PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: Perspectives in the diagnosis of pancreatic cancer
Abstract Background and aims Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse...
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| Veröffentlicht in: | Digestive and liver disease 2015-02, Vol.47 (2), p.138-143 |
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| creator | Marzioni, Marco Germani, Ugo Agostinelli, Laura Bedogni, Giorgio Saccomanno, Stefania Marini, Francesco Bellentani, Stefano Barbera, Carmelo De Minicis, Samuele Rychlicki, Chiara Santinelli, Alfredo Ferretti, Maurizio Di Maira, Pier Vittorio Baroni, Gianluca Svegliati Benedetti, Antonio Caletti, Giancarlo Lorenzini, Ivano Fusaroli, Pietro |
| description | Abstract Background and aims Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to verify whether the assessment of PDX-1 in endoscopic ultrasound-guided fine needle aspiration samples may be helpful for the diagnosis of pancreatic cancer. Methods mRNA of 54 pancreatic cancer and 25 cystic lesions was extracted. PDX-1 expression was assessed by Real-Time PCR. Results In all but two patients with pancreatic cancer, PDX-1 was expressed and was found positive in 7 patients with pancreatic cancer in which cytology was negative. The positivity was associated with a probability of 0.98 (95% CI 0.90–1.00) of having cancer and the negativity with one of 0.08 (95% CI 0.01–0.27). The probability of cancer rose to 1.00 (95% CI 0.97–1.00) for patients positive to both PDX-1 and cytology and fell to 0.0 (95% CI 0.00–0.15) in patients negative for both. Conclusions PDX-1mRNA is detectable in samples of pancreatic cancer. Its quantification may be helpful to improve the diagnosis of pancreatic cancer. |
| doi_str_mv | 10.1016/j.dld.2014.10.010 |
| format | Article |
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Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to verify whether the assessment of PDX-1 in endoscopic ultrasound-guided fine needle aspiration samples may be helpful for the diagnosis of pancreatic cancer. Methods mRNA of 54 pancreatic cancer and 25 cystic lesions was extracted. PDX-1 expression was assessed by Real-Time PCR. Results In all but two patients with pancreatic cancer, PDX-1 was expressed and was found positive in 7 patients with pancreatic cancer in which cytology was negative. The positivity was associated with a probability of 0.98 (95% CI 0.90–1.00) of having cancer and the negativity with one of 0.08 (95% CI 0.01–0.27). The probability of cancer rose to 1.00 (95% CI 0.97–1.00) for patients positive to both PDX-1 and cytology and fell to 0.0 (95% CI 0.00–0.15) in patients negative for both. Conclusions PDX-1mRNA is detectable in samples of pancreatic cancer. Its quantification may be helpful to improve the diagnosis of pancreatic cancer.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2014.10.010</identifier><identifier>PMID: 25454709</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; Carcinoma, Pancreatic Ductal - diagnosis ; Carcinoma, Pancreatic Ductal - genetics ; Case-Control Studies ; Cystadenocarcinoma, Mucinous - diagnosis ; Cystadenocarcinoma, Mucinous - genetics ; Cystadenocarcinoma, Serous - diagnosis ; Cystadenocarcinoma, Serous - genetics ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; EUS ; Female ; FNA ; Gastroenterology and Hepatology ; Homeodomain Proteins - genetics ; Humans ; Male ; Middle Aged ; Pancreatic cancer ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - genetics ; Pancreatic Pseudocyst - diagnosis ; Pancreatitis, Chronic - diagnosis ; PDX-1 ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Sensitivity ; Specificity ; Trans-Activators - genetics</subject><ispartof>Digestive and liver disease, 2015-02, Vol.47 (2), p.138-143</ispartof><rights>Editrice Gastroenterologica Italiana S.r.l.</rights><rights>2014 Editrice Gastroenterologica Italiana S.r.l.</rights><rights>Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-b46cc994d655d300483b45003f3666b3732ebdb5011a0943922a1cf8f063cf83</citedby><cites>FETCH-LOGICAL-c408t-b46cc994d655d300483b45003f3666b3732ebdb5011a0943922a1cf8f063cf83</cites><orcidid>0000-0003-2836-8870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2014.10.