Does omega-3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta-analysis on randomized controlled clinical trials
Summary Background Omega‐3 fatty acids have attracted researchers for their effect on circulatory hormone‐like peptides affecting weight control. Objective Our objective was to conduct a systematic review and meta‐analysis on randomized controlled trials (RCTs) assessed the effects of omega‐3 supple...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2015-02, Vol.82 (2), p.221-228 |
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| creator | Hariri, Mitra Ghiasvand, Reza Shiranian, Afshin Askari, Gholamreza Iraj, Bijan Salehi-Abargouei, Amin |
| description | Summary
Background
Omega‐3 fatty acids have attracted researchers for their effect on circulatory hormone‐like peptides affecting weight control.
Objective
Our objective was to conduct a systematic review and meta‐analysis on randomized controlled trials (RCTs) assessed the effects of omega‐3 supplementation on serum leptin concentration and to find the possible sources of heterogeneity in their results.
Methods
We searched PubMed/Medline, Google Scholar, Ovid, SCOPUS and ISI web of science up to April 2014. RCTs conducted among human adults, examined the effect of omega‐3 fatty acid supplements on serum leptin concentrations as an outcome variable were included. The mean difference and standard deviation (SD) of changes in serum leptin levels were used as effect size for the meta‐analysis. Summary mean estimates with their corresponding SDs were derived using random effects model.
Results
Totally 14 RCTs were eligible to be included in the systematic review, and the meta‐analysis was performed on 13 articles. Our analysis showed that omega‐3 supplementation significantly reduces leptin levels (mean difference (MD) = −1·71 ng/ml 95% confidence interval (CI): −3·17 to −0·24, P = 0·022). Subgroup analysis based on BMI status showed that the omega‐3 supplementation reduces leptin when used for nonobese subjects (MD = −3·60 ng/ml; 95% CI −6·23 to −0·90; P = 0·011); however, this was not true for obese participants (MD = −0·86 ng/ml; 95% CI: −2·63 to −0·90; P = 0·296). Subgroup analysis based on omega‐3 source also showed that omega‐3 from marine sources may significantly reduce leptin levels (MD = −1·73 ng/ml; 95% CI −3·25 to −0·2; P = 0·026), but plant sources do not significantly affect serum leptin levels (MD = −1·48 ng/ml; 95% CI −6·78 to 3·23; P = 0·585). Our results were highly sensitive to one study.
Conclusions
Omega‐3 supplementation might moderately decrease circulatory leptin levels only among nonobese adults. RCTs with longer follow‐up period, using higher doses for obese adults and exploring the effect in different genders, are needed to replicate our results. |
| doi_str_mv | 10.1111/cen.12508 |
| format | Article |
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Background
Omega‐3 fatty acids have attracted researchers for their effect on circulatory hormone‐like peptides affecting weight control.
Objective
Our objective was to conduct a systematic review and meta‐analysis on randomized controlled trials (RCTs) assessed the effects of omega‐3 supplementation on serum leptin concentration and to find the possible sources of heterogeneity in their results.
Methods
We searched PubMed/Medline, Google Scholar, Ovid, SCOPUS and ISI web of science up to April 2014. RCTs conducted among human adults, examined the effect of omega‐3 fatty acid supplements on serum leptin concentrations as an outcome variable were included. The mean difference and standard deviation (SD) of changes in serum leptin levels were used as effect size for the meta‐analysis. Summary mean estimates with their corresponding SDs were derived using random effects model.
Results
Totally 14 RCTs were eligible to be included in the systematic review, and the meta‐analysis was performed on 13 articles. Our analysis showed that omega‐3 supplementation significantly reduces leptin levels (mean difference (MD) = −1·71 ng/ml 95% confidence interval (CI): −3·17 to −0·24, P = 0·022). Subgroup analysis based on BMI status showed that the omega‐3 supplementation reduces leptin when used for nonobese subjects (MD = −3·60 ng/ml; 95% CI −6·23 to −0·90; P = 0·011); however, this was not true for obese participants (MD = −0·86 ng/ml; 95% CI: −2·63 to −0·90; P = 0·296). Subgroup analysis based on omega‐3 source also showed that omega‐3 from marine sources may significantly reduce leptin levels (MD = −1·73 ng/ml; 95% CI −3·25 to −0·2; P = 0·026), but plant sources do not significantly affect serum leptin levels (MD = −1·48 ng/ml; 95% CI −6·78 to 3·23; P = 0·585). Our results were highly sensitive to one study.
