Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: Report of 2 cases
Background Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland neoplasm most often found in the oral cavity. Although it is generally a low‐grade malignancy that is treated with wide local excision, there is a growing body of evidence pointing toward the potential for more aggressive be...
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| Veröffentlicht in: | Head & neck 2015-02, Vol.37 (2), p.E19-E21 |
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| container_title | Head & neck |
| container_volume | 37 |
| creator | Su, Henry K. Wang, Beverly Y. Mannan, Abul Ala Syed Rifat Dewey, Eliza H. Alpert, Erin H. Reis, Laura L. Dos Urken, Mark L. Andersen, Peter |
| description | Background
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland neoplasm most often found in the oral cavity. Although it is generally a low‐grade malignancy that is treated with wide local excision, there is a growing body of evidence pointing toward the potential for more aggressive behavior.
Methods
We reviewed available records of patients with delayed cervical lymph node metastases from HCCC.
Results
Two patients who were treated with wide local resection for HCCC and remained disease‐free at the primary site were diagnosed with cervical lymph node metastases 10 and 14 years later. We treated both with neck dissection, and 1 patient received adjuvant radiation therapy.
Conclusion
These cases illustrate the risk for occult nodal metastases from HCCC with delayed presentation. Clinician awareness of the presence of subclinical metastases in the neck requires thorough long‐term surveillance and potential intervention should nodal disease become manifest. © 2014 Wiley Periodicals, Inc. Head Neck 37: E19‐E21, 2015 |
| doi_str_mv | 10.1002/hed.23764 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652391140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3562343131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4894-e393a33d8c0c3157d38c030d5567d52856bf709f8af930cdc5bd0c464d61e3073</originalsourceid><addsrcrecordid>eNp1kElLBDEQhYMo7gf_gAS86KG1svXiTdxGGBBEvTaZpNppSXfGZEZpf70ZRy-CUFBF8dXj1SPkgMEpA-BnU7SnXBS5XCPbDKoiAyGL9eUsRSagkFtkJ8ZXABC55Jtki8uSSynKbWKfMQzUotMDWmowvLdGO-qGbjalvbdIO5zrmAojbYLv6HTQru3bz7Z_ocahDunKOWp0MG3vO31OH3Dmw5z6hvK0Tod7ZKPRLuL-T98lTzfXj5ejbHx_e3d5Mc6MLCuZoaiEFsKWBoxgqrAiTQKsUnlhFS9VPmkKqJpSN5UAY42aWDAylzZnmN4Uu-R4pTsL_m2BcV53bVy60z36RaxZrrioGJOQ0KM_6KtfhD65S5TMVck5qESdrCgTfIwBm3oW2k6HoWZQL6OvU_T1d_SJPfxRXEy6tP0lf7NOwNkK-GgdDv8r1aPrq5XkF1P-jBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1646582205</pqid></control><display><type>article</type><title>Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: Report of 2 cases</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Su, Henry K. ; Wang, Beverly Y. ; Mannan, Abul Ala Syed Rifat ; Dewey, Eliza H. ; Alpert, Erin H. ; Reis, Laura L. Dos ; Urken, Mark L. ; Andersen, Peter</creator><creatorcontrib>Su, Henry K. ; Wang, Beverly Y. ; Mannan, Abul Ala Syed Rifat ; Dewey, Eliza H. ; Alpert, Erin H. ; Reis, Laura L. Dos ; Urken, Mark L. ; Andersen, Peter</creatorcontrib><description>Background
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland neoplasm most often found in the oral cavity. Although it is generally a low‐grade malignancy that is treated with wide local excision, there is a growing body of evidence pointing toward the potential for more aggressive behavior.
Methods
We reviewed available records of patients with delayed cervical lymph node metastases from HCCC.
Results
Two patients who were treated with wide local resection for HCCC and remained disease‐free at the primary site were diagnosed with cervical lymph node metastases 10 and 14 years later. We treated both with neck dissection, and 1 patient received adjuvant radiation therapy.
Conclusion
These cases illustrate the risk for occult nodal metastases from HCCC with delayed presentation. Clinician awareness of the presence of subclinical metastases in the neck requires thorough long‐term surveillance and potential intervention should nodal disease become manifest. © 2014 Wiley Periodicals, Inc. Head Neck 37: E19‐E21, 2015</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23764</identifier><identifier>PMID: 24824438</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma, Clear Cell - pathology ; Adult ; clear cell carcinoma ; delayed metastases ; Female ; Humans ; hyalinizing ; lymph node metastases ; Lymphatic Metastasis ; Middle Aged ; salivary gland ; Salivary Gland Neoplasms - pathology ; Time Factors</subject><ispartof>Head & neck, 2015-02, Vol.37 (2), p.E19-E21</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4894-e393a33d8c0c3157d38c030d5567d52856bf709f8af930cdc5bd0c464d61e3073</citedby><cites>FETCH-LOGICAL-c4894-e393a33d8c0c3157d38c030d5567d52856bf709f8af930cdc5bd0c464d61e3073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23764$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23764$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24824438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Henry K.</creatorcontrib><creatorcontrib>Wang, Beverly Y.</creatorcontrib><creatorcontrib>Mannan, Abul Ala Syed Rifat</creatorcontrib><creatorcontrib>Dewey, Eliza H.</creatorcontrib><creatorcontrib>Alpert, Erin H.</creatorcontrib><creatorcontrib>Reis, Laura L. Dos</creatorcontrib><creatorcontrib>Urken, Mark L.</creatorcontrib><creatorcontrib>Andersen, Peter</creatorcontrib><title>Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: Report of 2 cases</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland neoplasm most often found in the oral cavity. Although it is generally a low‐grade malignancy that is treated with wide local excision, there is a growing body of evidence pointing toward the potential for more aggressive behavior.
