Enhanced desensitization followed by unusual resensitization in GABAA receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice

Phospholipase C-related catalytically inactive proteins (PRIP-1/2) are previously reported to be involved in the membrane trafficking of GABA A receptor (GABA A R) and the regulation of intracellular Ca 2+ stores. GABA A R-mediated currents can be regulated by the intracellular Ca 2+ . However, in P...

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Veröffentlicht in:	Pflügers Archiv 2015-02, Vol.467 (2), p.267-284
Hauptverfasser:	Toyoda, Hiroki, Saito, Mitsuru, Sato, Hajime, Tanaka, Takuma, Ogawa, Takeo, Yatani, Hirofumi, Kawano, Tsutomu, Kanematsu, Takashi, Hirata, Masato, Kang, Youngnam
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biomedical and Life Sciences Biomedicine Calcium Signaling Catalytic Domain - genetics Cell Biology GABA-A Receptor Antagonists - pharmacology Human Physiology Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Ion Channels Mice Mice, Inbred C57BL Molecular Medicine Neurosciences Pyramidal Cells - drug effects Pyramidal Cells - metabolism Pyramidal Cells - physiology Receptors Receptors and Transporters Receptors, GABA-A - metabolism
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