Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress
Depression is a common psychiatric disorder associated with chronic stress. Insulin-like growth factor 2 (IGF2) is a growth factor that serves important roles in the brain during development and at adulthood. Here, the role of IGF2 expression in the hippocampus was investigated in a rat model of dep...
Gespeichert in:
| Veröffentlicht in: | Neuropharmacology 2015-02, Vol.89, p.318-324 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 324 |
|---|---|
| container_issue | |
| container_start_page | 318 |
| container_title | Neuropharmacology |
| container_volume | 89 |
| creator | Luo, Yan-Wei Xu, Yang Cao, Wen-Yu Zhong, Xiao-Lin Duan, Juan Wang, Xue-Qin Hu, Zhao-Lan Li, Fang Zhang, Jian-Yi Zhou, Ming Dai, Ru-Ping Li, Chang-Qi |
| description | Depression is a common psychiatric disorder associated with chronic stress. Insulin-like growth factor 2 (IGF2) is a growth factor that serves important roles in the brain during development and at adulthood. Here, the role of IGF2 expression in the hippocampus was investigated in a rat model of depression. A chronic restraint stress (CRS) model of depression was established in rats, exhibiting depression-like behavior as assessed with the sucrose preference test (SPT) and forced swimming test (FST), and with evaluation of the corticosterone levels. Hippocampal IGF2 levels were significantly lower in rats suffering CRS than in controls, as were levels of pERK1/2 and GluR1. Lentivirus-mediated hippocampal IGF2 overexpression alleviated depressive behavior in restrained rats, elevated the levels of pERK1/2 and GluR1 proteins, but it did not affect the expression of pGSK3β, GluR2, NMDAR1, and NMDAR2A. These results suggest the chronic restraint stress induces depressive behavior, which may be mediated by ERK-dependent IGF2 signaling, pointing to an antidepressant role for this molecular pathway.
•Chronic restraint stress was associated with decreased IGF2 expression in the hippocampus.•Induced IGF2 expression alleviated depressive-like behaviors in stressed rats.•Induced IGF2 expression prevented GluR1 down-regulation in stressed rats.•The antidepressant effect of IGF2 was mediated by ERK signaling. |
| doi_str_mv | 10.1016/j.neuropharm.2014.10.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652375885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S002839081400375X</els_id><sourcerecordid>1647020245</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-7736f555a872818a6b758e808d26b623551470938b7681802fba52062c8db7f43</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EotuPv4B85JJl7PirR6j4qFSJS3viYDnOpOsliRfb2Yp_j6MtcITTSPM-M-9oXkIogy0Dpt7ttzMuKR52Lk1bDkzU9hYYe0E2zOi20aDES7IB4KZpr8GckfOc9wAgDDOvyRmXQiil5YZ8u53zMoa5GcN3pI8pPpUdHZwvMVFOp1DCoyuYaY-HhDmHI9IOd-4Yqh5m6mhyhU6xx5HGgfpdinPwNJcVviSvBjdmvHquF-Th08f7my_N3dfPtzfv7xovdFsarVs1SCmd0bye51SnpUEDpueqU7yVkgkN163ptKo68KFzkoPi3vSdHkR7Qd6e9h5S_LFgLnYK2eM4uhnjki1Tkrd1p5H_gVYrDlysqDmhPsWcEw72kMLk0k_LwK4p2L39m4JdU1iVmkIdffPssnQT9n8Gf7-9Ah9OANa3HAMmm33A2WMfEvpi-xj-7fILftScjg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1647020245</pqid></control><display><type>article</type><title>Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Luo, Yan-Wei ; Xu, Yang ; Cao, Wen-Yu ; Zhong, Xiao-Lin ; Duan, Juan ; Wang, Xue-Qin ; Hu, Zhao-Lan ; Li, Fang ; Zhang, Jian-Yi ; Zhou, Ming ; Dai, Ru-Ping ; Li, Chang-Qi</creator><creatorcontrib>Luo, Yan-Wei ; Xu, Yang ; Cao, Wen-Yu ; Zhong, Xiao-Lin ; Duan, Juan ; Wang, Xue-Qin ; Hu, Zhao-Lan ; Li, Fang ; Zhang, Jian-Yi ; Zhou, Ming ; Dai, Ru-Ping ; Li, Chang-Qi</creatorcontrib><description>Depression is a common psychiatric disorder associated with chronic stress. Insulin-like growth factor 2 (IGF2) is a growth factor that serves important roles in the brain during development and at adulthood. Here, the role of IGF2 expression in the hippocampus was investigated in a rat model of depression. A chronic restraint stress (CRS) model of depression was established in rats, exhibiting depression-like behavior as assessed with the sucrose preference test (SPT) and forced swimming test (FST), and with evaluation of the corticosterone levels. Hippocampal IGF2 levels were significantly lower in rats suffering CRS than in controls, as were levels of pERK1/2 and GluR1. Lentivirus-mediated hippocampal IGF2 overexpression alleviated depressive behavior in restrained rats, elevated the levels of pERK1/2 and GluR1 proteins, but it did not affect the expression of pGSK3β, GluR2, NMDAR1, and NMDAR2A. These results suggest the chronic restraint stress induces depressive behavior, which may be mediated by ERK-dependent IGF2 signaling, pointing to an antidepressant role for this molecular pathway.
