Intralesional Cryotherapy for Treatment of Keloid Scars: A Prospective Study
Intralesional cryotherapy is a novel treatment for keloid scars in which the scar is frozen from inside. Published results are promising, but the treatment has only been tested in a Caucasian patient population. Therefore, the authors evaluated intralesional cryotherapy in a patient population inclu...
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| Veröffentlicht in: | Plastic and reconstructive surgery (1963) 2015-02, Vol.135 (2), p.580-589 |
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| container_title | Plastic and reconstructive surgery (1963) |
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| creator | van Leeuwen, Michiel C. E. van der Wal, Martijn B. A. Bulstra, Anne-Eva J. Galindo-Garre, Francisca Molier, Jonneke van Zuijlen, Paul P. M. van Leeuwen, Paul A. M. Niessen, Frank B. |
| description | Intralesional cryotherapy is a novel treatment for keloid scars in which the scar is frozen from inside. Published results are promising, but the treatment has only been tested in a Caucasian patient population. Therefore, the authors evaluated intralesional cryotherapy in a patient population including different Fitzpatrick skin types (I through VI).
This prospective multicenter study with a 1-year follow-up included 27 patients with 29 keloid scars. Intralesional cryotherapy was administered with a disposable liquid nitrogen-based device called CryoShape. Scar assessment was performed using the Patient and Observer Scar Assessment Scale and four objective devices to determine scar color, scar elasticity, scar volume, and patient skin type.
Keloid scars showed an average volume decrease of 63 percent (range, 16 to 100 percent) after 12 months, compared with baseline (p < 0.01). Recurrence was seen in seven keloids (24 percent) and hypopigmentation recovered in 69 percent of all keloid scars within 12 months. Scar assessment with the Patient and Observer Scar Assessment Scale showed an overall improvement according to both doctors and patients. In addition, complaints of pain and itching were reduced. When analyzing the results per Fitzpatrick skin type, African American patients showed a higher incidence of persistent hypopigmentation (p = 0.02).
Intralesional cryotherapy for the treatment of keloid scars shows favorable results in terms of reduction of volume and complaints of pain and pruritus. However, no complete eradication was obtained in some cases and recurring scars were seen. In addition, persistent hypopigmentation proved a problem in non-Caucasian patients.
Therapeutic, IV. |
| doi_str_mv | 10.1097/PRS.0000000000000911 |
| format | Article |
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This prospective multicenter study with a 1-year follow-up included 27 patients with 29 keloid scars. Intralesional cryotherapy was administered with a disposable liquid nitrogen-based device called CryoShape. Scar assessment was performed using the Patient and Observer Scar Assessment Scale and four objective devices to determine scar color, scar elasticity, scar volume, and patient skin type.
Keloid scars showed an average volume decrease of 63 percent (range, 16 to 100 percent) after 12 months, compared with baseline (p < 0.01). Recurrence was seen in seven keloids (24 percent) and hypopigmentation recovered in 69 percent of all keloid scars within 12 months. Scar assessment with the Patient and Observer Scar Assessment Scale showed an overall improvement according to both doctors and patients. In addition, complaints of pain and itching were reduced. When analyzing the results per Fitzpatrick skin type, African American patients showed a higher incidence of persistent hypopigmentation (p = 0.02).
Intralesional cryotherapy for the treatment of keloid scars shows favorable results in terms of reduction of volume and complaints of pain and pruritus. However, no complete eradication was obtained in some cases and recurring scars were seen. In addition, persistent hypopigmentation proved a problem in non-Caucasian patients.
Therapeutic, IV.</description><identifier>ISSN: 0032-1052</identifier><identifier>ISSN: 1529-4242</identifier><identifier>EISSN: 1529-4242</identifier><identifier>DOI: 10.1097/PRS.0000000000000911</identifier><identifier>PMID: 25626801</identifier><language>eng</language><publisher>United States: American Society of Plastic Surgeons</publisher><subject>Adolescent ; Adult ; Aged ; Asian People ; Black or African American ; Black People ; Child ; Cryosurgery - adverse effects ; Cryosurgery - instrumentation ; Cryosurgery - methods ; Female ; Humans ; Hypopigmentation - etiology ; Injections, Intralesional ; Keloid - complications ; Keloid - therapy ; Male ; Middle Aged ; Needles ; Netherlands ; Nitrogen - administration & dosage ; Nitrogen - therapeutic use ; Pain - etiology ; Postoperative Complications - etiology ; Prospective Studies ; Pruritus - etiology ; Recurrence ; Severity of Illness Index ; Skin Pigmentation ; White People ; Young Adult</subject><ispartof>Plastic and reconstructive surgery (1963), 2015-02, Vol.135 (2), p.580-589</ispartof><rights>American Society of Plastic Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3016-6615c88b9a6cb561eed18cc0cca8de764bce7a093db7d9b6cd8041429590f1eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25626801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Leeuwen, Michiel C. E.</creatorcontrib><creatorcontrib>van der Wal, Martijn B. A.</creatorcontrib><creatorcontrib>Bulstra, Anne-Eva J.</creatorcontrib><creatorcontrib>Galindo-Garre, Francisca</creatorcontrib><creatorcontrib>Molier, Jonneke</creatorcontrib><creatorcontrib>van Zuijlen, Paul P. M.</creatorcontrib><creatorcontrib>van Leeuwen, Paul A. M.</creatorcontrib><creatorcontrib>Niessen, Frank B.</creatorcontrib><title>Intralesional Cryotherapy for Treatment of Keloid Scars: A Prospective Study</title><title>Plastic and reconstructive surgery (1963)</title><addtitle>Plast Reconstr Surg</addtitle><description>Intralesional cryotherapy is a novel treatment for keloid scars in which the scar is frozen from inside. Published results are promising, but the treatment has only been tested in a Caucasian patient population. Therefore, the authors evaluated intralesional cryotherapy in a patient population including different Fitzpatrick skin types (I through VI).
