Cord serum dipeptidyl-peptidase 4 activity in gestational diabetes
Background Tissue‐specific dipeptidyl‐peptidase 4 (DPP4) dysregulation has been described in adults with diabetes mellitus. The DPP4 ‐incretin system has not been studied in foetal life. In this study, DPP4 activity and glucagon‐like peptide‐1 (GLP‐1) levels were assessed in cord blood of neonates b...
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| Veröffentlicht in: | European journal of clinical investigation 2015-02, Vol.45 (2), p.196-203 |
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| creator | Al-Aissa, Zahra Rosta, Klára Hadarits, Orsolya Harreiter, Jürgen Zóka, András Bancher-Todesca, Dagmar Patócs, Attila Kiss, Katalin Sármán, Beatrix Pusztai, Péter Sziller, István Rigó, János Rácz, Károly Somogyi, Anikó Kautzky-Willer, Alexandra Firneisz, Gábor |
| description | Background
Tissue‐specific dipeptidyl‐peptidase 4 (DPP4) dysregulation has been described in adults with diabetes mellitus. The DPP4 ‐incretin system has not been studied in foetal life. In this study, DPP4 activity and glucagon‐like peptide‐1 (GLP‐1) levels were assessed in cord blood of neonates born to women with gestational diabetes mellitus (GDM) and nondiabetic controls.
Material and methods
This study has been conducted in two Hungarian and one Austrian centres. Patients: A total of 568 pregnant women were enrolled in the study after their OGTT between the 24th and 28th gestational week. Cord blood samplings with DPP4 activity and GLP‐1 level measurements were possible in 270 (DPP4: 159 control, 111 GDM) and 112 (GLP‐1: 72 control, 40 GDM) cases. OGTT (24–28th gestational week) and cord blood sampling at delivery were performed. Cord serum DPP4 activity was determined in a continuous monitoring microplate‐based kinetic assay, and cord plasma GLP‐1 was measured using a fluorescence ELISA method.
Results
Cord serum DPP4 activity was lower in GDM [mean (95% CI): 28·07 U/L (26·32–29·82 U/L)] than in controls [31·61 U/L (29·93–33·29 U/L), MWU P = 0·0015]. Cord plasma active GLP‐1 levels were close to the lower detection limit and were not altered in GDM (control: mean = 3·43 pM, 95% CI: 3·04–3·82 pM, GDM: mean = 3·61 pM, 95% CI: 2·96–4·28 pM – MWU test P = 0·6).
Conclusions
Decreased cord serum DPP4 activity in gestational diabetes mellitus might be the result of an adaptive foetal response or an early dysregulation in the entero‐insular axis with consequences beyond the incretin system. Cord plasma GLP‐1 levels may reflect the missing oral intake with a limited glucose sensing of L cells via the circulation in foetal life. |
