Threshold levels of 25-hydroxyvitamin D and parathyroid hormone for impaired bone health in children with congenital ichthyosis and type IV and V skin
Summary Background Patients with congenital ichthyosis, especially those with darker skin types, are at increased risk of developing vitamin D deficiency and rickets. The relationships between 25‐hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and bone health have not been studied previously,...
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| Veröffentlicht in: | British journal of dermatology (1951) 2015-01, Vol.172 (1), p.208-214 |
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| container_title | British journal of dermatology (1951) |
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| creator | Sethuraman, G. Sreenivas, V. Yenamandra, V.K. Gupta, N. Sharma, V.K. Marwaha, R.K. Bhari, N. Irshad, M. Kabra, M. Thulkar, S. |
| description | Summary
Background
Patients with congenital ichthyosis, especially those with darker skin types, are at increased risk of developing vitamin D deficiency and rickets. The relationships between 25‐hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and bone health have not been studied previously, in ichthyosis.
Objectives
To determine the threshold levels of 25(OH)D and PTH for impaired bone health in children with congenital ichthyosis.
Methods
In this cross‐sectional study, 119 children with ichthyosis and 168 controls were recruited. Serum 25(OH)D, PTH, calcium, phosphate and alkaline phosphatase (ALP) were measured. Radiological screening for rickets was carried out only in children with ichthyosis.
Results
Forty‐seven children with ichthyosis had either clinical or radiological evidence of rickets. The correlation between serum 25(OH)D and PTH showed that a serum level of 25(OH)D 8 ng mL−1 was associated with a significant increase in PTH. The correlation between PTH and ALP showed that a serum PTH level of 75 pg mL−1 was associated with a significant increase in ALP levels. Of the different clinical phenotypes of ichthyosis, both autosomal recessive congenital ichthyosis (ARCI) and epidermolytic ichthyosis (EI) were found to have significantly increased PTH, ALP and radiological rickets scores compared with common ichthyosis.
Conclusions
Serum levels of 25(OH)D ≤ 8 ng mL−1 and PTH ≥ 75 pg mL−1 significantly increases the risk for development of rickets [odds ratio (OR) 2·8; 95% confidence interval (CI) 1·05–7·40; P = 0·04] in ichthyosis. Among the different types, patients with ARCI (OR 4·83; 95% CI 1·74–13·45; P |
| doi_str_mv | 10.1111/bjd.13131 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652376464</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652376464</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3631-13fdf5da87c04446abbfd3de1f8bb8e51adde36098b305895876d2e899087a0d3</originalsourceid><addsrcrecordid>eNp1kV9P3SAYh8myZR6dF_sCC5fzogqlBXo5dZ65uC3GP0t2Q2h5u6K0dNCj9ovs8w7PUe8GF5A3z-9J4IfQe0r2aVoH9Y3ZpyztV2hBGS-znDL2Gi0IISIjFWdbaDvGG0IoIyV5i7byQvKC5GKB_l52AWLnncEO7sBF7Fucl1k3m-Af5js76d4O-BjrweBRBz11c_DW4M6H3g-AWx-w7UdtAxhcP0460G7qcEo1nXUmwIDvbRo0fvgNQxI6bJsueXy0ce2d5hHw6fX6fo3jrR3eoTetdhF2n84ddHXy-fLoS3b2Y3l69OksaxhnNKOsNW1ptBQNKYqC67puDTNAW1nXEkqqjQHGSSXr9HJZlVJwk4OsKiKFJobtoI8b7xj8nxXESfU2NuCcHsCvoqK8zJngBS8SurdBm-BjDNCqMdheh1lRoh5rUKkGta4hsR-etKu6B_NCPv97Ag42wL11MP_fpA6_Hj8rs03CxgkeXhI63CoumCjVz-9LdUi-nV9w8Ust2T8t_6J-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652376464</pqid></control><display><type>article</type><title>Threshold levels of 25-hydroxyvitamin D and parathyroid hormone for impaired bone health in children with congenital ichthyosis and type IV and V skin</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Sethuraman, G. ; Sreenivas, V. ; Yenamandra, V.K. ; Gupta, N. ; Sharma, V.K. ; Marwaha, R.K. ; Bhari, N. ; Irshad, M. ; Kabra, M. ; Thulkar, S.</creator><creatorcontrib>Sethuraman, G. ; Sreenivas, V. ; Yenamandra, V.K. ; Gupta, N. ; Sharma, V.K. ; Marwaha, R.K. ; Bhari, N. ; Irshad, M. ; Kabra, M. ; Thulkar, S.</creatorcontrib><description>Summary
Background
Patients with congenital ichthyosis, especially those with darker skin types, are at increased risk of developing vitamin D deficiency and rickets. The relationships between 25‐hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and bone health have not been studied previously, in ichthyosis.