•Chronic restraint stress was associated with decreased IGF2 expression in the hippocampus.•Induced IGF2 expression alleviated depressive-like behaviors in stressed rats.•Induced IGF2 expression prevented GluR1 down-regulation in stressed rats.•The antidepressant effect of IGF2 was mediated by ERK signaling.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/j.neuropharm.2014.10.011</identifier><identifier>PMID: 25446675</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antidepressant ; Body Weight - physiology ; Chronic Disease ; Corticosterone - metabolism ; Depression ; Depression - drug therapy ; Depression - etiology ; Disease Models, Animal ; ERK1/2 ; Food Preferences ; Gene Expression Regulation - physiology ; Glycogen Synthase Kinase 3 - metabolism ; Glycogen Synthase Kinase 3 beta ; Green Fluorescent Proteins - genetics ; Green Fluorescent Proteins - metabolism ; Hippocampus ; IGF2 ; Insulin-Like Growth Factor II - genetics ; Insulin-Like Growth Factor II - metabolism ; Male ; MAP Kinase Signaling System - physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA - genetics ; Receptors, AMPA - metabolism ; Stress, Psychological - complications ; Stress, Psychological - pathology ; Sucrose - administration & dosage ; Swimming - psychology ; Transduction, Genetic</subject><ispartof>Neuropharmacology, 2015-02, Vol.89, p.318-324</ispartof><rights>2014 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-7736f555a872818a6b758e808d26b623551470938b7681802fba52062c8db7f43</citedby><cites>FETCH-LOGICAL-c473t-7736f555a872818a6b758e808d26b623551470938b7681802fba52062c8db7f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S002839081400375X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25446675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Yan-Wei</creatorcontrib><creatorcontrib>Xu, Yang</creatorcontrib><creatorcontrib>Cao, Wen-Yu</creatorcontrib><creatorcontrib>Zhong, Xiao-Lin</creatorcontrib><creatorcontrib>Duan, Juan</creatorcontrib><creatorcontrib>Wang, Xue-Qin</creatorcontrib><creatorcontrib>Hu, Zhao-Lan</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Zhang, Jian-Yi</creatorcontrib><creatorcontrib>Zhou, Ming</creatorcontrib><creatorcontrib>Dai, Ru-Ping</creatorcontrib><creatorcontrib>Li, Chang-Qi</creatorcontrib><title>Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Depression is a common psychiatric disorder associated with chronic stress. Insulin-like growth factor 2 (IGF2) is a growth factor that serves important roles in the brain during development and at adulthood. Here, the role of IGF2 expression in the hippocampus was investigated in a rat model of depression. A chronic restraint stress (CRS) model of depression was established in rats, exhibiting depression-like behavior as assessed with the sucrose preference test (SPT) and forced swimming test (FST), and with evaluation of the corticosterone levels. Hippocampal IGF2 levels were significantly lower in rats suffering CRS than in controls, as were levels of pERK1/2 and GluR1. Lentivirus-mediated hippocampal IGF2 overexpression alleviated depressive behavior in restrained rats, elevated the levels of pERK1/2 and GluR1 proteins, but it did not affect the expression of pGSK3β, GluR2, NMDAR1, and NMDAR2A. These results suggest the chronic restraint stress induces depressive behavior, which may be mediated by ERK-dependent IGF2 signaling, pointing to an antidepressant role for this molecular pathway.