| doi_str_mv | 10.1111/eci.12397 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652411103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652411103</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3637-b7bb5a7c3c31c6f0d91559ffc7f3caea98836267b5a94a1ba8878deebeb8afb73</originalsourceid><addsrcrecordid>eNp1kLFOwzAQhi0EoqUw8AIoIwxp7TiOkxGi0laqCkhFjJbtXJAhaUqcAHl7DGm7ccvd8P2_Th9ClwSPiZsJaDMmAU34ERoSGjE_oFFwjIYYk9APEh4M0Jm1bxjjmNDgFA0CxljEQjJEd2lVZ56Fui29zGxh25isK_z-kBa80JO6MZ-m6Tyz8V7BNrIx1UYWDpcKGrDn6CSXhYWL3R6h5_vpOp37y4fZIr1d-ppGlPuKK8Uk11RToqMcZwlhLMlzzXOqJcgkjt3XEXdQEkqiZBzzOANQoGKZK05H6Lrv3dbVR-seEaWxGopCbqBqrSARC0KnA1OH3vSoritra8jFtjalrDtBsPhVJpwy8afMsVe72laVkB3IvSMHTHrgyxTQ_d8kpuliX-n3CWMb-D4kZP0uIk45Ey-rmSCrefpEH7FY0x9IWYT_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652411103</pqid></control><display><type>article</type><title>Cord serum dipeptidyl-peptidase 4 activity in gestational diabetes</title><source>MEDLINE</source><source>Wiley Online Library (Online service)</source><creator>Al-Aissa, Zahra ; Rosta, Klára ; Hadarits, Orsolya ; Harreiter, Jürgen ; Zóka, András ; Bancher-Todesca, Dagmar ; Patócs, Attila ; Kiss, Katalin ; Sármán, Beatrix ; Pusztai, Péter ; Sziller, István ; Rigó, János ; Rácz, Károly ; Somogyi, Anikó ; Kautzky-Willer, Alexandra ; Firneisz, Gábor</creator><creatorcontrib>Al-Aissa, Zahra ; Rosta, Klára ; Hadarits, Orsolya ; Harreiter, Jürgen ; Zóka, András ; Bancher-Todesca, Dagmar ; Patócs, Attila ; Kiss, Katalin ; Sármán, Beatrix ; Pusztai, Péter ; Sziller, István ; Rigó, János ; Rácz, Károly ; Somogyi, Anikó ; Kautzky-Willer, Alexandra ; Firneisz, Gábor</creatorcontrib><description>Background
Tissue‐specific dipeptidyl‐peptidase 4 (DPP4) dysregulation has been described in adults with diabetes mellitus. The DPP4 ‐incretin system has not been studied in foetal life. In this study, DPP4 activity and glucagon‐like peptide‐1 (GLP‐1) levels were assessed in cord blood of neonates born to women with gestational diabetes mellitus (GDM) and nondiabetic controls.
Material and methods
This study has been conducted in two Hungarian and one Austrian centres. Patients: A total of 568 pregnant women were enrolled in the study after their OGTT between the 24th and 28th gestational week. Cord blood samplings with DPP4 activity and GLP‐1 level measurements were possible in 270 (DPP4: 159 control, 111 GDM) and 112 (GLP‐1: 72 control, 40 GDM) cases. OGTT (24–28th gestational week) and cord blood sampling at delivery were performed. Cord serum DPP4 activity was determined in a continuous monitoring microplate‐based kinetic assay, and cord plasma GLP‐1 was measured using a fluorescence ELISA method.
Results
Cord serum DPP4 activity was lower in GDM [mean (95% CI): 28·07 U/L (26·32–29·82 U/L)] than in controls [31·61 U/L (29·93–33·29 U/L), MWU P = 0·0015]. Cord plasma active GLP‐1 levels were close to the lower detection limit and were not altered in GDM (control: mean = 3·43 pM, 95% CI: 3·04–3·82 pM, GDM: mean = 3·61 pM, 95% CI: 2·96–4·28 pM – MWU test P = 0·6).
