Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina
Measurement and imaging of depolarization by polarization-sensitive optical coherence tomography (PS-OCT) requires averaging of Stokes vector elements within two- or three-dimensional (3-D) evaluation windows to obtain the degree of polarization uniformity (DOPU). By use of a PS-OCT system with an i...
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| Veröffentlicht in: | Journal of biomedical optics 2015-01, Vol.20 (1), p.016011-016011 |
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| container_title | Journal of biomedical optics |
| container_volume | 20 |
| creator | Sugita, Mitsuro Pircher, Michael Zotter, Stefan Baumann, Bernhard Saito, Kenichi Makihira, Tomoyuki Tomatsu, Nobuhiro Sato, Makoto Hitzenberger, Christoph K |
| description | Measurement and imaging of depolarization by polarization-sensitive optical coherence tomography (PS-OCT) requires averaging of Stokes vector elements within two- or three-dimensional (3-D) evaluation windows to obtain the degree of polarization uniformity (DOPU). By use of a PS-OCT system with an integrated retinal tracker, we analyze optimum conditions for depolarization imaging, data processing, and segmentation of depolarizing tissue in the human retina. The trade-offs between figures of merit like DOPU imaging sensitivity, efficiency, and susceptibility are evaluated in terms of 3-D resolution. The results are used for a new, detailed interpretation of PS-OCT high-resolution images of the human retinal pigment epithelium and Bruch's membrane. |
| doi_str_mv | 10.1117/1.JBO.20.1.016011 |
| format | Article |
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The results are used for a new, detailed interpretation of PS-OCT high-resolution images of the human retinal pigment epithelium and Bruch's membrane.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.JBO.20.1.016011</identifier><identifier>PMID: 25585024</identifier><language>eng</language><publisher>United States: Society of Photo-Optical Instrumentation Engineers</publisher><subject>Depolarization ; Figure of merit ; Human ; Humans ; Image Processing, Computer-Assisted - methods ; Imaging ; Models, Biological ; Optical Coherence Tomography ; Optimization ; Retina ; Retina - anatomy & histology ; Segmentation ; Signal-To-Noise Ratio ; Three dimensional ; Tomography, Optical Coherence - methods</subject><ispartof>Journal of biomedical optics, 2015-01, Vol.20 (1), p.016011-016011</ispartof><rights>The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-17e093b02d6acd0f67e891e15407dd21b14a2ac0e5fa10afd8c2c9a90c1bb17c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25585024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugita, Mitsuro</creatorcontrib><creatorcontrib>Pircher, Michael</creatorcontrib><creatorcontrib>Zotter, Stefan</creatorcontrib><creatorcontrib>Baumann, Bernhard</creatorcontrib><creatorcontrib>Saito, Kenichi</creatorcontrib><creatorcontrib>Makihira, Tomoyuki</creatorcontrib><creatorcontrib>Tomatsu, Nobuhiro</creatorcontrib><creatorcontrib>Sato, Makoto</creatorcontrib><creatorcontrib>Hitzenberger, Christoph K</creatorcontrib><title>Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina</title><title>Journal of biomedical optics</title><addtitle>J. Biomed. Opt</addtitle><description>Measurement and imaging of depolarization by polarization-sensitive optical coherence tomography (PS-OCT) requires averaging of Stokes vector elements within two- or three-dimensional (3-D) evaluation windows to obtain the degree of polarization uniformity (DOPU). By use of a PS-OCT system with an integrated retinal tracker, we analyze optimum conditions for depolarization imaging, data processing, and segmentation of depolarizing tissue in the human retina. The trade-offs between figures of merit like DOPU imaging sensitivity, efficiency, and susceptibility are evaluated in terms of 3-D resolution. The results are used for a new, detailed interpretation of PS-OCT high-resolution images of the human retinal pigment epithelium and Bruch's membrane.