The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility

Protein solubility is often an essential requirement in biotechnological and biomedical applications. Great advances in understanding the principles that determine this specific property of proteins have been made during the past decade, in particular concerning the physicochemical characteristics o...

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Veröffentlicht in:	Journal of molecular biology 2015-01, Vol.427 (2), p.478-490
Hauptverfasser:	Sormanni, Pietro, Aprile, Francesco A., Vendruscolo, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Chemical Phenomena Circular Dichroism Cloning, Molecular Computer Simulation Escherichia coli - genetics Models, Molecular Molecular Structure Mutant Proteins - chemistry Mutant Proteins - genetics protein aggregation Protein Conformation Protein Engineering - methods protein solubility Recombinant Proteins - chemistry Recombinant Proteins - genetics Solubility
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