Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide
Mice given 1% alpha-difluoromethylornithine (DFMO) in the drinking water for 5 weeks developed a hyperactive behavior characterized by uncontrolled running upon stimulation with noise. The running was followed by seizures and sometimes death. These behaviors are characteristic of audiogenic seizures...
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| Veröffentlicht in: | Life sciences (1973) 1993, Vol.52 (13), p.1101-1108 |
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| container_end_page | 1108 |
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| container_issue | 13 |
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| container_title | Life sciences (1973) |
| container_volume | 52 |
| creator | Gerrish, K.E. Fuller, D.J.M. Gerner, E.W. Gensler, H.L. |
| description | Mice given 1% alpha-difluoromethylornithine (DFMO) in the drinking water for 5 weeks developed a hyperactive behavior characterized by uncontrolled running upon stimulation with noise. The running was followed by seizures and sometimes death. These behaviors are characteristic of audiogenic seizures. Strain differences in susceptibility to DFMO-induced audiogenic seizures were observed. The order of sensitivity to this DFMO effect was: C3HeB/FEJ=C3H/HeN>CBA/J=BALB/c. Chronic DFMO treatment was found to deplete whole brain putrescine and spermidine, but not spermine nor gamma-aminobutyric acid (GABA), in the 2 strains of mice analyzed, C3H/HeN and BALB/c. The audiogenic seizures were eliminated by pretreatment with the benzodiazepine, chlordiazepoxide (Librium) (40 mg/kg, ip) 105 minutes prior to testing for seizures. |
| doi_str_mv | 10.1016/0024-3205(93)90431-2 |
| format | Article |
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The running was followed by seizures and sometimes death. These behaviors are characteristic of audiogenic seizures. Strain differences in susceptibility to DFMO-induced audiogenic seizures were observed. The order of sensitivity to this DFMO effect was: C3HeB/FEJ=C3H/HeN>CBA/J=BALB/c. Chronic DFMO treatment was found to deplete whole brain putrescine and spermidine, but not spermine nor gamma-aminobutyric acid (GABA), in the 2 strains of mice analyzed, C3H/HeN and BALB/c. The audiogenic seizures were eliminated by pretreatment with the benzodiazepine, chlordiazepoxide (Librium) (40 mg/kg, ip) 105 minutes prior to testing for seizures.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(93)90431-2</identifier><identifier>PMID: 8450705</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Acoustic Stimulation ; Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Chlordiazepoxide - therapeutic use ; Eflornithine - antagonists & inhibitors ; Female ; gamma-Aminobutyric Acid - metabolism ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred CBA ; Nervous system involvement in other diseases. 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The running was followed by seizures and sometimes death. These behaviors are characteristic of audiogenic seizures. Strain differences in susceptibility to DFMO-induced audiogenic seizures were observed. The order of sensitivity to this DFMO effect was: C3HeB/FEJ=C3H/HeN>CBA/J=BALB/c. Chronic DFMO treatment was found to deplete whole brain putrescine and spermidine, but not spermine nor gamma-aminobutyric acid (GABA), in the 2 strains of mice analyzed, C3H/HeN and BALB/c. The audiogenic seizures were eliminated by pretreatment with the benzodiazepine, chlordiazepoxide (Librium) (40 mg/kg, ip) 105 minutes prior to testing for seizures.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Chlordiazepoxide - therapeutic use</subject><subject>Eflornithine - antagonists & inhibitors</subject><subject>Female</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred CBA</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Polyamines - metabolism</subject><subject>Seizures - chemically induced</subject><subject>Seizures - etiology</subject><subject>Seizures - prevention & control</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAURS0EKtPCPwApC4TKIvD8FcebSlAoVCrqpnvLfn6hRpl4sCeI9teTYUazZPUW99yrp8PYKw7vOfDuA4BQrRSgz618Z0FJ3oonbMV7Y1voJH_KVkfkOTut9ScAaG3kCTvplQYDesU-XU_3KaRtylOTh-bz1ffbNk1xRoqNn2PKP2hK2FRKj3Oh2oSHBu_HXGLyj7TJf1KkF-zZ4MdKLw_3jN1dfbm7_Nbe3H69vvx406LiZtsq0RtAjgjCaissiD6A1DJCB9EHafkgg5VCB8TOmt4HimBQKo_BBCPP2Nv97KbkXzPVrVunijSOfqI8V8c7LRTnsIBqD2LJtRYa3KaktS8PjoPbmXM7LW6nxVnp_plzYqm9PuzPYU3xWDqoWvI3h9xX9ONQ_ISpHjFluFKmX7CLPUaLit-JiquYaFp8pkK4dTGn___xF72NiIM</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Gerrish, K.E.</creator><creator>Fuller, D.J.M.</creator><creator>Gerner, E.W.</creator><creator>Gensler, H.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>1993</creationdate><title>Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide</title><author>Gerrish, K.E. ; Fuller, D.J.M. ; Gerner, E.W. ; Gensler, H.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-42870c1cc0295929028b0353d060dab391f3b9325bcc6978abed07c34acb7b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Chlordiazepoxide - therapeutic use</topic><topic>Eflornithine - antagonists & inhibitors</topic><topic>Female</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred CBA</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Polyamines - metabolism</topic><topic>Seizures - chemically induced</topic><topic>Seizures - etiology</topic><topic>Seizures - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerrish, K.E.</creatorcontrib><creatorcontrib>Fuller, D.J.M.</creatorcontrib><creatorcontrib>Gerner, E.W.</creatorcontrib><creatorcontrib>Gensler, H.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerrish, K.E.</au><au>Fuller, D.J.M.</au><au>Gerner, E.W.</au><au>Gensler, H.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1993</date><risdate>1993</risdate><volume>52</volume><issue>13</issue><spage>1101</spage><epage>1108</epage><pages>1101-1108</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Mice given 1% alpha-difluoromethylornithine (DFMO) in the drinking water for 5 weeks developed a hyperactive behavior characterized by uncontrolled running upon stimulation with noise. The running was followed by seizures and sometimes death. These behaviors are characteristic of audiogenic seizures. Strain differences in susceptibility to DFMO-induced audiogenic seizures were observed. The order of sensitivity to this DFMO effect was: C3HeB/FEJ=C3H/HeN>CBA/J=BALB/c. Chronic DFMO treatment was found to deplete whole brain putrescine and spermidine, but not spermine nor gamma-aminobutyric acid (GABA), in the 2 strains of mice analyzed, C3H/HeN and BALB/c. The audiogenic seizures were eliminated by pretreatment with the benzodiazepine, chlordiazepoxide (Librium) (40 mg/kg, ip) 105 minutes prior to testing for seizures.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>8450705</pmid><doi>10.1016/0024-3205(93)90431-2</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acoustic Stimulation Animals Biological and medical sciences Brain - drug effects Brain - metabolism Chlordiazepoxide - therapeutic use Eflornithine - antagonists & inhibitors Female gamma-Aminobutyric Acid - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred CBA Nervous system involvement in other diseases. Miscellaneous Neurology Polyamines - metabolism Seizures - chemically induced Seizures - etiology Seizures - prevention & control |
| title | Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide |
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