This prospective multicenter study with a 1-year follow-up included 27 patients with 29 keloid scars. Intralesional cryotherapy was administered with a disposable liquid nitrogen-based device called CryoShape. Scar assessment was performed using the Patient and Observer Scar Assessment Scale and four objective devices to determine scar color, scar elasticity, scar volume, and patient skin type.
Keloid scars showed an average volume decrease of 63 percent (range, 16 to 100 percent) after 12 months, compared with baseline (p < 0.01). Recurrence was seen in seven keloids (24 percent) and hypopigmentation recovered in 69 percent of all keloid scars within 12 months. Scar assessment with the Patient and Observer Scar Assessment Scale showed an overall improvement according to both doctors and patients. In addition, complaints of pain and itching were reduced. When analyzing the results per Fitzpatrick skin type, African American patients showed a higher incidence of persistent hypopigmentation (p = 0.02).
Intralesional cryotherapy for the treatment of keloid scars shows favorable results in terms of reduction of volume and complaints of pain and pruritus. However, no complete eradication was obtained in some cases and recurring scars were seen. In addition, persistent hypopigmentation proved a problem in non-Caucasian patients.
Therapeutic, IV.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Asian People</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Child</subject><subject>Cryosurgery - adverse effects</subject><subject>Cryosurgery - instrumentation</subject><subject>Cryosurgery - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Hypopigmentation - etiology</subject><subject>Injections, Intralesional</subject><subject>Keloid - complications</subject><subject>Keloid - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Needles</subject><subject>Netherlands</subject><subject>Nitrogen - administration & dosage</subject><subject>Nitrogen - therapeutic use</subject><subject>Pain - etiology</subject><subject>Postoperative Complications - etiology</subject><subject>Prospective Studies</subject><subject>Pruritus - etiology</subject><subject>Recurrence</subject><subject>Severity of Illness Index</subject><subject>Skin Pigmentation</subject><subject>White People</subject><subject>Young Adult</subject><issn>0032-1052</issn><issn>1529-4242</issn><issn>1529-4242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtLJDEQhYO46Oj6D0Ty6Eu7Vekk3e2bDN7YgZUdfW7S6WqmNTMZk7Qy_972vmxBURScc6r4GDtEOEGoil83f-cn8G9ViFtsgkpUmRRSbLMJQC4yBCV22V6M9wBY5FrtsF2htNAl4ITNrlcpGEex9yvj-DRsfFpQMOsN73zgt4FMWtIqcd_x3-R83_K5NSGe8jN-E3xck039E_F5GtrNT_ajMy7SwcfcZ3cX57fTq2z25_J6ejbLbA6oM61R2bJsKqNtozQStVhaC9aasqVCy8ZSYaDK26Zoq0bbtgSJUlSqgg6pyffZ8XvuOvjHgWKql3205JxZkR9ijVoJiWUuylEq36V2fDYG6up16JcmbGqE-pVjPXKs_-c42o4-LgzNktov0ye479xn7xKF-OCGZwr1goxLi7c8rXKZCUAFYtyysaXOXwDobn1f</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>van Leeuwen, Michiel C. E.</creator><creator>van der Wal, Martijn B. A.</creator><creator>Bulstra, Anne-Eva J.</creator><creator>Galindo-Garre, Francisca</creator><creator>Molier, Jonneke</creator><creator>van Zuijlen, Paul P. M.</creator><creator>van Leeuwen, Paul A. M.</creator><creator>Niessen, Frank B.</creator><general>American Society of Plastic Surgeons</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>Intralesional Cryotherapy for Treatment of Keloid Scars: A Prospective Study</title><author>van Leeuwen, Michiel C. E. ; van der Wal, Martijn B. A. ; Bulstra, Anne-Eva J. ; Galindo-Garre, Francisca ; Molier, Jonneke ; van Zuijlen, Paul P. M. ; van Leeuwen, Paul A. M. ; Niessen, Frank B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3016-6615c88b9a6cb561eed18cc0cca8de764bce7a093db7d9b6cd8041429590f1eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Asian People</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Child</topic><topic>Cryosurgery - adverse effects</topic><topic>Cryosurgery - instrumentation</topic><topic>Cryosurgery - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Hypopigmentation - etiology</topic><topic>Injections, Intralesional</topic><topic>Keloid - complications</topic><topic>Keloid - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Needles</topic><topic>Netherlands</topic><topic>Nitrogen - administration & dosage</topic><topic>Nitrogen - therapeutic use</topic><topic>Pain - etiology</topic><topic>Postoperative Complications - etiology</topic><topic>Prospective Studies</topic><topic>Pruritus - etiology</topic><topic>Recurrence</topic><topic>Severity of Illness Index</topic><topic>Skin Pigmentation</topic><topic>White People</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Leeuwen, Michiel C. E.