ANGPTL4 regulates the metastatic potential of oral squamous cell carcinoma
Lymph node metastasis is a major factor for poor prognosis in oral squamous cell carcinoma (OSCC). However, the molecular mechanisms of lymph node metastasis are unclear. We determined that angiopoietin‐like protein 4 (ANGPTL4) mRNA and protein expression were increased in OSCC cells established fro...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2015-02, Vol.44 (2), p.126-133 |
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| container_title | Journal of oral pathology & medicine |
| container_volume | 44 |
| creator | Tanaka, Junichi Irié, Tarou Yamamoto, Gou Yasuhara, Rika Isobe, Tomohide Hokazono, Chie Tachikawa, Tetsuhiko Kohno, Yohko Mishima, Kenji |
| description | Lymph node metastasis is a major factor for poor prognosis in oral squamous cell carcinoma (OSCC). However, the molecular mechanisms of lymph node metastasis are unclear. We determined that angiopoietin‐like protein 4 (ANGPTL4) mRNA and protein expression were increased in OSCC cells established from the primary site in metastatic cases. In addition, ANGPTL4 expression in biopsy specimens was correlated with the presence of lymph node metastasis. Therefore, our initial findings suggest that OSCC cells expressing ANGPTL4 may possess metastatic ability. Furthermore, cell culture supernatants from OSCC cells that metastasized to the lymph node contain ANGPTL4 and promote invasive ability. These findings suggest that secreted ANGPTL4 may affect the invasive ability of OSCC. Moreover, the rates of positive ANGPTL4 expression at the primary site were significantly higher in the lymph node metastasis group. These results demonstrate that ANGPTL4 contributes to OSCC metastasis by stimulating cell invasion. Therefore, ANGPTL4 is a potential therapeutic target for preventing cancer metastasis. |
| doi_str_mv | 10.1111/jop.12212 |
| format | Article |
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However, the molecular mechanisms of lymph node metastasis are unclear. We determined that angiopoietin‐like protein 4 (ANGPTL4) mRNA and protein expression were increased in OSCC cells established from the primary site in metastatic cases. In addition, ANGPTL4 expression in biopsy specimens was correlated with the presence of lymph node metastasis. Therefore, our initial findings suggest that OSCC cells expressing ANGPTL4 may possess metastatic ability. Furthermore, cell culture supernatants from OSCC cells that metastasized to the lymph node contain ANGPTL4 and promote invasive ability. These findings suggest that secreted ANGPTL4 may affect the invasive ability of OSCC. Moreover, the rates of positive ANGPTL4 expression at the primary site were significantly higher in the lymph node metastasis group. These results demonstrate that ANGPTL4 contributes to OSCC metastasis by stimulating cell invasion. Therefore, ANGPTL4 is a potential therapeutic target for preventing cancer metastasis.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.12212</identifier><identifier>PMID: 25060575</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Angiopoietin-like 4 Protein ; angiopoietin-like protein 4 ; Angiopoietins - genetics ; Angiopoietins - physiology ; Biomarkers, Tumor - analysis ; Biopsy ; cancer therapy ; Carcinoma, Squamous Cell - chemistry ; Carcinoma, Squamous Cell - secondary ; Cell Culture Techniques ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Culture Media, Conditioned ; Dentistry ; Female ; Gene Knockdown Techniques ; Gene Silencing ; Humans ; Immunohistochemistry ; invasion ; lymph node metastasis ; Lymphatic Metastasis - pathology ; Male ; Mouth Neoplasms - chemistry ; Mouth Neoplasms - pathology ; Neoplasm Grading ; oral squamous cell carcinoma ; RNA, Small Interfering - genetics</subject><ispartof>Journal of oral pathology & medicine, 2015-02, Vol.44 (2), p.126-133</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.12212$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.12212$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25060575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Junichi</creatorcontrib><creatorcontrib>Irié, Tarou</creatorcontrib><creatorcontrib>Yamamoto, Gou</creatorcontrib><creatorcontrib>Yasuhara, Rika</creatorcontrib><creatorcontrib>Isobe, Tomohide</creatorcontrib><creatorcontrib>Hokazono, Chie</creatorcontrib><creatorcontrib>Tachikawa, Tetsuhiko</creatorcontrib><creatorcontrib>Kohno, Yohko</creatorcontrib><creatorcontrib>Mishima, Kenji</creatorcontrib><title>ANGPTL4 regulates the metastatic potential of oral squamous cell carcinoma</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Lymph node metastasis is a major factor for poor prognosis in oral squamous cell carcinoma (OSCC). However, the molecular mechanisms of lymph node metastasis are unclear. We determined that angiopoietin‐like protein 4 (ANGPTL4) mRNA and protein expression were increased in OSCC cells established from the primary site in metastatic cases. In addition, ANGPTL4 expression in biopsy specimens was correlated with the presence of lymph node metastasis. Therefore, our initial findings suggest that OSCC cells expressing ANGPTL4 may possess metastatic ability. Furthermore, cell culture supernatants from OSCC cells that metastasized to the lymph node contain ANGPTL4 and promote invasive ability. These findings suggest that secreted ANGPTL4 may affect the invasive ability of OSCC. Moreover, the rates of positive ANGPTL4 expression at the primary site were significantly higher in the lymph node metastasis group. These results demonstrate that ANGPTL4 contributes to OSCC metastasis by stimulating cell invasion. Therefore, ANGPTL4 is a potential therapeutic target for preventing cancer metastasis.