A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in Mice

Abstract Immunosuppressive pretransplantation conditioning is essential for donor cell engraftment in allogeneic bone marrow transplantation (BMT). The role of residual postconditioning recipient immunity in determining engraftment is poorly understood. We examined the role of recipient perforin in...

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Veröffentlicht in:	Biology of blood and marrow transplantation 2015-02, Vol.21 (2), p.242-249
Hauptverfasser:	Davis, Joanne E, Harvey, Michael, Gherardin, Nicholas A, Koldej, Rachel, Huntington, Nicholas, Neeson, Paul, Trapani, Joseph A, Ritchie, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Transplantation Donor lymphoid cell Engraftment Female Gene Expression Graft Survival Graft vs Host Disease - prevention & control Graft-versus-host disease Hematology, Oncology and Palliative Medicine Host vs Graft Reaction - radiation effects Immunologic Memory Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - radiation effects Lymphocyte Activation Lymphocyte Depletion Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Natural killer cells Perforin Pore Forming Cytotoxic Proteins - deficiency Pore Forming Cytotoxic Proteins - genetics Pore Forming Cytotoxic Proteins - immunology Radiation Tolerance T-Lymphocytes - cytology T-Lymphocytes - immunology Transplantation, Homologous Whole-Body Irradiation
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