Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging – Impact of Bcl-2 and NPD-1 like metabolites

Abstract The present study investigated the effects of orally administered long chain omega-3 polyunsaturated fatty acids (PUFA) on mitochondrial function and processing of the amyloid precursor protein (APP) in brains of young (3 months old) and aged (24 months old) NMRI-mice. Neuroprotective prope...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2015-01, Vol.92, p.23-31
Hauptverfasser:	Afshordel, Sarah, Hagl, Stephanie, Werner, Deborah, Röhner, Nelli, Kögel, Donat, Bazan, Nicolas G, Eckert, Gunter P
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Advanced Basic Science Aging Amyloid beta-Protein Precursor - metabolism Animals Bioenergetics Brain Brain - drug effects Brain - metabolism Brain - physiopathology Cells, Cultured Docosahexaenoic acid Docosahexaenoic Acids - metabolism Endocrinology & Metabolism Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - pharmacology Female Fish oil Membrane Fluidity - drug effects Mice Mitochondria - drug effects Mitochondria - metabolism Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Omega-3 fatty acids Proto-Oncogene Proteins c-bcl-2 - metabolism
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