Complex behavior of marine animal tissue extracts in the competitive binding assay of brevetoxins with rat brain synaptosomes

Brevetoxins are produced by the marine dinoflagellate Ptychodiscus brevis, an organism linked to red tide outbreaks, and the accompanying toxicity to marine animals and to neurotoxic shellfish poisoning in humans. Brevetoxins bind with high affinity to voltage‐sensitive sodium channels and cause inc...

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Veröffentlicht in:	Natural toxins 1997, Vol.5 (5), p.193-200
Hauptverfasser:	Whitney, Philip L., Delgado, Jesus A., Baden, Daniel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biological Assay - methods Bivalvia Brain - metabolism brevetoxin assay dinoflagellate Fishes In Vitro Techniques Least-Squares Analysis Liver Extracts - chemistry Liver Extracts - metabolism Mammals Marine Marine Toxins - analysis Marine Toxins - isolation & purification neurotoxin Neurotoxins - analysis Neurotoxins - isolation & purification Oxocins Ptychodiscus brevis Rats red tide Reproducibility of Results Synaptosomes - metabolism Tissue Extracts - chemistry Tissue Extracts - metabolism Turtles voltage-sensitive sodium channels
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