Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2

Recent evidence supports the influence of neuroimmune system activation on behavior. We have demonstrated that ethanol activates the innate immune system by stimulating toll-like receptor 4 (TLR4) signaling in glial cells, which triggers the release of inflammatory mediators and causes neuroinflamma...

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Veröffentlicht in:	Neuropharmacology 2015-02, Vol.89, p.352-359
Hauptverfasser:	Pascual, María, Baliño, Pablo, Aragón, Carlos M.G., Guerri, Consuelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Ocular - drug effects Adaptation, Ocular - genetics Animals Anxiety Anxiety - chemically induced Anxiety - metabolism Biomarkers - metabolism Central Nervous System Depressants - adverse effects Cytokines Cytokines - metabolism Disease Models, Animal Encephalitis - chemically induced Encephalitis - metabolism Ethanol Ethanol - adverse effects Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Male Maze Learning - drug effects Mice, Inbred C57BL Mice, Knockout Neuroinflammation TLR4 Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Withdrawal
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