Overexpression of G9a and MCM7 in oesophageal squamous cell carcinoma is associated with poor prognosis

Aims Histone methyltransferase G9a has been primarily understood as a co‐repressor of gene expression, but it has been shown that G9a also positively regulates nuclear receptor‐mediated transcription. MCM7, a critical component of the DNA replication licensing complex, is amplified and overexpressed...

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Veröffentlicht in:	Histopathology 2015-01, Vol.66 (2), p.192-200
Hauptverfasser:	Zhong, Xinwen, Chen, Xiaolong, Guan, Xiaojiao, Zhang, Heng, Ma, Yinan, Zhang, Shuguang, Wang, Enhua, Zhang, Lin, Han, Yuchen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Blotting, Western Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Female G9a Histocompatibility Antigens - biosynthesis Histone-Lysine N-Methyltransferase - biosynthesis Humans Immunohistochemistry Kaplan-Meier Estimate Male MCM7 Middle Aged Minichromosome Maintenance Complex Component 7 - biosynthesis oesophageal squamous cell carcinoma Prognosis RNA, Small Interfering Tissue Array Analysis
Online-Zugang:	Volltext
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