Conclusions
Decreased cord serum DPP4 activity in gestational diabetes mellitus might be the result of an adaptive foetal response or an early dysregulation in the entero‐insular axis with consequences beyond the incretin system. Cord plasma GLP‐1 levels may reflect the missing oral intake with a limited glucose sensing of L cells via the circulation in foetal life.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.12397</identifier><identifier>PMID: 25556541</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Blood Glucose - metabolism ; Case-Control Studies ; Cord blood ; Diabetes, Gestational - diet therapy ; Diabetes, Gestational - drug therapy ; Diabetes, Gestational - enzymology ; Dipeptidyl Peptidase 4 - metabolism ; dipeptidyl-peptidase 4 (DPP4) ; Female ; Fetal Blood - metabolism ; gestational diabetes mellitus (GDM) ; Glucagon-Like Peptide 1 - metabolism ; glucagon-like peptide-1 (GLP-1) ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulins - therapeutic use ; Pregnancy ; Pregnancy Outcome</subject><ispartof>European journal of clinical investigation, 2015-02, Vol.45 (2), p.196-203</ispartof><rights>2014 Stichting European Society for Clinical Investigation Journal Foundation</rights><rights>2014 Stichting European Society for Clinical Investigation Journal Foundation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3637-b7bb5a7c3c31c6f0d91559ffc7f3caea98836267b5a94a1ba8878deebeb8afb73</citedby><cites>FETCH-LOGICAL-c3637-b7bb5a7c3c31c6f0d91559ffc7f3caea98836267b5a94a1ba8878deebeb8afb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feci.12397$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feci.12397$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25556541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Aissa, Zahra</creatorcontrib><creatorcontrib>Rosta, Klára</creatorcontrib><creatorcontrib>Hadarits, Orsolya</creatorcontrib><creatorcontrib>Harreiter, Jürgen</creatorcontrib><creatorcontrib>Zóka, András</creatorcontrib><creatorcontrib>Bancher-Todesca, Dagmar</creatorcontrib><creatorcontrib>Patócs, Attila</creatorcontrib><creatorcontrib>Kiss, Katalin</creatorcontrib><creatorcontrib>Sármán, Beatrix</creatorcontrib><creatorcontrib>Pusztai, Péter</creatorcontrib><creatorcontrib>Sziller, István</creatorcontrib><creatorcontrib>Rigó, János</creatorcontrib><creatorcontrib>Rácz, Károly</creatorcontrib><creatorcontrib>Somogyi, Anikó</creatorcontrib><creatorcontrib>Kautzky-Willer, Alexandra</creatorcontrib><creatorcontrib>Firneisz, Gábor</creatorcontrib><title>Cord serum dipeptidyl-peptidase 4 activity in gestational diabetes</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background
Tissue‐specific dipeptidyl‐peptidase 4 (DPP4) dysregulation has been described in adults with diabetes mellitus. The DPP4 ‐incretin system has not been studied in foetal life. In this study, DPP4 activity and glucagon‐like peptide‐1 (GLP‐1) levels were assessed in cord blood of neonates born to women with gestational diabetes mellitus (GDM) and nondiabetic controls.
Material and methods
This study has been conducted in two Hungarian and one Austrian centres. Patients: A total of 568 pregnant women were enrolled in the study after their OGTT between the 24th and 28th gestational week. Cord blood samplings with DPP4 activity and GLP‐1 level measurements were possible in 270 (DPP4: 159 control, 111 GDM) and 112 (GLP‐1: 72 control, 40 GDM) cases. OGTT (24–28th gestational week) and cord blood sampling at delivery were performed. Cord serum DPP4 activity was determined in a continuous monitoring microplate‐based kinetic assay, and cord plasma GLP‐1 was measured using a fluorescence ELISA method.
Results
Cord serum DPP4 activity was lower in GDM [mean (95% CI): 28·07 U/L (26·32–29·82 U/L)] than in controls [31·61 U/L (29·93–33·29 U/L), MWU P = 0·0015]. Cord plasma active GLP‐1 levels were close to the lower detection limit and were not altered in GDM (control: mean = 3·43 pM, 95% CI: 3·04–3·82 pM, GDM: mean = 3·61 pM, 95% CI: 2·96–4·28 pM – MWU test P = 0·6).