Conclusions
Omega‐3 supplementation might moderately decrease circulatory leptin levels only among nonobese adults. RCTs with longer follow‐up period, using higher doses for obese adults and exploring the effect in different genders, are needed to replicate our results.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12508</identifier><identifier>PMID: 24862919</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Body Weight - physiology ; Dietary Supplements ; Fatty Acids, Omega-3 - pharmacology ; Female ; Humans ; Leptin - blood ; Male ; Middle Aged ; Randomized Controlled Trials as Topic - statistics & numerical data</subject><ispartof>Clinical endocrinology (Oxford), 2015-02, Vol.82 (2), p.221-228</ispartof><rights>2014 John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4618-96e06bcbcf6410449f03a7f9df4b0a439b0958b491844be35237bd07a08cb02d3</citedby><cites>FETCH-LOGICAL-c4618-96e06bcbcf6410449f03a7f9df4b0a439b0958b491844be35237bd07a08cb02d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12508$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12508$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24862919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hariri, Mitra</creatorcontrib><creatorcontrib>Ghiasvand, Reza</creatorcontrib><creatorcontrib>Shiranian, Afshin</creatorcontrib><creatorcontrib>Askari, Gholamreza</creatorcontrib><creatorcontrib>Iraj, Bijan</creatorcontrib><creatorcontrib>Salehi-Abargouei, Amin</creatorcontrib><title>Does omega-3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta-analysis on randomized controlled clinical trials</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Background
Omega‐3 fatty acids have attracted researchers for their effect on circulatory hormone‐like peptides affecting weight control.
Objective
Our objective was to conduct a systematic review and meta‐analysis on randomized controlled trials (RCTs) assessed the effects of omega‐3 supplementation on serum leptin concentration and to find the possible sources of heterogeneity in their results.
Methods
We searched PubMed/Medline, Google Scholar, Ovid, SCOPUS and ISI web of science up to April 2014. RCTs conducted among human adults, examined the effect of omega‐3 fatty acid supplements on serum leptin concentrations as an outcome variable were included. The mean difference and standard deviation (SD) of changes in serum leptin levels were used as effect size for the meta‐analysis. Summary mean estimates with their corresponding SDs were derived using random effects model.
Results
Totally 14 RCTs were eligible to be included in the systematic review, and the meta‐analysis was performed on 13 articles. Our analysis showed that omega‐3 supplementation significantly reduces leptin levels (mean difference (MD) = −1·71 ng/ml 95% confidence interval (CI): −3·17 to −0·24, P = 0·022). Subgroup analysis based on BMI status showed that the omega‐3 supplementation reduces leptin when used for nonobese subjects (MD = −3·60 ng/ml; 95% CI −6·23 to −0·90; P = 0·011); however, this was not true for obese participants (MD = −0·86 ng/ml; 95% CI: −2·63 to −0·90; P = 0·296). Subgroup analysis based on omega‐3 source also showed that omega‐3 from marine sources may significantly reduce leptin levels (MD = −1·73 ng/ml; 95% CI −3·25 to −0·2; P = 0·026), but plant sources do not significantly affect serum leptin levels (MD = −1·48 ng/ml; 95% CI −6·78 to 3·23; P = 0·585). Our results were highly sensitive to one study.
