Impact of the discovery of human zinc deficiency on health
The essentiality of zinc in humans was established in 1963. During the past 50y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. Growth retardation; cell-mediated immune dysfunction, and cognitive impairment are major clinical effects in human...
Gespeichert in:
| Veröffentlicht in: | Journal of trace elements in medicine and biology 2014-10, Vol.28 (4), p.357-363 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 363 |
|---|---|
| container_issue | 4 |
| container_start_page | 357 |
| container_title | Journal of trace elements in medicine and biology |
| container_volume | 28 |
| creator | Prasad, Ananda S. |
| description | The essentiality of zinc in humans was established in 1963. During the past 50y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. Growth retardation; cell-mediated immune dysfunction, and cognitive impairment are major clinical effects in human. At present we know of >300 enzymes and >1000 transcription factors that require zinc for their activities. Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent. Zinc supplementation in the elderly results in decreased incidence of infections, decreased oxidative stress and decreased generation of inflammatory cytokines. |
| doi_str_mv | 10.1016/j.jtemb.2014.09.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652395405</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0946672X14001710</els_id><sourcerecordid>1652395405</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-d1b6b3520f84218df892be83d13b9e697c5e5b68c56049903eb4a6d2120b41603</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMozjj6CwTp0k3rTdpkEsGFDD4GBtwouAtNcktb-hibdmD89XYeunR14Z5z7uMj5JpCRIGKuzIqe6xNxIAmEagIgJ2QKZVzGcaMs1MyBZWIUMzZ54RceF8C0DmX7JxMRlmAlHxK7pf1OrV90GZBn2PgCm_bDXbbXSMf6rQJvovGBg6zwhbY2FFoghzTqs8vyVmWVh6vjnVGPp6f3hev4ertZbl4XIU2UbwPHTXCxJxBJhNGpcukYgZl7GhsFAo1txy5EdJyAYlSEKNJUuEYZWASKiCekdvD3HXXfg3oe12PV2JVpQ22g9dUcBYrngAfrfHBarvW-w4zve6KOu22moLeQdOl3kPTO2galB6hjamb44LB1Oj-Mr-URsPDwYDjm5sCO-33MNAVHdpeu7b4d8EPaqx8wg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652395405</pqid></control><display><type>article</type><title>Impact of the discovery of human zinc deficiency on health</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Prasad, Ananda S.</creator><creatorcontrib>Prasad, Ananda S.</creatorcontrib><description>The essentiality of zinc in humans was established in 1963. During the past 50y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. Growth retardation; cell-mediated immune dysfunction, and cognitive impairment are major clinical effects in human. At present we know of >300 enzymes and >1000 transcription factors that require zinc for their activities. Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent. Zinc supplementation in the elderly results in decreased incidence of infections, decreased oxidative stress and decreased generation of inflammatory cytokines.</description><identifier>ISSN: 0946-672X</identifier><identifier>EISSN: 1878-3252</identifier><identifier>DOI: 10.1016/j.jtemb.2014.09.002</identifier><identifier>PMID: 25260885</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Anti-inflammatory agent ; Antioxidant ; Dietary Supplements ; Growth retardation ; Hepatolenticular Degeneration - prevention & control ; Humans ; Immunity ; Oxidative Stress - drug effects ; Signal Transduction - drug effects ; Zinc ; Zinc - therapeutic use</subject><ispartof>Journal of trace elements in medicine and biology, 2014-10, Vol.28 (4), p.357-363</ispartof><rights>2014 Elsevier GmbH</rights><rights>Copyright © 2014 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-d1b6b3520f84218df892be83d13b9e697c5e5b68c56049903eb4a6d2120b41603</citedby><cites>FETCH-LOGICAL-c495t-d1b6b3520f84218df892be83d13b9e697c5e5b68c56049903eb4a6d2120b41603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jtemb.2014.09.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25260885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prasad, Ananda S.</creatorcontrib><title>Impact of the discovery of human zinc deficiency on health</title><title>Journal of trace elements in medicine and biology</title><addtitle>J Trace Elem Med Biol</addtitle><description>The essentiality of zinc in humans was established in 1963. During the past 50y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. Growth retardation; cell-mediated immune dysfunction, and cognitive impairment are major clinical effects in human. At present we know of >300 enzymes and >1000 transcription factors that require zinc for their activities. Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent. Zinc supplementation in the elderly results in decreased incidence of infections, decreased oxidative stress and decreased generation of inflammatory cytokines.</description><subject>Anti-inflammatory agent</subject><subject>Antioxidant</subject><subject>Dietary Supplements</subject><subject>Growth retardation</subject><subject>Hepatolenticular Degeneration - prevention & control</subject><subject>Humans</subject><subject>Immunity</subject><subject>Oxidative Stress - drug effects</subject><subject>Signal Transduction - drug effects</subject><subject>Zinc</subject><subject>Zinc - therapeutic use</subject><issn>0946-672X</issn><issn>1878-3252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMozjj6CwTp0k3rTdpkEsGFDD4GBtwouAtNcktb-hibdmD89XYeunR14Z5z7uMj5JpCRIGKuzIqe6xNxIAmEagIgJ2QKZVzGcaMs1MyBZWIUMzZ54RceF8C0DmX7JxMRlmAlHxK7pf1OrV90GZBn2PgCm_bDXbbXSMf6rQJvovGBg6zwhbY2FFoghzTqs8vyVmWVh6vjnVGPp6f3hev4ertZbl4XIU2UbwPHTXCxJxBJhNGpcukYgZl7GhsFAo1txy5EdJyAYlSEKNJUuEYZWASKiCekdvD3HXXfg3oe12PV2JVpQ22g9dUcBYrngAfrfHBarvW-w4zve6KOu22moLeQdOl3kPTO2galB6hjamb44LB1Oj-Mr-URsPDwYDjm5sCO-33MNAVHdpeu7b4d8EPaqx8wg</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Prasad, Ananda S.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Impact of the discovery of human zinc deficiency on health</title><author>Prasad, Ananda S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-d1b6b3520f84218df892be83d13b9e697c5e5b68c56049903eb4a6d2120b41603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anti-inflammatory agent</topic><topic>Antioxidant</topic><topic>Dietary Supplements</topic><topic>Growth retardation</topic><topic>Hepatolenticular Degeneration - prevention & control</topic><topic>Humans</topic><topic>Immunity</topic><topic>Oxidative Stress - drug effects</topic><topic>Signal Transduction - drug effects</topic><topic>Zinc</topic><topic>Zinc - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prasad, Ananda S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of trace elements in medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prasad, Ananda S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of the discovery of human zinc deficiency on health</atitle><jtitle>Journal of trace elements in medicine and biology</jtitle><addtitle>J Trace Elem Med Biol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>28</volume><issue>4</issue><spage>357</spage><epage>363</epage><pages>357-363</pages><issn>0946-672X</issn><eissn>1878-3252</eissn><abstract>The essentiality of zinc in humans was established in 1963. During the past 50y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. Growth retardation; cell-mediated immune dysfunction, and cognitive impairment are major clinical effects in human. At present we know of >300 enzymes and >1000 transcription factors that require zinc for their activities. Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent. Zinc supplementation in the elderly results in decreased incidence of infections, decreased oxidative stress and decreased generation of inflammatory cytokines.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>25260885</pmid><doi>10.1016/j.jtemb.2014.09.002</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0946-672X |
| ispartof | Journal of trace elements in medicine and biology, 2014-10, Vol.28 (4), p.357-363 |
| issn | 0946-672X 1878-3252 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1652395405 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Anti-inflammatory agent Antioxidant Dietary Supplements Growth retardation Hepatolenticular Degeneration - prevention & control Humans Immunity Oxidative Stress - drug effects Signal Transduction - drug effects Zinc Zinc - therapeutic use |
| title | Impact of the discovery of human zinc deficiency on health |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T18%3A04%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20the%20discovery%20of%20human%20zinc%20deficiency%20on%20health&rft.jtitle=Journal%20of%20trace%20elements%20in%20medicine%20and%20biology&rft.au=Prasad,%20Ananda%20S.&rft.date=2014-10-01&rft.volume=28&rft.issue=4&rft.spage=357&rft.epage=363&rft.pages=357-363&rft.issn=0946-672X&rft.eissn=1878-3252&rft_id=info:doi/10.1016/j.jtemb.2014.09.002&rft_dat=%3Cproquest_cross%3E1652395405%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652395405&rft_id=info:pmid/25260885&rft_els_id=S0946672X14001710&rfr_iscdi=true |