•Chronic restraint stress was associated with decreased IGF2 expression in the hippocampus.•Induced IGF2 expression alleviated depressive-like behaviors in stressed rats.•Induced IGF2 expression prevented GluR1 down-regulation in stressed rats.•The antidepressant effect of IGF2 was mediated by ERK signaling.</description><subject>Animals</subject><subject>Antidepressant</subject><subject>Body Weight - physiology</subject><subject>Chronic Disease</subject><subject>Corticosterone - metabolism</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Depression - etiology</subject><subject>Disease Models, Animal</subject><subject>ERK1/2</subject><subject>Food Preferences</subject><subject>Gene Expression Regulation - physiology</subject><subject>Glycogen Synthase Kinase 3 - metabolism</subject><subject>Glycogen Synthase Kinase 3 beta</subject><subject>Green Fluorescent Proteins - genetics</subject><subject>Green Fluorescent Proteins - metabolism</subject><subject>Hippocampus</subject><subject>IGF2</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Insulin-Like Growth Factor II - metabolism</subject><subject>Male</subject><subject>MAP Kinase Signaling System - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, AMPA - genetics</subject><subject>Receptors, AMPA - metabolism</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - pathology</subject><subject>Sucrose - administration & dosage</subject><subject>Swimming - psychology</subject><subject>Transduction, Genetic</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotuPv4B85JJl7PirR6j4qFSJS3viYDnOpOsliRfb2Yp_j6MtcITTSPM-M-9oXkIogy0Dpt7ttzMuKR52Lk1bDkzU9hYYe0E2zOi20aDES7IB4KZpr8GckfOc9wAgDDOvyRmXQiil5YZ8u53zMoa5GcN3pI8pPpUdHZwvMVFOp1DCoyuYaY-HhDmHI9IOd-4Yqh5m6mhyhU6xx5HGgfpdinPwNJcVviSvBjdmvHquF-Th08f7my_N3dfPtzfv7xovdFsarVs1SCmd0bye51SnpUEDpueqU7yVkgkN163ptKo68KFzkoPi3vSdHkR7Qd6e9h5S_LFgLnYK2eM4uhnjki1Tkrd1p5H_gVYrDlysqDmhPsWcEw72kMLk0k_LwK4p2L39m4JdU1iVmkIdffPssnQT9n8Gf7-9Ah9OANa3HAMmm33A2WMfEvpi-xj-7fILftScjg</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Luo, Yan-Wei</creator><creator>Xu, Yang</creator><creator>Cao, Wen-Yu</creator><creator>Zhong, Xiao-Lin</creator><creator>Duan, Juan</creator><creator>Wang, Xue-Qin</creator><creator>Hu, Zhao-Lan</creator><creator>Li, Fang</creator><creator>Zhang, Jian-Yi</creator><creator>Zhou, Ming</creator><creator>Dai, Ru-Ping</creator><creator>Li, Chang-Qi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress</title><author>Luo, Yan-Wei ; Xu, Yang ; Cao, Wen-Yu ; Zhong, Xiao-Lin ; Duan, Juan ; Wang, Xue-Qin ; Hu, Zhao-Lan ; Li, Fang ; Zhang, Jian-Yi ; Zhou, Ming ; Dai, Ru-Ping ; Li, Chang-Qi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-7736f555a872818a6b758e808d26b623551470938b7681802fba52062c8db7f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antidepressant</topic><topic>Body Weight - physiology</topic><topic>Chronic Disease</topic><topic>Corticosterone - metabolism</topic><topic>Depression</topic><topic>Depression - drug therapy</topic><topic>Depression - etiology</topic><topic>Disease Models, Animal</topic><topic>ERK1/2</topic><topic>Food Preferences</topic><topic>Gene Expression Regulation - physiology</topic><topic>Glycogen Synthase Kinase 3 - metabolism</topic><topic>Glycogen Synthase Kinase 3 beta</topic><topic>Green Fluorescent Proteins - genetics</topic><topic>Green Fluorescent Proteins - metabolism</topic><topic>Hippocampus</topic><topic>IGF2</topic><topic>Insulin-Like Growth Factor II - genetics</topic><topic>Insulin-Like Growth Factor II - metabolism</topic><topic>Male</topic><topic>MAP Kinase Signaling System - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, AMPA - genetics</topic><topic>Receptors, AMPA - metabolism</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - pathology</topic><topic>Sucrose - administration & dosage</topic><topic>Swimming - psychology</topic><topic>Transduction, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Yan-Wei</creatorcontrib><creatorcontrib>Xu, Yang</creatorcontrib><creatorcontrib>Cao, Wen-Yu</creatorcontrib><creatorcontrib>Zhong, Xiao-Lin</creatorcontrib><creatorcontrib>Duan, Juan</creatorcontrib><creatorcontrib>Wang, Xue-Qin</creatorcontrib><creatorcontrib>Hu, Zhao-Lan</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Zhang, Jian-Yi</creatorcontrib><creatorcontrib>Zhou, Ming</creatorcontrib><creatorcontrib>Dai, Ru-Ping</creatorcontrib><creatorcontrib>Li, Chang-Qi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Yan-Wei</au><au>Xu, Yang</au><au>Cao, Wen-Yu</au><au>Zhong, Xiao-Lin</au><au>Duan, Juan</au><au>Wang, Xue-Qin</au><au>Hu, Zhao-Lan</au><au>Li, Fang</au><au>Zhang, Jian-Yi</au><au>Zhou, Ming</au><au>Dai, Ru-Ping</au><au>Li, Chang-Qi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>89</volume><spage>318</spage><epage>324</epage><pages>318-324</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><abstract>Depression is a common psychiatric disorder associated with chronic stress. Insulin-like growth factor 2 (IGF2) is a growth factor that serves important roles in the brain during development and at adulthood. Here, the role of IGF2 expression in the hippocampus was investigated in a rat model of depression. A chronic restraint stress (CRS) model of depression was established in rats, exhibiting depression-like behavior as assessed with the sucrose preference test (SPT) and forced swimming test (FST), and with evaluation of the corticosterone levels. Hippocampal IGF2 levels were significantly lower in rats suffering CRS than in controls, as were levels of pERK1/2 and GluR1. Lentivirus-mediated hippocampal IGF2 overexpression alleviated depressive behavior in restrained rats, elevated the levels of pERK1/2 and GluR1 proteins, but it did not affect the expression of pGSK3β, GluR2, NMDAR1, and NMDAR2A. These results suggest the chronic restraint stress induces depressive behavior, which may be mediated by ERK-dependent IGF2 signaling, pointing to an antidepressant role for this molecular pathway.
•Chronic restraint stress was associated with decreased IGF2 expression in the hippocampus.•Induced IGF2 expression alleviated depressive-like behaviors in stressed rats.•Induced IGF2 expression prevented GluR1 down-regulation in stressed rats.•The antidepressant effect of IGF2 was mediated by ERK signaling.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25446675</pmid><doi>10.1016/j.neuropharm.2014.10.011</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3908 |
| ispartof | Neuropharmacology, 2015-02, Vol.89, p.318-324 |
| issn | 0028-3908 1873-7064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1652375885 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antidepressant Body Weight - physiology Chronic Disease Corticosterone - metabolism Depression Depression - drug therapy Depression - etiology Disease Models, Animal ERK1/2 Food Preferences Gene Expression Regulation - physiology Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hippocampus IGF2 Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Male MAP Kinase Signaling System - physiology Rats Rats, Sprague-Dawley Receptors, AMPA - genetics Receptors, AMPA - metabolism Stress, Psychological - complications Stress, Psychological - pathology Sucrose - administration & dosage Swimming - psychology Transduction, Genetic |
| title | Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T03%3A39%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insulin-like%20growth%20factor%202%20mitigates%20depressive%20behavior%20in%20a%20rat%20model%20of%20chronic%20stress&rft.jtitle=Neuropharmacology&rft.au=Luo,%20Yan-Wei&rft.date=2015-02-01&rft.volume=89&rft.spage=318&rft.epage=324&rft.pages=318-324&rft.issn=0028-3908&rft.eissn=1873-7064&rft_id=info:doi/10.1016/j.neuropharm.2014.10.011&rft_dat=%3Cproquest_cross%3E1647020245%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1647020245&rft_id=info:pmid/25446675&rft_els_id=S002839081400375X&rfr_iscdi=true |