Objectives
To determine the threshold levels of 25(OH)D and PTH for impaired bone health in children with congenital ichthyosis.
Methods
In this cross‐sectional study, 119 children with ichthyosis and 168 controls were recruited. Serum 25(OH)D, PTH, calcium, phosphate and alkaline phosphatase (ALP) were measured. Radiological screening for rickets was carried out only in children with ichthyosis.
Results
Forty‐seven children with ichthyosis had either clinical or radiological evidence of rickets. The correlation between serum 25(OH)D and PTH showed that a serum level of 25(OH)D 8 ng mL−1 was associated with a significant increase in PTH. The correlation between PTH and ALP showed that a serum PTH level of 75 pg mL−1 was associated with a significant increase in ALP levels. Of the different clinical phenotypes of ichthyosis, both autosomal recessive congenital ichthyosis (ARCI) and epidermolytic ichthyosis (EI) were found to have significantly increased PTH, ALP and radiological rickets scores compared with common ichthyosis.
Conclusions
Serum levels of 25(OH)D ≤ 8 ng mL−1 and PTH ≥ 75 pg mL−1 significantly increases the risk for development of rickets [odds ratio (OR) 2·8; 95% confidence interval (CI) 1·05–7·40; P = 0·04] in ichthyosis. Among the different types, patients with ARCI (OR 4·83; 95% CI 1·74–13·45; P < 0·01) and EI (OR 5·71; 95% CI 1·74–18·79; P < 0·01) are at an increased risk of developing rickets.
What's already known about this topic?
Children with congenital ichthyosis, especially those with darker skin types, are at an increased risk of developing vitamin D deficiency and rickets.
The threshold levels of vitamin D and parathyroid hormone for adverse bone health have not been studied previously in patients with ichthyosis.
What does this study add?
Children with congenital ichthyosis having serum levels of 25(OH)D ≤ 8 ng mL−1 and PTH ≥ 75 pg mL−1 are more prone to developing rickets and, in particular, those with autosomal recessive congenital ichthyosis and epidermolytic ichthyosis.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/bjd.13131</identifier><identifier>PMID: 24864027</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Hyperparathyroidism - blood ; Hyperparathyroidism - complications ; Ichthyosis, Lamellar - blood ; Ichthyosis, Lamellar - complications ; Infant ; Male ; Parathyroid Hormone - metabolism ; Rickets - blood ; Rickets - etiology ; Vitamin D - analogs & derivatives ; Vitamin D - metabolism ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications</subject><ispartof>British journal of dermatology (1951), 2015-01, Vol.172 (1), p.208-214</ispartof><rights>2014 British Association of Dermatologists</rights><rights>2014 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3631-13fdf5da87c04446abbfd3de1f8bb8e51adde36098b305895876d2e899087a0d3</citedby><cites>FETCH-LOGICAL-c3631-13fdf5da87c04446abbfd3de1f8bb8e51adde36098b305895876d2e899087a0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjd.13131$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjd.13131$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24864027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sethuraman, G.</creatorcontrib><creatorcontrib>Sreenivas, V.</creatorcontrib><creatorcontrib>Yenamandra, V.K.</creatorcontrib><creatorcontrib>Gupta, N.</creatorcontrib><creatorcontrib>Sharma, V.K.</creatorcontrib><creatorcontrib>Marwaha, R.K.</creatorcontrib><creatorcontrib>Bhari, N.</creatorcontrib><creatorcontrib>Irshad, M.</creatorcontrib><creatorcontrib>Kabra, M.</creatorcontrib><creatorcontrib>Thulkar, S.</creatorcontrib><title>Threshold levels of 25-hydroxyvitamin D and parathyroid hormone for impaired bone health in children with congenital ichthyosis and type IV and V skin</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background
Patients with congenital ichthyosis, especially those with darker skin types, are at increased risk of developing vitamin D deficiency and rickets. The relationships between 25‐hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and bone health have not been studied previously, in ichthyosis.
Objectives
To determine the threshold levels of 25(OH)D and PTH for impaired bone health in children with congenital ichthyosis.