</description><subject>Angiopoietin-like 4 Protein</subject><subject>angiopoietin-like protein 4</subject><subject>Angiopoietins - genetics</subject><subject>Angiopoietins - physiology</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy</subject><subject>cancer therapy</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Cell Culture Techniques</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Culture Media, Conditioned</subject><subject>Dentistry</subject><subject>Female</subject><subject>Gene Knockdown Techniques</subject><subject>Gene Silencing</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>invasion</subject><subject>lymph node metastasis</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Mouth Neoplasms - chemistry</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Grading</subject><subject>oral squamous cell carcinoma</subject><subject>RNA, Small Interfering - genetics</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UEtPwkAQ3hiNIHrwD5gevRT2vXAkRKuEAAcMx82ynWqxpdDdRvn3Lg-ZOcxM5vvm8SH0SHCXBOutq22XUEroFWoTiXGMFeHXqI0HmMdUENpCd86tMSaKcXKLWlRgiYUSbTQeTpP5YsKjGj6bwnhwkf-CqARvnDc-t9G28rDxuSmiKouqOkS3a0xZNS6yUBSRNbXNN1Vp7tFNZgoHD-fYQR-vL4vRWzyZJe-j4STOORU0lkr2LctSZZlMIVTBLecWgDHC5AAsBsgwwaIvWLpSXBoSOgCEqwFWhnXQ82nutq52DTivy9wdTjEbCFdpIgXl4T-pAvTpDG1WJaR6W-elqff6__8A6J0AP3kB-0ufYH0QVgdh9VFYPZ7Nj0lgxCdG7jz8Xhim_tZhoRJ6OU00XSrJ6TjRiv0Boml3yA</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Tanaka, Junichi</creator><creator>Irié, Tarou</creator><creator>Yamamoto, Gou</creator><creator>Yasuhara, Rika</creator><creator>Isobe, Tomohide</creator><creator>Hokazono, Chie</creator><creator>Tachikawa, Tetsuhiko</creator><creator>Kohno, Yohko</creator><creator>Mishima, Kenji</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>ANGPTL4 regulates the metastatic potential of oral squamous cell carcinoma</title><author>Tanaka, Junichi ; Irié, Tarou ; Yamamoto, Gou ; Yasuhara, Rika ; Isobe, Tomohide ; Hokazono, Chie ; Tachikawa, Tetsuhiko ; Kohno, Yohko ; Mishima, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4252-6768c3fd7c36de676767c44cee331369ec0eef0105853db746a1331ee147907a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Angiopoietin-like 4 Protein</topic><topic>angiopoietin-like protein 4</topic><topic>Angiopoietins - genetics</topic><topic>Angiopoietins - physiology</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy</topic><topic>cancer therapy</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Cell Culture Techniques</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Culture Media, Conditioned</topic><topic>Dentistry</topic><topic>Female</topic><topic>Gene Knockdown Techniques</topic><topic>Gene Silencing</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>invasion</topic><topic>lymph node metastasis</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Mouth Neoplasms - chemistry</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Grading</topic><topic>oral squamous cell carcinoma</topic><topic>RNA, Small Interfering - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Junichi</creatorcontrib><creatorcontrib>Irié, Tarou</creatorcontrib><creatorcontrib>Yamamoto, Gou</creatorcontrib><creatorcontrib>Yasuhara, Rika</creatorcontrib><creatorcontrib>Isobe, Tomohide</creatorcontrib><creatorcontrib>Hokazono, Chie</creatorcontrib><creatorcontrib>Tachikawa, Tetsuhiko</creatorcontrib><creatorcontrib>Kohno, Yohko</creatorcontrib><creatorcontrib>Mishima, Kenji</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Junichi</au><au>Irié, Tarou</au><au>Yamamoto, Gou</au><au>Yasuhara, Rika</au><au>Isobe, Tomohide</au><au>Hokazono, Chie</au><au>Tachikawa, Tetsuhiko</au><au>Kohno, Yohko</au><au>Mishima, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANGPTL4 regulates the metastatic potential of oral squamous cell carcinoma</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2015-02</date><risdate>2015</risdate><volume>44</volume><issue>2</issue><spage>126</spage><epage>133</epage><pages>126-133</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Lymph node metastasis is a major factor for poor prognosis in oral squamous cell carcinoma (OSCC). However, the molecular mechanisms of lymph node metastasis are unclear. We determined that angiopoietin‐like protein 4 (ANGPTL4) mRNA and protein expression were increased in OSCC cells established from the primary site in metastatic cases. In addition, ANGPTL4 expression in biopsy specimens was correlated with the presence of lymph node metastasis. Therefore, our initial findings suggest that OSCC cells expressing ANGPTL4 may possess metastatic ability. Furthermore, cell culture supernatants from OSCC cells that metastasized to the lymph node contain ANGPTL4 and promote invasive ability. These findings suggest that secreted ANGPTL4 may affect the invasive ability of OSCC. Moreover, the rates of positive ANGPTL4 expression at the primary site were significantly higher in the lymph node metastasis group. These results demonstrate that ANGPTL4 contributes to OSCC metastasis by stimulating cell invasion. Therefore, ANGPTL4 is a potential therapeutic target for preventing cancer metastasis.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>25060575</pmid><doi>10.1111/jop.12212</doi><tpages>8</tpages></addata></record> |
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| subjects | Angiopoietin-like 4 Protein angiopoietin-like protein 4 Angiopoietins - genetics Angiopoietins - physiology Biomarkers, Tumor - analysis Biopsy cancer therapy Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - secondary Cell Culture Techniques Cell Line, Tumor Cell Movement Cell Proliferation Culture Media, Conditioned Dentistry Female Gene Knockdown Techniques Gene Silencing Humans Immunohistochemistry invasion lymph node metastasis Lymphatic Metastasis - pathology Male Mouth Neoplasms - chemistry Mouth Neoplasms - pathology Neoplasm Grading oral squamous cell carcinoma RNA, Small Interfering - genetics |
| title | ANGPTL4 regulates the metastatic potential of oral squamous cell carcinoma |
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