Blockade of behavioral sensitization to cocaine and amphetamine by inhibitors of protein synthesis

Anisomycin and cycloheximide were used to investigate the role of protein synthesis in the mechanism of behavioral sensitization to the stereotypic effects of cocaine and amphetamine in mice. The drugs completely antagonize induction and partially block expression of the sensitization. Because these...

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Veröffentlicht in:	Brain research 1993-02, Vol.603 (1), p.19-24
Hauptverfasser:	Karler, Ralph, Finnegan, Kevin T., Calder, Larry D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine Amphetamine - antagonists & inhibitors Amphetamine - pharmacology Animals Anisomycin Anisomycin - pharmacology Behavior, Animal - drug effects Behavioral sensitization Biological and medical sciences Cocaine Cocaine - antagonists & inhibitors Cocaine - pharmacology Cycloheximide Cycloheximide - pharmacology Injections, Intraperitoneal Male Medical sciences Mice Mouse Neuropharmacology Pharmacology. Drug treatments Protein synthesis inhibitor Protein Synthesis Inhibitors - pharmacology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Seizures - chemically induced Seizures - prevention & control Stereotyped Behavior - drug effects
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