysfunction strongly induces development of cardiovascular and cerebrovascular diseases. Epidemiologic studies demonstrated a preventative effect of dietary polyphenols toward cardiovascular disease. In studies using cultured vascular ECs, polyphenols were recognized to regulate nitric oxide and endothelin-1 (ET-1) production. Furthermore, epigallocatechin-3-gallate inhibited the expression of adhesion molecules by a signaling pathway that is similar to that of high-density lipoprotein and involves induction of Ca2+ /calmodulin-dependent kinase II, liver kinase B, and phosphatidylinositol 3-kinase expression. The effects of polyphenols on ECs include antioxidant activity and enhancement of the expression of several protective proteins, including endothelial nitric oxide synthase and paraoxonase 1. However, the observed effects of dietary polyphenols in vitro do not always translate to an in vivo setting. As such, there are many questions concerning their physiological mode of action. In this review, we discuss research on the effect of dietary polyphenols on cardiovascular disease and their protective effect on EC dysfunction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25466651</pmid><doi>10.1016/j.nut.2014.04.011</doi><tpages>10</tpages></addata></record> |
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| subjects | Administration, Oral Animals Antioxidants Apigenin - pharmacology Aryldialkylphosphatase - genetics Aryldialkylphosphatase - metabolism Cardiovascular diseases Cardiovascular Diseases - prevention & control Catechin - analogs & derivatives Catechin - pharmacology Diet Disease Models, Animal Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelin-1 - genetics Endothelin-1 - metabolism Epidemiologic study Epigallocatechin-3-gallate Fruits Gastroenterology and Hepatology Humans Lipoproteins, HDL - metabolism Mode of action Mortality Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Polyphenol Polyphenols Polyphenols - pharmacology Signal Transduction Tea U937 Cells |
| title | Dietary polyphenols regulate endothelial function and prevent cardiovascular disease |
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