Methods
We reviewed available records of patients with delayed cervical lymph node metastases from HCCC.
Results
Two patients who were treated with wide local resection for HCCC and remained disease‐free at the primary site were diagnosed with cervical lymph node metastases 10 and 14 years later. We treated both with neck dissection, and 1 patient received adjuvant radiation therapy.
Conclusion
These cases illustrate the risk for occult nodal metastases from HCCC with delayed presentation. Clinician awareness of the presence of subclinical metastases in the neck requires thorough long‐term surveillance and potential intervention should nodal disease become manifest. © 2014 Wiley Periodicals, Inc. Head Neck 37: E19‐E21, 2015</description><subject>Adenocarcinoma, Clear Cell - pathology</subject><subject>Adult</subject><subject>clear cell carcinoma</subject><subject>delayed metastases</subject><subject>Female</subject><subject>Humans</subject><subject>hyalinizing</subject><subject>lymph node metastases</subject><subject>Lymphatic Metastasis</subject><subject>Middle Aged</subject><subject>salivary gland</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Time Factors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kElLBDEQhYMo7gf_gAS86KG1svXiTdxGGBBEvTaZpNppSXfGZEZpf70ZRy-CUFBF8dXj1SPkgMEpA-BnU7SnXBS5XCPbDKoiAyGL9eUsRSagkFtkJ8ZXABC55Jtki8uSSynKbWKfMQzUotMDWmowvLdGO-qGbjalvbdIO5zrmAojbYLv6HTQru3bz7Z_ocahDunKOWp0MG3vO31OH3Dmw5z6hvK0Tod7ZKPRLuL-T98lTzfXj5ejbHx_e3d5Mc6MLCuZoaiEFsKWBoxgqrAiTQKsUnlhFS9VPmkKqJpSN5UAY42aWDAylzZnmN4Uu-R4pTsL_m2BcV53bVy60z36RaxZrrioGJOQ0KM_6KtfhD65S5TMVck5qESdrCgTfIwBm3oW2k6HoWZQL6OvU_T1d_SJPfxRXEy6tP0lf7NOwNkK-GgdDv8r1aPrq5XkF1P-jBQ</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Su, Henry K.</creator><creator>Wang, Beverly Y.</creator><creator>Mannan, Abul Ala Syed Rifat</creator><creator>Dewey, Eliza H.</creator><creator>Alpert, Erin H.</creator><creator>Reis, Laura L. Dos</creator><creator>Urken, Mark L.</creator><creator>Andersen, Peter</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: Report of 2 cases</title><author>Su, Henry K. ; Wang, Beverly Y. ; Mannan, Abul Ala Syed Rifat ; Dewey, Eliza H. ; Alpert, Erin H. ; Reis, Laura L. Dos ; Urken, Mark L. ; Andersen, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4894-e393a33d8c0c3157d38c030d5567d52856bf709f8af930cdc5bd0c464d61e3073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma, Clear Cell - pathology</topic><topic>Adult</topic><topic>clear cell carcinoma</topic><topic>delayed metastases</topic><topic>Female</topic><topic>Humans</topic><topic>hyalinizing</topic><topic>lymph node metastases</topic><topic>Lymphatic Metastasis</topic><topic>Middle Aged</topic><topic>salivary gland</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Henry K.</creatorcontrib><creatorcontrib>Wang, Beverly Y.</creatorcontrib><creatorcontrib>Mannan, Abul Ala Syed Rifat</creatorcontrib><creatorcontrib>Dewey, Eliza H.</creatorcontrib><creatorcontrib>Alpert, Erin H.</creatorcontrib><creatorcontrib>Reis, Laura L. Dos</creatorcontrib><creatorcontrib>Urken, Mark L.</creatorcontrib><creatorcontrib>Andersen, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Henry K.</au><au>Wang, Beverly Y.</au><au>Mannan, Abul Ala Syed Rifat</au><au>Dewey, Eliza H.</au><au>Alpert, Erin H.</au><au>Reis, Laura L. Dos</au><au>Urken, Mark L.</au><au>Andersen, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: Report of 2 cases</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2015-02</date><risdate>2015</risdate><volume>37</volume><issue>2</issue><spage>E19</spage><epage>E21</epage><pages>E19-E21</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland neoplasm most often found in the oral cavity. Although it is generally a low‐grade malignancy that is treated with wide local excision, there is a growing body of evidence pointing toward the potential for more aggressive behavior.
Methods
We reviewed available records of patients with delayed cervical lymph node metastases from HCCC.
Results
Two patients who were treated with wide local resection for HCCC and remained disease‐free at the primary site were diagnosed with cervical lymph node metastases 10 and 14 years later. We treated both with neck dissection, and 1 patient received adjuvant radiation therapy.
Conclusion
These cases illustrate the risk for occult nodal metastases from HCCC with delayed presentation. Clinician awareness of the presence of subclinical metastases in the neck requires thorough long‐term surveillance and potential intervention should nodal disease become manifest. © 2014 Wiley Periodicals, Inc. Head Neck 37: E19‐E21, 2015</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24824438</pmid><doi>10.1002/hed.23764</doi><tpages>3</tpages></addata></record> |
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| ispartof | Head & neck, 2015-02, Vol.37 (2), p.E19-E21 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adenocarcinoma, Clear Cell - pathology Adult clear cell carcinoma delayed metastases Female Humans hyalinizing lymph node metastases Lymphatic Metastasis Middle Aged salivary gland Salivary Gland Neoplasms - pathology Time Factors |
| title | Very delayed cervical lymph node metastases from hyalinizing clear cell carcinoma: Report of 2 cases |
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