Potential Impact of Air Pollution on Multiple Sclerosis in Tehran, Iran
Background: Multiple sclerosis (MS) incidence has dramatically increased in Tehran, Iran. The health impact of air pollution in Tehran underscores the attention to a possible association to this environmental risk factor. In this study, the authors aimed to analyze the spatial distribution of preval...
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| Veröffentlicht in: | Neuroepidemiology 2014-01, Vol.43 (3-4), p.233-238 |
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| creator | Heydarpour, Pouria Amini, Hassan Khoshkish, Shayan Seidkhani, Hossein Sahraian, Mohammad Ali Yunesian, Masud |
| description | Background: Multiple sclerosis (MS) incidence has dramatically increased in Tehran, Iran. The health impact of air pollution in Tehran underscores the attention to a possible association to this environmental risk factor. In this study, the authors aimed to analyze the spatial distribution of prevalent MS cases and their association with the spatial patterns of air pollution. Methods: Patient records meeting McDonald's criteria for definite MS diagnosis with disease onset during 2003-2013 were obtained. Next, the location of 2,188 patients was successfully geo-referenced within Tehran metropolis by geographic information system (GIS) bureau of Iran's post office based on their phone numbers. A cluster analysis was performed using the average nearest neighbor index (ANNI) and quadrat analysis. The long-term exposures of MS patients to particulate matter (PM 10 ), sulfur dioxide (SO 2 ), nitrogen oxide (NO), nitrogen dioxide (NO 2 ), and nitrogen oxides (NOx) were estimated using the previously developed land use regression models. Results: Prevalent MS cases had a clustered pattern in Tehran. A significant difference in exposure to PM 10 , SO 2 , NO 2 , and NOx (p < 0.001) was observed in MS cases compared with controls. Conclusion: This study revealed the potential role of long-term exposure to air pollutants as an environmental risk factor in MS. |
| doi_str_mv | 10.1159/000368553 |
| format | Article |
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The health impact of air pollution in Tehran underscores the attention to a possible association to this environmental risk factor. In this study, the authors aimed to analyze the spatial distribution of prevalent MS cases and their association with the spatial patterns of air pollution. Methods: Patient records meeting McDonald's criteria for definite MS diagnosis with disease onset during 2003-2013 were obtained. Next, the location of 2,188 patients was successfully geo-referenced within Tehran metropolis by geographic information system (GIS) bureau of Iran's post office based on their phone numbers. A cluster analysis was performed using the average nearest neighbor index (ANNI) and quadrat analysis. The long-term exposures of MS patients to particulate matter (PM 10 ), sulfur dioxide (SO 2 ), nitrogen oxide (NO), nitrogen dioxide (NO 2 ), and nitrogen oxides (NOx) were estimated using the previously developed land use regression models. Results: Prevalent MS cases had a clustered pattern in Tehran. A significant difference in exposure to PM 10 , SO 2 , NO 2 , and NOx (p < 0.001) was observed in MS cases compared with controls. Conclusion: This study revealed the potential role of long-term exposure to air pollutants as an environmental risk factor in MS.</description><identifier>ISSN: 0251-5350</identifier><identifier>EISSN: 1423-0208</identifier><identifier>DOI: 10.1159/000368553</identifier><identifier>PMID: 25501708</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Air pollution ; Air Pollution - adverse effects ; Cluster Analysis ; Environmental aspects ; Environmental Exposure - adverse effects ; Geographic Mapping ; Health aspects ; Humans ; Iran ; Multiple sclerosis ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - etiology ; Original Paper ; Prevalence ; Risk Factors ; Statistics</subject><ispartof>Neuroepidemiology, 2014-01, Vol.43 (3-4), p.233-238</ispartof><rights>2014 S. Karger AG, Basel</rights><rights>2014 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2015 S. Karger AG</rights><rights>Copyright (c) 2015 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-29abfe608408befc06f577acd86584a18fead7fc40f916c59b21883cda30ab473</citedby><cites>FETCH-LOGICAL-c400t-29abfe608408befc06f577acd86584a18fead7fc40f916c59b21883cda30ab473</cites><orcidid>0000-0001-5644-7555 ; 0000-0002-2870-7433</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25501708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heydarpour, Pouria</creatorcontrib><creatorcontrib>Amini, Hassan</creatorcontrib><creatorcontrib>Khoshkish, Shayan</creatorcontrib><creatorcontrib>Seidkhani, Hossein</creatorcontrib><creatorcontrib>Sahraian, Mohammad Ali</creatorcontrib><creatorcontrib>Yunesian, Masud</creatorcontrib><title>Potential Impact of Air Pollution on Multiple Sclerosis in Tehran, Iran</title><title>Neuroepidemiology</title><addtitle>Neuroepidemiology</addtitle><description>Background: Multiple sclerosis (MS) incidence has dramatically increased in Tehran, Iran. The health impact of air pollution in Tehran underscores the attention to a possible association to this environmental risk factor. In this study, the authors aimed to analyze the spatial distribution of prevalent MS cases and their association with the spatial patterns of air pollution. Methods: Patient records meeting McDonald's criteria for definite MS diagnosis with disease onset during 2003-2013 were obtained. Next, the location of 2,188 patients was successfully geo-referenced within Tehran metropolis by geographic information system (GIS) bureau of Iran's post office based on their phone numbers. A cluster analysis was performed using the average nearest neighbor index (ANNI) and quadrat analysis. The long-term exposures of MS patients to particulate matter (PM 10 ), sulfur dioxide (SO 2 ), nitrogen oxide (NO), nitrogen dioxide (NO 2 ), and nitrogen oxides (NOx) were estimated using the previously developed land use regression models. Results: Prevalent MS cases had a clustered pattern in Tehran. A significant difference in exposure to PM 10 , SO 2 , NO 2 , and NOx (p < 0.001) was observed in MS cases compared with controls. Conclusion: This study revealed the potential role of long-term exposure to air pollutants as an environmental risk factor in MS.