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25454709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marzioni, Marco</creatorcontrib><creatorcontrib>Germani, Ugo</creatorcontrib><creatorcontrib>Agostinelli, Laura</creatorcontrib><creatorcontrib>Bedogni, Giorgio</creatorcontrib><creatorcontrib>Saccomanno, Stefania</creatorcontrib><creatorcontrib>Marini, Francesco</creatorcontrib><creatorcontrib>Bellentani, Stefano</creatorcontrib><creatorcontrib>Barbera, Carmelo</creatorcontrib><creatorcontrib>De Minicis, Samuele</creatorcontrib><creatorcontrib>Rychlicki, Chiara</creatorcontrib><creatorcontrib>Santinelli, Alfredo</creatorcontrib><creatorcontrib>Ferretti, Maurizio</creatorcontrib><creatorcontrib>Di Maira, Pier Vittorio</creatorcontrib><creatorcontrib>Baroni, Gianluca Svegliati</creatorcontrib><creatorcontrib>Benedetti, Antonio</creatorcontrib><creatorcontrib>Caletti, Giancarlo</creatorcontrib><creatorcontrib>Lorenzini, Ivano</creatorcontrib><creatorcontrib>Fusaroli, Pietro</creatorcontrib><title>PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: Perspectives in the diagnosis of pancreatic cancer</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Abstract Background and aims Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to verify whether the assessment of PDX-1 in endoscopic ultrasound-guided fine needle aspiration samples may be helpful for the diagnosis of pancreatic cancer. Methods mRNA of 54 pancreatic cancer and 25 cystic lesions was extracted. PDX-1 expression was assessed by Real-Time PCR. Results In all but two patients with pancreatic cancer, PDX-1 was expressed and was found positive in 7 patients with pancreatic cancer in which cytology was negative. The positivity was associated with a probability of 0.98 (95% CI 0.90–1.00) of having cancer and the negativity with one of 0.08 (95% CI 0.01–0.27). The probability of cancer rose to 1.00 (95% CI 0.97–1.00) for patients positive to both PDX-1 and cytology and fell to 0.0 (95% CI 0.00–0.15) in patients negative for both. Conclusions PDX-1mRNA is detectable in samples of pancreatic cancer. Its quantification may be helpful to improve the diagnosis of pancreatic cancer.</description><subject>Aged</subject><subject>Carcinoma, Pancreatic Ductal - diagnosis</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Case-Control Studies</subject><subject>Cystadenocarcinoma, Mucinous - diagnosis</subject><subject>Cystadenocarcinoma, Mucinous - genetics</subject><subject>Cystadenocarcinoma, Serous - diagnosis</subject><subject>Cystadenocarcinoma, Serous - genetics</subject><subject>Endoscopic Ultrasound-Guided Fine Needle Aspiration</subject><subject>EUS</subject><subject>Female</subject><subject>FNA</subject><subject>Gastroenterology and Hepatology</subject><subject>Homeodomain Proteins - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Pseudocyst - diagnosis</subject><subject>Pancreatitis, Chronic - diagnosis</subject><subject>PDX-1</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Sensitivity</subject><subject>Specificity</subject><subject>Trans-Activators - genetics</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAQhSMEoqXwA9ggL9nkMo4fNwEJqSpPqYIKumBnOfak-JJrp56kolt-OY5uYcGC1Tx0zpHmm6p6ymHDgesXu40f_aYBLsu8AQ73qmPebttaKN3cL73qoG61ao-qR0Q7gIZrBQ-ro0ZJJbfQHVe_Lt58qznbf_l0yvDnlJEopMhCZBh9Ipem4NgyztlSWqKvr5bg0bMhRGQR0Y_I3O2cLE0h2xlfsgvMNKGbww3SGjN_R-aDvYqJArE0sMlGl9HOJdeVFvPj6sFgR8Ind_Wkunz39vLsQ33--f3Hs9Pz2klo57qX2rmuk14r5QWAbEUvFYAYhNa6F1vRYO97BZxb6KTomsZyN7QDaFGKOKmeH2KnnK4XpNnsAzkcRxsxLWQKmkZ0hZ4qUn6QupyIMg5mymFv863hYFbyZmcKebOSX1eFfPE8u4tf-j36v44_qIvg1UGA5cabgNmQC1gA-JALL-NT-G_863_cbgwxODv-wFukXVpyLPAMN9QYMF_X16-f5xJgq5QSvwFeZ6lL</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Marzioni, Marco</creator><creator>Germani, Ugo</creator><creator>Agostinelli, Laura</creator><creator>Bedogni, Giorgio</creator><creator>Saccomanno, Stefania</creator><creator>Marini, Francesco</creator><creator>Bellentani, Stefano</creator><creator>Barbera, Carmelo</creator><creator>De Minicis, Samuele</creator><creator>Rychlicki, Chiara</creator><creator>Santinelli, Alfredo</creator><creator>Ferretti, Maurizio</creator><creator>Di Maira, Pier Vittorio</creator><creator>Baroni, Gianluca Svegliati</creator><creator>Benedetti, Antonio</creator><creator>Caletti, Giancarlo</creator><creator>Lorenzini, Ivano</creator><creator>Fusaroli, Pietro</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2836-8870</orcidid></search><sort><creationdate>20150201</creationdate><title>PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: Perspectives in the diagnosis of pancreatic cancer</title><author>Marzioni, Marco ; Germani, Ugo ; Agostinelli, Laura ; Bedogni, Giorgio ; Saccomanno, Stefania ; Marini, Francesco ; Bellentani, Stefano ; Barbera, Carmelo ; De Minicis, Samuele ; Rychlicki, Chiara ; Santinelli, Alfredo ; Ferretti, Maurizio ; Di Maira, Pier Vittorio ; Baroni, Gianluca Svegliati ; Benedetti, Antonio ; Caletti, Giancarlo ; Lorenzini, Ivano ; Fusaroli, Pietro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-b46cc994d655d300483b45003f3666b3732ebdb5011a0943922a1cf8f063cf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Carcinoma, Pancreatic