Methods
In this cross‐sectional study, 119 children with ichthyosis and 168 controls were recruited. Serum 25(OH)D, PTH, calcium, phosphate and alkaline phosphatase (ALP) were measured. Radiological screening for rickets was carried out only in children with ichthyosis.
Results
Forty‐seven children with ichthyosis had either clinical or radiological evidence of rickets. The correlation between serum 25(OH)D and PTH showed that a serum level of 25(OH)D 8 ng mL−1 was associated with a significant increase in PTH. The correlation between PTH and ALP showed that a serum PTH level of 75 pg mL−1 was associated with a significant increase in ALP levels. Of the different clinical phenotypes of ichthyosis, both autosomal recessive congenital ichthyosis (ARCI) and epidermolytic ichthyosis (EI) were found to have significantly increased PTH, ALP and radiological rickets scores compared with common ichthyosis.
Conclusions
Serum levels of 25(OH)D ≤ 8 ng mL−1 and PTH ≥ 75 pg mL−1 significantly increases the risk for development of rickets [odds ratio (OR) 2·8; 95% confidence interval (CI) 1·05–7·40; P = 0·04] in ichthyosis. Among the different types, patients with ARCI (OR 4·83; 95% CI 1·74–13·45; P < 0·01) and EI (OR 5·71; 95% CI 1·74–18·79; P < 0·01) are at an increased risk of developing rickets.
What's already known about this topic?
Children with congenital ichthyosis, especially those with darker skin types, are at an increased risk of developing vitamin D deficiency and rickets.
The threshold levels of vitamin D and parathyroid hormone for adverse bone health have not been studied previously in patients with ichthyosis.
What does this study add?
Children with congenital ichthyosis having serum levels of 25(OH)D ≤ 8 ng mL−1 and PTH ≥ 75 pg mL−1 are more prone to developing rickets and, in particular, those with autosomal recessive congenital ichthyosis and epidermolytic ichthyosis.</description><subject>Adolescent</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperparathyroidism - blood</subject><subject>Hyperparathyroidism - complications</subject><subject>Ichthyosis, Lamellar - blood</subject><subject>Ichthyosis, Lamellar - complications</subject><subject>Infant</subject><subject>Male</subject><subject>Parathyroid Hormone - metabolism</subject><subject>Rickets - blood</subject><subject>Rickets - etiology</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - metabolism</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9P3SAYh8myZR6dF_sCC5fzogqlBXo5dZ65uC3GP0t2Q2h5u6K0dNCj9ovs8w7PUe8GF5A3z-9J4IfQe0r2aVoH9Y3ZpyztV2hBGS-znDL2Gi0IISIjFWdbaDvGG0IoIyV5i7byQvKC5GKB_l52AWLnncEO7sBF7Fucl1k3m-Af5js76d4O-BjrweBRBz11c_DW4M6H3g-AWx-w7UdtAxhcP0460G7qcEo1nXUmwIDvbRo0fvgNQxI6bJsueXy0ce2d5hHw6fX6fo3jrR3eoTetdhF2n84ddHXy-fLoS3b2Y3l69OksaxhnNKOsNW1ptBQNKYqC67puDTNAW1nXEkqqjQHGSSXr9HJZlVJwk4OsKiKFJobtoI8b7xj8nxXESfU2NuCcHsCvoqK8zJngBS8SurdBm-BjDNCqMdheh1lRoh5rUKkGta4hsR-etKu6B_NCPv97Ag42wL11MP_fpA6_Hj8rs03CxgkeXhI63CoumCjVz-9LdUi-nV9w8Ust2T8t_6J-</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Sethuraman, G.</creator><creator>Sreenivas, V.</creator><creator>Yenamandra, V.K.</creator><creator>Gupta, N.</creator><creator>Sharma, V.K.</creator><creator>Marwaha, R.K.</creator><creator>Bhari, N.</creator><creator>Irshad, M.</creator><creator>Kabra, M.</creator><creator>Thulkar, S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>Threshold levels of 25-hydroxyvitamin D and parathyroid hormone for impaired bone health in children with congenital ichthyosis and type IV and V skin</title><author>Sethuraman, G. ; Sreenivas, V. ; Yenamandra, V.K. ; Gupta, N. ; Sharma, V.K. ; Marwaha, R.K. ; Bhari, N. ; Irshad, M. ; Kabra, M. ; Thulkar, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3631-13fdf5da87c04446abbfd3de1f8bb8e51adde36098b305895876d2e899087a0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperparathyroidism - blood</topic><topic>Hyperparathyroidism - complications</topic><topic>Ichthyosis, Lamellar - blood</topic><topic>Ichthyosis, Lamellar - complications</topic><topic>Infant</topic><topic>Male</topic><topic>Parathyroid Hormone - metabolism</topic><topic>Rickets - blood</topic><topic>Rickets - etiology</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - metabolism</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sethuraman, G.