</description><subject>Depolarization</subject><subject>Figure of merit</subject><subject>Human</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Models, Biological</subject><subject>Optical Coherence Tomography</subject><subject>Optimization</subject><subject>Retina</subject><subject>Retina - anatomy & histology</subject><subject>Segmentation</subject><subject>Signal-To-Noise Ratio</subject><subject>Three dimensional</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxSNERf_AB-CCfOSS4HFiJzkuLS2gSuUAXC3Hnuy6SuxgJ0jbK18cd7fQSi1CPtjz_Oan0bwsew20AID6HRSf318VLFUFBUEBnmVHwAXNGWvgeXrTpsxLIZrD7DjGa0ppI1rxIjtknDecsuoo-7VyathGG4nviZ9mOy4j0d4ZO1vvdqrByQ8q2Bt1KxE7qrV1a9JtyUM9j-hiavqJO4xWQ8JsMKDTSGY_-nVQ02ZLrCPzBslmGZUjAWfr1MvsoFdDxFd390n27fzD19OP-eXVxafT1WWuuYA5hxppW3aUGaG0ob2osWkBgVe0NoZBB5ViSlPkvQKqetNoplvVUg1dB7UuT7K3e-4U_I8F4yxHGzUOg3LolyihppBO1fL_WwVnZStEWyUr7K06-BgD9nIKaUdhK4HK25gkyBSTZKmS-5hSz5s7_NKNaP52_MklGb7vDXGyKK_9ElJM8Z5zY6fH2J26Cmn5A345O3_0PZk-gYunwP8e9TfaRbsY</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Sugita, Mitsuro</creator><creator>Pircher, Michael</creator><creator>Zotter, Stefan</creator><creator>Baumann, Bernhard</creator><creator>Saito, Kenichi</creator><creator>Makihira, Tomoyuki</creator><creator>Tomatsu, Nobuhiro</creator><creator>Sato, Makoto</creator><creator>Hitzenberger, Christoph K</creator><general>Society of Photo-Optical Instrumentation Engineers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>20150101</creationdate><title>Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina</title><author>Sugita, Mitsuro ; Pircher, Michael ; Zotter, Stefan ; Baumann, Bernhard ; Saito, Kenichi ; Makihira, Tomoyuki ; Tomatsu, Nobuhiro ; Sato, Makoto ; Hitzenberger, Christoph K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-17e093b02d6acd0f67e891e15407dd21b14a2ac0e5fa10afd8c2c9a90c1bb17c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Depolarization</topic><topic>Figure of merit</topic><topic>Human</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Models, Biological</topic><topic>Optical Coherence Tomography</topic><topic>Optimization</topic><topic>Retina</topic><topic>Retina - anatomy & histology</topic><topic>Segmentation</topic><topic>Signal-To-Noise Ratio</topic><topic>Three dimensional</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugita, Mitsuro</creatorcontrib><creatorcontrib>Pircher, Michael</creatorcontrib><creatorcontrib>Zotter, Stefan</creatorcontrib><creatorcontrib>Baumann, Bernhard</creatorcontrib><creatorcontrib>Saito, Kenichi</creatorcontrib><creatorcontrib>Makihira, Tomoyuki</creatorcontrib><creatorcontrib>Tomatsu, Nobuhiro</creatorcontrib><creatorcontrib>Sato, Makoto</creatorcontrib><creatorcontrib>Hitzenberger, Christoph K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of biomedical optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugita, Mitsuro</au><au>Pircher, Michael</au><au>Zotter, Stefan</au><au>Baumann, Bernhard</au><au>Saito, Kenichi</au><au>Makihira, Tomoyuki</au><au>Tomatsu, Nobuhiro</au><au>Sato, Makoto</au><au>Hitzenberger, Christoph K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina</atitle><jtitle>Journal of biomedical optics</jtitle><addtitle>J. Biomed. Opt</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>20</volume><issue>1</issue><spage>016011</spage><epage>016011</epage><pages>016011-016011</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><abstract>Measurement and imaging of depolarization by polarization-sensitive optical coherence tomography (PS-OCT) requires averaging of Stokes vector elements within two- or three-dimensional (3-D) evaluation windows to obtain the degree of polarization uniformity (DOPU). By use of a PS-OCT system with an integrated retinal tracker, we analyze optimum conditions for depolarization imaging, data processing, and segmentation of depolarizing tissue in the human retina. The trade-offs between figures of merit like DOPU imaging sensitivity, efficiency, and susceptibility are evaluated in terms of 3-D resolution. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Depolarization Figure of merit Human Humans Image Processing, Computer-Assisted - methods Imaging Models, Biological Optical Coherence Tomography Optimization Retina Retina - anatomy & histology Segmentation Signal-To-Noise Ratio Three dimensional Tomography, Optical Coherence - methods |
| title | Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina |
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