CD4+ Natural Killer T Cells Potently Augment Aortic Root Atherosclerosis by Perforin- and Granzyme B-Dependent Cytotoxicity

RATIONALE:CD4 natural killer T (NKT) cells augment atherosclerosis in apolipoprotein E–deficient (ApoE) mice but their mechanisms of action are unknown. OBJECTIVES:We investigated the roles of bystander T, B, and NK cells; NKT cell–derived interferon-γ, interleukin (IL)-4, and IL-21 cytokines; and N...

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Veröffentlicht in:	Circulation research 2015-01, Vol.116 (2), p.245-254
Hauptverfasser:	Li, Yi, To, Kelly, Kanellakis, Peter, Hosseini, Hamid, Deswaerte, Virginie, Tipping, Peter, Smyth, Mark J, Toh, Ban-Hock, Bobik, Alexander, Kyaw, Tin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer - methods Animals Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Granzymes - deficiency Male Mice Mice, Knockout Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Pore Forming Cytotoxic Proteins - deficiency Sinus of Valsalva - immunology Sinus of Valsalva - metabolism Sinus of Valsalva - pathology
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