What we know and do not know about the cannabinoid receptor 2 (CB2)

Highlights • CB2 is highly expressed by cells of the immune system and can be immunosuppressive. • CB2 is a member of the G-protein coupled receptor family and binds eicosanoid ligands. • Endogenous cannabinoids that bind CB2 are ananamide and 2-arachidonoyl glycerol. • Cannabinoids have therapeutic...

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Veröffentlicht in:	Seminars in immunology 2014-10, Vol.26 (5), p.369-379
Hauptverfasser:	Malfitano, Anna Maria, Basu, Sreemanti, Maresz, Katarzyna, Bifulco, Maurizio, Dittel, Bonnie N
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cannabinoid receptor 2 Central Nervous System - immunology Central Nervous System - metabolism Cytokines - genetics Cytokines - immunology Cytokines - metabolism Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Endocannabinoid Endocannabinoids - immunology Endocannabinoids - metabolism Gene Expression Regulation Humans Immune regulatory Immune System - metabolism Knockout Lymphocytes - immunology Lymphocytes - metabolism Lymphocytes - pathology Macrophages - immunology Macrophages - metabolism Macrophages - pathology Mice Osteoporosis - genetics Osteoporosis - immunology Osteoporosis - metabolism Osteoporosis - pathology Plants - genetics Plants - metabolism Polymorphism Receptor, Cannabinoid, CB2 - genetics Receptor, Cannabinoid, CB2 - immunology Receptor, Cannabinoid, CB2 - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - immunology Receptors, G-Protein-Coupled - metabolism Signal Transduction
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