Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide

Mice given 1% alpha-difluoromethylornithine (DFMO) in the drinking water for 5 weeks developed a hyperactive behavior characterized by uncontrolled running upon stimulation with noise. The running was followed by seizures and sometimes death. These behaviors are characteristic of audiogenic seizures...

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Veröffentlicht in:	Life sciences (1973) 1993, Vol.52 (13), p.1101-1108
Hauptverfasser:	Gerrish, K.E., Fuller, D.J.M., Gerner, E.W., Gensler, H.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Biological and medical sciences Brain - drug effects Brain - metabolism Chlordiazepoxide - therapeutic use Eflornithine - antagonists & inhibitors Female gamma-Aminobutyric Acid - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred CBA Nervous system involvement in other diseases. Miscellaneous Neurology Polyamines - metabolism Seizures - chemically induced Seizures - etiology Seizures - prevention & control
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