Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy

Diabetes affects cardiac structure and function, and it has been suggested that diabetes leads to cardiomyopathy. Arachidonate 12/15-lipoxygenase (LOX) has been suggested to play an important role in atherogenesis and heart failure. However, the role of 12/15-LOX in diabetic cardiomyopathy has not b...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2015-02, Vol.64 (2), p.618-630
Hauptverfasser:	Suzuki, Hirofumi, Kayama, Yosuke, Sakamoto, Masaya, Iuchi, Hiroyuki, Shimizu, Ippei, Yoshino, Takuya, Katoh, Daisuke, Nagoshi, Tomohisa, Tojo, Katsuyoshi, Minamino, Tohru, Yoshimura, Michihiro, Utsunomiya, Kazunori
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Animals Arachidonate 12-Lipoxygenase - genetics Arachidonate 12-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase - genetics Arachidonate 15-Lipoxygenase - metabolism Blood Glucose Cardiomyopathy Diabetes Diabetes Mellitus, Experimental - complications Diabetic Cardiomyopathies - etiology Diabetic Cardiomyopathies - metabolism Fibrosis - etiology Gene Expression Regulation, Enzymologic Glucose Heart failure Hyperglycemia - complications Inflammation - metabolism Mice Mice, Knockout Oxidative stress Oxidative Stress - physiology Rodents TNF inhibitors Up-Regulation
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