Dysfunction of phospholipase Cγ in immune disorders and cancer

•New evidence for disease-linked mutations in phospholipase Cγ (PLCγ).•The molecular mechanism of dysfunction involves impact on autoinhibition. The surge in genetic and genomic investigations over the past 5 years has resulted in many discoveries of causative variants relevant to disease pathophysi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2014-12, Vol.39 (12), p.603-611
Hauptverfasser:	Koss, Hans, Bunney, Tom D., Behjati, Sam, Katan, Matilda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer deregulation of signaling Diglycerides - metabolism disease-linked mutations Humans immune disorders Immune System Diseases - immunology Immune System Diseases - metabolism Inositol 1,4,5-Trisphosphate - metabolism Models, Biological Models, Molecular Mutation Neoplasms - genetics Neoplasms - metabolism phospholipase C Phospholipase C gamma - chemistry Phospholipase C gamma - genetics Phospholipase C gamma - metabolism Protein Conformation Second Messenger Systems
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!