</creatorcontrib><creatorcontrib>Sreenivas, V.</creatorcontrib><creatorcontrib>Yenamandra, V.K.</creatorcontrib><creatorcontrib>Gupta, N.</creatorcontrib><creatorcontrib>Sharma, V.K.</creatorcontrib><creatorcontrib>Marwaha, R.K.</creatorcontrib><creatorcontrib>Bhari, N.</creatorcontrib><creatorcontrib>Irshad, M.</creatorcontrib><creatorcontrib>Kabra, M.</creatorcontrib><creatorcontrib>Thulkar, S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sethuraman, G.</au><au>Sreenivas, V.</au><au>Yenamandra, V.K.</au><au>Gupta, N.</au><au>Sharma, V.K.</au><au>Marwaha, R.K.</au><au>Bhari, N.</au><au>Irshad, M.</au><au>Kabra, M.</au><au>Thulkar, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Threshold levels of 25-hydroxyvitamin D and parathyroid hormone for impaired bone health in children with congenital ichthyosis and type IV and V skin</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2015-01</date><risdate>2015</risdate><volume>172</volume><issue>1</issue><spage>208</spage><epage>214</epage><pages>208-214</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>Summary
Background
Patients with congenital ichthyosis, especially those with darker skin types, are at increased risk of developing vitamin D deficiency and rickets. The relationships between 25‐hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and bone health have not been studied previously, in ichthyosis.
Objectives
To determine the threshold levels of 25(OH)D and PTH for impaired bone health in children with congenital ichthyosis.
Methods
In this cross‐sectional study, 119 children with ichthyosis and 168 controls were recruited. Serum 25(OH)D, PTH, calcium, phosphate and alkaline phosphatase (ALP) were measured. Radiological screening for rickets was carried out only in children with ichthyosis.
Results
Forty‐seven children with ichthyosis had either clinical or radiological evidence of rickets. The correlation between serum 25(OH)D and PTH showed that a serum level of 25(OH)D 8 ng mL−1 was associated with a significant increase in PTH. The correlation between PTH and ALP showed that a serum PTH level of 75 pg mL−1 was associated with a significant increase in ALP levels. Of the different clinical phenotypes of ichthyosis, both autosomal recessive congenital ichthyosis (ARCI) and epidermolytic ichthyosis (EI) were found to have significantly increased PTH, ALP and radiological rickets scores compared with common ichthyosis.
Conclusions
Serum levels of 25(OH)D ≤ 8 ng mL−1 and PTH ≥ 75 pg mL−1 significantly increases the risk for development of rickets [odds ratio (OR) 2·8; 95% confidence interval (CI) 1·05–7·40; P = 0·04] in ichthyosis. Among the different types, patients with ARCI (OR 4·83; 95% CI 1·74–13·45; P < 0·01) and EI (OR 5·71; 95% CI 1·74–18·79; P < 0·01) are at an increased risk of developing rickets.
What's already known about this topic?
Children with congenital ichthyosis, especially those with darker skin types, are at an increased risk of developing vitamin D deficiency and rickets.
The threshold levels of vitamin D and parathyroid hormone for adverse bone health have not been studied previously in patients with ichthyosis.
What does this study add?
Children with congenital ichthyosis having serum levels of 25(OH)D ≤ 8 ng mL−1 and PTH ≥ 75 pg mL−1 are more prone to developing rickets and, in particular, those with autosomal recessive congenital ichthyosis and epidermolytic ichthyosis.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24864027</pmid><doi>10.1111/bjd.13131</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 2015-01, Vol.172 (1), p.208-214 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1652376464 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Case-Control Studies Child Child, Preschool Cross-Sectional Studies Female Humans Hyperparathyroidism - blood Hyperparathyroidism - complications Ichthyosis, Lamellar - blood Ichthyosis, Lamellar - complications Infant Male Parathyroid Hormone - metabolism Rickets - blood Rickets - etiology Vitamin D - analogs & derivatives Vitamin D - metabolism Vitamin D Deficiency - blood Vitamin D Deficiency - complications |
| title | Threshold levels of 25-hydroxyvitamin D and parathyroid hormone for impaired bone health in children with congenital ichthyosis and type IV and V skin |
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