</creatorcontrib><creatorcontrib>van der Wal, Martijn B. A.</creatorcontrib><creatorcontrib>Bulstra, Anne-Eva J.</creatorcontrib><creatorcontrib>Galindo-Garre, Francisca</creatorcontrib><creatorcontrib>Molier, Jonneke</creatorcontrib><creatorcontrib>van Zuijlen, Paul P. M.</creatorcontrib><creatorcontrib>van Leeuwen, Paul A. M.</creatorcontrib><creatorcontrib>Niessen, Frank B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Plastic and reconstructive surgery (1963)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Leeuwen, Michiel C. E.</au><au>van der Wal, Martijn B. A.</au><au>Bulstra, Anne-Eva J.</au><au>Galindo-Garre, Francisca</au><au>Molier, Jonneke</au><au>van Zuijlen, Paul P. M.</au><au>van Leeuwen, Paul A. M.</au><au>Niessen, Frank B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intralesional Cryotherapy for Treatment of Keloid Scars: A Prospective Study</atitle><jtitle>Plastic and reconstructive surgery (1963)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>135</volume><issue>2</issue><spage>580</spage><epage>589</epage><pages>580-589</pages><issn>0032-1052</issn><issn>1529-4242</issn><eissn>1529-4242</eissn><abstract>Intralesional cryotherapy is a novel treatment for keloid scars in which the scar is frozen from inside. Published results are promising, but the treatment has only been tested in a Caucasian patient population. Therefore, the authors evaluated intralesional cryotherapy in a patient population including different Fitzpatrick skin types (I through VI).
This prospective multicenter study with a 1-year follow-up included 27 patients with 29 keloid scars. Intralesional cryotherapy was administered with a disposable liquid nitrogen-based device called CryoShape. Scar assessment was performed using the Patient and Observer Scar Assessment Scale and four objective devices to determine scar color, scar elasticity, scar volume, and patient skin type.
Keloid scars showed an average volume decrease of 63 percent (range, 16 to 100 percent) after 12 months, compared with baseline (p < 0.01). Recurrence was seen in seven keloids (24 percent) and hypopigmentation recovered in 69 percent of all keloid scars within 12 months. Scar assessment with the Patient and Observer Scar Assessment Scale showed an overall improvement according to both doctors and patients. In addition, complaints of pain and itching were reduced. When analyzing the results per Fitzpatrick skin type, African American patients showed a higher incidence of persistent hypopigmentation (p = 0.02).
Intralesional cryotherapy for the treatment of keloid scars shows favorable results in terms of reduction of volume and complaints of pain and pruritus. However, no complete eradication was obtained in some cases and recurring scars were seen. In addition, persistent hypopigmentation proved a problem in non-Caucasian patients.
Therapeutic, IV.</abstract><cop>United States</cop><pub>American Society of Plastic Surgeons</pub><pmid>25626801</pmid><doi>10.1097/PRS.0000000000000911</doi><tpages>10</tpages></addata></record> |
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| ispartof | Plastic and reconstructive surgery (1963), 2015-02, Vol.135 (2), p.580-589 |
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| subjects | Adolescent Adult Aged Asian People Black or African American Black People Child Cryosurgery - adverse effects Cryosurgery - instrumentation Cryosurgery - methods Female Humans Hypopigmentation - etiology Injections, Intralesional Keloid - complications Keloid - therapy Male Middle Aged Needles Netherlands Nitrogen - administration & dosage Nitrogen - therapeutic use Pain - etiology Postoperative Complications - etiology Prospective Studies Pruritus - etiology Recurrence Severity of Illness Index Skin Pigmentation White People Young Adult |
| title | Intralesional Cryotherapy for Treatment of Keloid Scars: A Prospective Study |
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