Conclusions
Decreased cord serum DPP4 activity in gestational diabetes mellitus might be the result of an adaptive foetal response or an early dysregulation in the entero‐insular axis with consequences beyond the incretin system. Cord plasma GLP‐1 levels may reflect the missing oral intake with a limited glucose sensing of L cells via the circulation in foetal life.</description><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>Cord blood</subject><subject>Diabetes, Gestational - diet therapy</subject><subject>Diabetes, Gestational - drug therapy</subject><subject>Diabetes, Gestational - enzymology</subject><subject>Dipeptidyl Peptidase 4 - metabolism</subject><subject>dipeptidyl-peptidase 4 (DPP4)</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>gestational diabetes mellitus (GDM)</subject><subject>Glucagon-Like Peptide 1 - metabolism</subject><subject>glucagon-like peptide-1 (GLP-1)</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulins - therapeutic use</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLFOwzAQhi0EoqUw8AIoIwxp7TiOkxGi0laqCkhFjJbtXJAhaUqcAHl7DGm7ccvd8P2_Th9ClwSPiZsJaDMmAU34ERoSGjE_oFFwjIYYk9APEh4M0Jm1bxjjmNDgFA0CxljEQjJEd2lVZ56Fui29zGxh25isK_z-kBa80JO6MZ-m6Tyz8V7BNrIx1UYWDpcKGrDn6CSXhYWL3R6h5_vpOp37y4fZIr1d-ppGlPuKK8Uk11RToqMcZwlhLMlzzXOqJcgkjt3XEXdQEkqiZBzzOANQoGKZK05H6Lrv3dbVR-seEaWxGopCbqBqrSARC0KnA1OH3vSoritra8jFtjalrDtBsPhVJpwy8afMsVe72laVkB3IvSMHTHrgyxTQ_d8kpuliX-n3CWMb-D4kZP0uIk45Ey-rmSCrefpEH7FY0x9IWYT_</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Al-Aissa, Zahra</creator><creator>Rosta, Klára</creator><creator>Hadarits, Orsolya</creator><creator>Harreiter, Jürgen</creator><creator>Zóka, András</creator><creator>Bancher-Todesca, Dagmar</creator><creator>Patócs, Attila</creator><creator>Kiss, Katalin</creator><creator>Sármán, Beatrix</creator><creator>Pusztai, Péter</creator><creator>Sziller, István</creator><creator>Rigó, János</creator><creator>Rácz, Károly</creator><creator>Somogyi, Anikó</creator><creator>Kautzky-Willer, Alexandra</creator><creator>Firneisz, Gábor</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Cord serum dipeptidyl-peptidase 4 activity in gestational diabetes</title><author>Al-Aissa, Zahra ; Rosta, Klára ; Hadarits, Orsolya ; Harreiter, Jürgen ; Zóka, András ; Bancher-Todesca, Dagmar ; Patócs, Attila ; Kiss, Katalin ; Sármán, Beatrix ; Pusztai, Péter ; Sziller, István ; Rigó, János ; Rácz, Károly ; Somogyi, Anikó ; Kautzky-Willer, Alexandra ; Firneisz, Gábor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3637-b7bb5a7c3c31c6f0d91559ffc7f3caea98836267b5a94a1ba8878deebeb8afb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Case-Control Studies</topic><topic>Cord blood</topic><topic>Diabetes, Gestational - diet therapy</topic><topic>Diabetes, Gestational - drug therapy</topic><topic>Diabetes, Gestational - enzymology</topic><topic>Dipeptidyl Peptidase 4 - metabolism</topic><topic>dipeptidyl-peptidase 4 (DPP4)</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>gestational diabetes mellitus (GDM)</topic><topic>Glucagon-Like Peptide 1 - metabolism</topic><topic>glucagon-like peptide-1 (GLP-1)</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulins - therapeutic