Conclusions
Omega‐3 supplementation might moderately decrease circulatory leptin levels only among nonobese adults. RCTs with longer follow‐up period, using higher doses for obese adults and exploring the effect in different genders, are needed to replicate our results.</description><subject>Adult</subject><subject>Aged</subject><subject>Body Weight - physiology</subject><subject>Dietary Supplements</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Randomized Controlled Trials as Topic - statistics & numerical data</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAURS0EotPCgh9AltjAIu1L7DjxClVDKaCqLCiwtBznpXJx4sF22oY_4W_xMG0XSHhzredz75N1CXlRwmGZz5HB6bCsamgfkVXJRF1UlagfkxUwgAKE4HtkP8YrAKhbaJ6SvYq3opKlXJHf7zxG6ke81AWjg05podrYPtI4bzYOR5ySTtZPVA8DmkSNDWZ2eTRdUoebrFmu0cW39JjGJSYc86OhAa8t3lA99XTEpAs9abdEm3dNNOSpH-0v7KnxUwreue3V2cka7WgKVrv4jDwZsuDzOz0gX9-fXKw_FGefTz-uj88Kw0XZFlIgiM50ZhC8BM7lAEw3g-wH3oHmTHYg67bjsmw575DVFWu6HhoNremg6tkBeb3L3QT_c8aY1GijQef0hH6OqhTZImXVQkZf_YNe-Tnkj20p3rQgOOeZerOjTPAxBhzUJthRh0WVoLZ9qdyX-ttXZl_eJc7diP0DeV9QBo52wI11uPw_Sa1Pzu8ji53D5i5uHxw6_FCiYU2tvp-fKiY_sS_rb1JdsD8fDLAw</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Hariri, Mitra</creator><creator>Ghiasvand, Reza</creator><creator>Shiranian, Afshin</creator><creator>Askari, Gholamreza</creator><creator>Iraj, Bijan</creator><creator>Salehi-Abargouei, Amin</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Does omega-3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta-analysis on randomized controlled clinical trials</title><author>Hariri, Mitra ; Ghiasvand, Reza ; Shiranian, Afshin ; Askari, Gholamreza ; Iraj, Bijan ; Salehi-Abargouei, Amin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4618-96e06bcbcf6410449f03a7f9df4b0a439b0958b491844be35237bd07a08cb02d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Body Weight - physiology</topic><topic>Dietary Supplements</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Randomized Controlled Trials as Topic - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hariri, Mitra</creatorcontrib><creatorcontrib>Ghiasvand, Reza</creatorcontrib><creatorcontrib>Shiranian, Afshin</creatorcontrib><creatorcontrib>Askari, Gholamreza</creatorcontrib><creatorcontrib>Iraj, Bijan</creatorcontrib><creatorcontrib>Salehi-Abargouei, Amin</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hariri, Mitra</au><au>Ghiasvand, Reza</au><au>Shiranian, Afshin</au><au>Askari, Gholamreza</au><au>Iraj, Bijan</au><au>Salehi-Abargouei, Amin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does omega-3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta-analysis on randomized controlled clinical trials</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2015-02</date><risdate>2015</risdate><volume>82</volume><issue>2</issue><spage>221</spage><epage>228</epage><pages>221-228</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary
Background
Omega‐3 fatty acids have attracted researchers for their effect on circulatory hormone‐like peptides affecting weight control.
Objective
Our objective was to conduct a systematic review and meta‐analysis on randomized controlled trials (RCTs) assessed the effects of omega‐3 supplementation on serum leptin concentration and to find the possible sources of heterogeneity in their results.
Methods
We searched PubMed/Medline, Google Scholar, Ovid, SCOPUS and ISI web of science up to April 2014. RCTs conducted among human adults, examined the effect of omega‐3 fatty acid supplements on serum leptin concentrations as an outcome variable were included. The mean difference and standard deviation (SD) of changes in serum leptin levels were used as effect size for the meta‐analysis. Summary mean estimates with their corresponding SDs were derived using random effects model.
Results
Totally 14 RCTs were eligible to be included in the systematic review, and the meta‐analysis was performed on 13 articles. Our analysis showed that omega‐3 supplementation significantly reduces leptin levels (mean difference (MD) = −1·71 ng/ml 95% confidence interval (CI): −3·17 to −0·24, P = 0·022). Subgroup analysis based on BMI status showed that the omega‐3 supplementation reduces leptin when used for nonobese subjects (MD = −3·60 ng/ml; 95% CI −6·23 to −0·90; P = 0·011); however, this was not true for obese participants (MD = −0·86 ng/ml; 95% CI: −2·63 to −0·90; P = 0·296). Subgroup analysis based on omega‐3 source also showed that omega‐3 from marine sources may significantly reduce leptin levels (MD = −1·73 ng/ml; 95% CI −3·25 to −0·2; P = 0·026), but plant sources do not significantly affect serum leptin levels (MD = −1·48 ng/ml; 95% CI −6·78 to 3·23; P = 0·585). Our results were highly sensitive to one study.
Conclusions
Omega‐3 supplementation might moderately decrease circulatory leptin levels only among nonobese adults. RCTs with longer follow‐up period, using higher doses for obese adults and exploring the effect in different genders, are needed to replicate our results.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24862919</pmid><doi>10.1111/cen.12508</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Body Weight - physiology Dietary Supplements Fatty Acids, Omega-3 - pharmacology Female Humans Leptin - blood Male Middle Aged Randomized Controlled Trials as Topic - statistics & numerical data |
| title | Does omega-3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta-analysis on randomized controlled clinical trials |
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