Ductal - diagnosis</topic><topic>Carcinoma, Pancreatic Ductal - genetics</topic><topic>Case-Control Studies</topic><topic>Cystadenocarcinoma, Mucinous - diagnosis</topic><topic>Cystadenocarcinoma, Mucinous - genetics</topic><topic>Cystadenocarcinoma, Serous - diagnosis</topic><topic>Cystadenocarcinoma, Serous - genetics</topic><topic>Endoscopic Ultrasound-Guided Fine Needle Aspiration</topic><topic>EUS</topic><topic>Female</topic><topic>FNA</topic><topic>Gastroenterology and Hepatology</topic><topic>Homeodomain Proteins - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Pseudocyst - diagnosis</topic><topic>Pancreatitis, Chronic - diagnosis</topic><topic>PDX-1</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Sensitivity</topic><topic>Specificity</topic><topic>Trans-Activators - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marzioni, Marco</creatorcontrib><creatorcontrib>Germani, Ugo</creatorcontrib><creatorcontrib>Agostinelli, Laura</creatorcontrib><creatorcontrib>Bedogni, Giorgio</creatorcontrib><creatorcontrib>Saccomanno, Stefania</creatorcontrib><creatorcontrib>Marini, Francesco</creatorcontrib><creatorcontrib>Bellentani, Stefano</creatorcontrib><creatorcontrib>Barbera, Carmelo</creatorcontrib><creatorcontrib>De Minicis, Samuele</creatorcontrib><creatorcontrib>Rychlicki, Chiara</creatorcontrib><creatorcontrib>Santinelli, Alfredo</creatorcontrib><creatorcontrib>Ferretti, Maurizio</creatorcontrib><creatorcontrib>Di Maira, Pier Vittorio</creatorcontrib><creatorcontrib>Baroni, Gianluca Svegliati</creatorcontrib><creatorcontrib>Benedetti, Antonio</creatorcontrib><creatorcontrib>Caletti, Giancarlo</creatorcontrib><creatorcontrib>Lorenzini, Ivano</creatorcontrib><creatorcontrib>Fusaroli, Pietro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marzioni, Marco</au><au>Germani, Ugo</au><au>Agostinelli, Laura</au><au>Bedogni, Giorgio</au><au>Saccomanno, Stefania</au><au>Marini, Francesco</au><au>Bellentani, Stefano</au><au>Barbera, Carmelo</au><au>De Minicis, Samuele</au><au>Rychlicki, Chiara</au><au>Santinelli, Alfredo</au><au>Ferretti, Maurizio</au><au>Di Maira, Pier Vittorio</au><au>Baroni, Gianluca Svegliati</au><au>Benedetti, Antonio</au><au>Caletti, Giancarlo</au><au>Lorenzini, Ivano</au><au>Fusaroli, Pietro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: Perspectives in the diagnosis of pancreatic cancer</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>47</volume><issue>2</issue><spage>138</spage><epage>143</epage><pages>138-143</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Abstract Background and aims Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to verify whether the assessment of PDX-1 in endoscopic ultrasound-guided fine needle aspiration samples may be helpful for the diagnosis of pancreatic cancer. Methods mRNA of 54 pancreatic cancer and 25 cystic lesions was extracted. PDX-1 expression was assessed by Real-Time PCR. Results In all but two patients with pancreatic cancer, PDX-1 was expressed and was found positive in 7 patients with pancreatic cancer in which cytology was negative. The positivity was associated with a probability of 0.98 (95% CI 0.90–1.00) of having cancer and the negativity with one of 0.08 (95% CI 0.01–0.27). The probability of cancer rose to 1.00 (95% CI 0.97–1.00) for patients positive to both PDX-1 and cytology and fell to 0.0 (95% CI 0.00–0.15) in patients negative for both. Conclusions PDX-1mRNA is detectable in samples of pancreatic cancer. Its quantification may be helpful to improve the diagnosis of pancreatic cancer.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25454709</pmid><doi>10.1016/j.dld.2014.10.010</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2836-8870</orcidid></addata></record> |
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| subjects | Aged Carcinoma, Pancreatic Ductal - diagnosis Carcinoma, Pancreatic Ductal - genetics Case-Control Studies Cystadenocarcinoma, Mucinous - diagnosis Cystadenocarcinoma, Mucinous - genetics Cystadenocarcinoma, Serous - diagnosis Cystadenocarcinoma, Serous - genetics Endoscopic Ultrasound-Guided Fine Needle Aspiration EUS Female FNA Gastroenterology and Hepatology Homeodomain Proteins - genetics Humans Male Middle Aged Pancreatic cancer Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - genetics Pancreatic Pseudocyst - diagnosis Pancreatitis, Chronic - diagnosis PDX-1 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sensitivity Specificity Trans-Activators - genetics |
| title | PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: Perspectives in the diagnosis of pancreatic cancer |
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