use</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Aissa, Zahra</creatorcontrib><creatorcontrib>Rosta, Klára</creatorcontrib><creatorcontrib>Hadarits, Orsolya</creatorcontrib><creatorcontrib>Harreiter, Jürgen</creatorcontrib><creatorcontrib>Zóka, András</creatorcontrib><creatorcontrib>Bancher-Todesca, Dagmar</creatorcontrib><creatorcontrib>Patócs, Attila</creatorcontrib><creatorcontrib>Kiss, Katalin</creatorcontrib><creatorcontrib>Sármán, Beatrix</creatorcontrib><creatorcontrib>Pusztai, Péter</creatorcontrib><creatorcontrib>Sziller, István</creatorcontrib><creatorcontrib>Rigó, János</creatorcontrib><creatorcontrib>Rácz, Károly</creatorcontrib><creatorcontrib>Somogyi, Anikó</creatorcontrib><creatorcontrib>Kautzky-Willer, Alexandra</creatorcontrib><creatorcontrib>Firneisz, Gábor</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Aissa, Zahra</au><au>Rosta, Klára</au><au>Hadarits, Orsolya</au><au>Harreiter, Jürgen</au><au>Zóka, András</au><au>Bancher-Todesca, Dagmar</au><au>Patócs, Attila</au><au>Kiss, Katalin</au><au>Sármán, Beatrix</au><au>Pusztai, Péter</au><au>Sziller, István</au><au>Rigó, János</au><au>Rácz, Károly</au><au>Somogyi, Anikó</au><au>Kautzky-Willer, Alexandra</au><au>Firneisz, Gábor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cord serum dipeptidyl-peptidase 4 activity in gestational diabetes</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2015-02</date><risdate>2015</risdate><volume>45</volume><issue>2</issue><spage>196</spage><epage>203</epage><pages>196-203</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
Tissue‐specific dipeptidyl‐peptidase 4 (DPP4) dysregulation has been described in adults with diabetes mellitus. The DPP4 ‐incretin system has not been studied in foetal life. In this study, DPP4 activity and glucagon‐like peptide‐1 (GLP‐1) levels were assessed in cord blood of neonates born to women with gestational diabetes mellitus (GDM) and nondiabetic controls.
Material and methods
This study has been conducted in two Hungarian and one Austrian centres. Patients: A total of 568 pregnant women were enrolled in the study after their OGTT between the 24th and 28th gestational week. Cord blood samplings with DPP4 activity and GLP‐1 level measurements were possible in 270 (DPP4: 159 control, 111 GDM) and 112 (GLP‐1: 72 control, 40 GDM) cases. OGTT (24–28th gestational week) and cord blood sampling at delivery were performed. Cord serum DPP4 activity was determined in a continuous monitoring microplate‐based kinetic assay, and cord plasma GLP‐1 was measured using a fluorescence ELISA method.
Results
Cord serum DPP4 activity was lower in GDM [mean (95% CI): 28·07 U/L (26·32–29·82 U/L)] than in controls [31·61 U/L (29·93–33·29 U/L), MWU P = 0·0015]. Cord plasma active GLP‐1 levels were close to the lower detection limit and were not altered in GDM (control: mean = 3·43 pM, 95% CI: 3·04–3·82 pM, GDM: mean = 3·61 pM, 95% CI: 2·96–4·28 pM – MWU test P = 0·6).
Conclusions
Decreased cord serum DPP4 activity in gestational diabetes mellitus might be the result of an adaptive foetal response or an early dysregulation in the entero‐insular axis with consequences beyond the incretin system. Cord plasma GLP‐1 levels may reflect the missing oral intake with a limited glucose sensing of L cells via the circulation in foetal life.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25556541</pmid><doi>10.1111/eci.12397</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of clinical investigation, 2015-02, Vol.45 (2), p.196-203 |
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| subjects | Adult Blood Glucose - metabolism Case-Control Studies Cord blood Diabetes, Gestational - diet therapy Diabetes, Gestational - drug therapy Diabetes, Gestational - enzymology Dipeptidyl Peptidase 4 - metabolism dipeptidyl-peptidase 4 (DPP4) Female Fetal Blood - metabolism gestational diabetes mellitus (GDM) Glucagon-Like Peptide 1 - metabolism glucagon-like peptide-1 (GLP-1) Humans Hypoglycemic Agents - therapeutic use Insulins - therapeutic use Pregnancy Pregnancy Outcome |
| title | Cord serum dipeptidyl-peptidase 4 activity in gestational diabetes |
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