Kinetics of mesenchymal and hematopoietic stem cells mobilization by G-CSF and its impact on the cytokine microenvironment in primary cultures

•G-CSF administration increases the frequency of stem cells.•G-CSF administration potentiates stem cells to release soluble factors.•Stem cells harvested from bone marrow and peripheral blood display differential functional properties.•Stem cells are promises for future clinical applications and reg...

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Veröffentlicht in:	Cellular immunology 2015-01, Vol.293 (1), p.1-9
Hauptverfasser:	Garcia, Nadja Pinto, de Leon, Elisa Brosina, da Costa, Allyson Guimarães, Tarragô, Andréa Monteiro, Pimentel, João Paulo, Fraporti, Liziara, de Araujo, Fernanda Fortes, Campos, Fernanda Magalhães Freire, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Malheiro, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Cytokines Dose-Response Relationship, Immunologic Female Granulocyte Colony-Stimulating Factor - pharmacology Hematopoietic Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - immunology Immunophenotyping Interleukin-10 - biosynthesis Interleukin-10 - secretion Interleukin-17 - biosynthesis Interleukin-17 - secretion Interleukin-2 - biosynthesis Interleukin-2 - secretion Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Mesenchymal Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - immunology Mice Primary Cell Culture Stem cells mobilization Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - secretion
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