</description><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Cluster Analysis</subject><subject>Environmental aspects</subject><subject>Environmental Exposure - adverse effects</subject><subject>Geographic Mapping</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Iran</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - etiology</subject><subject>Original Paper</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Statistics</subject><issn>0251-5350</issn><issn>1423-0208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0c1LwzAUAPAgis6Pg3eRgCAKVl-SJk2PY_gxUBTUc0mzZKtmzUzag_-9kc4dhPBy-b3kfSB0TOCaEF7eAAATknO2hUYkpywDCnIbjYByknHGYQ_tx_gBkLAsd9Ee5RxIAXKE7l98Z9quUQ5PlyulO-wtHjcBv3jn-q7xLU7nqXdds3IGv2pngo9NxE2L38wiqPYKT1M8RDtWuWiO1vcBer-7fZs8ZI_P99PJ-DHTOUCX0VLV1giQOcjaWA3C8qJQeiYFl7ki0ho1K2zCtiRC87KmREqmZ4qBqvOCHaCL4d1V8F-9iV21bKI2zqnW-D5WRHDKZGq5TPTsH_3wfWhTdUnlkpWCEZnU-aDmyplqYZTrFtEPrcdqLFjBiKAUErwcoE4DiMHYahWapQrfFYHqdw3VZg3Jnq6_7uulmW3k39wTOBnApwpzEzZgnf8D-eiIRg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Heydarpour, Pouria</creator><creator>Amini, Hassan</creator><creator>Khoshkish, Shayan</creator><creator>Seidkhani, Hossein</creator><creator>Sahraian, Mohammad Ali</creator><creator>Yunesian, Masud</creator><general>S. 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Amini, Hassan ; Khoshkish, Shayan ; Seidkhani, Hossein ; Sahraian, Mohammad Ali ; Yunesian, Masud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-29abfe608408befc06f577acd86584a18fead7fc40f916c59b21883cda30ab473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Cluster Analysis</topic><topic>Environmental aspects</topic><topic>Environmental Exposure - adverse effects</topic><topic>Geographic Mapping</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Iran</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Multiple Sclerosis - etiology</topic><topic>Original Paper</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Statistics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heydarpour, Pouria</creatorcontrib><creatorcontrib>Amini, Hassan</creatorcontrib><creatorcontrib>Khoshkish, Shayan</creatorcontrib><creatorcontrib>Seidkhani, Hossein</creatorcontrib><creatorcontrib>Sahraian, Mohammad Ali</creatorcontrib><creatorcontrib>Yunesian, Masud</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroepidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heydarpour, Pouria</au><au>Amini, Hassan</au><au>Khoshkish, Shayan</au><au>Seidkhani, Hossein</au><au>Sahraian, Mohammad Ali</au><au>Yunesian, Masud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Impact of Air Pollution on Multiple Sclerosis in Tehran, Iran</atitle><jtitle>Neuroepidemiology</jtitle><addtitle>Neuroepidemiology</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>43</volume><issue>3-4</issue><spage>233</spage><epage>238</epage><pages>233-238</pages><issn>0251-5350</issn><eissn>1423-0208</eissn><abstract>Background: Multiple sclerosis (MS) incidence has dramatically increased in Tehran, Iran. The health impact of air pollution in Tehran underscores the attention to a possible association to this environmental risk factor. In this study, the authors aimed to analyze the spatial distribution of prevalent MS cases and their association with the spatial patterns of air pollution. Methods: Patient records meeting McDonald's criteria for definite MS diagnosis with disease onset during 2003-2013 were obtained. Next, the location of 2,188 patients was successfully geo-referenced within Tehran metropolis by geographic information system (GIS) bureau of Iran's post office based on their phone numbers. A cluster analysis was performed using the average nearest neighbor index (ANNI) and quadrat analysis. The long-term exposures of MS patients to particulate matter (PM 10 ), sulfur dioxide (SO 2 ), nitrogen oxide (NO), nitrogen dioxide (NO 2 ), and nitrogen oxides (NOx) were estimated using the previously developed land use regression models. Results: Prevalent MS cases had a clustered pattern in Tehran. A significant difference in exposure to PM 10 , SO 2 , NO 2 , and NOx (p < 0.001) was observed in MS cases compared with controls. Conclusion: This study revealed the potential role of long-term exposure to air pollutants as an environmental risk factor in MS.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25501708</pmid><doi>10.1159/000368553</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5644-7555</orcidid><orcidid>https://orcid.org/0000-0002-2870-7433</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroepidemiology, 2014-01, Vol.43 (3-4), p.233-238 |
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| source | MEDLINE; Karger Journals |
| subjects | Air pollution Air Pollution - adverse effects Cluster Analysis Environmental aspects Environmental Exposure - adverse effects Geographic Mapping Health aspects Humans Iran Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - etiology Original Paper Prevalence Risk Factors Statistics |
| title | Potential Impact of Air Pollution on Multiple Sclerosis in Tehran, Iran |
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