Metabolic modeling of fumaric acid production by Rhizopus arrhizus
A metabolic mode is developed for fumaric acid production by Rhizopus arrhizus . The model describes the reaction network and the extents of reaction in terms of the concentrations of the measurable species. The proposed pathway consists of the Embden-Meyerhof pathway and two pathways to FA producti...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 1991-01, Vol.28, p.471-486 |
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| container_title | Applied biochemistry and biotechnology |
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| creator | Gangl, I.C. (Illinois Institute of Technology, Chicago, IL) Weigand, W.A Keller, F.A |
| description | A metabolic mode is developed for fumaric acid production by Rhizopus arrhizus . The model describes the reaction network and the extents of reaction in terms of the concentrations of the measurable species. The proposed pathway consists of the Embden-Meyerhof pathway and two pathways to FA production, both of which require CO sub(2) fixation (the forward and the reverse TCA cycles). Relationships among the measurable quantities, in addition to those obtainable by a macroscopic mas balance, are found by invoking a pseudo-steady-state assumption on the nonaccumulating species in the pathway. Applications of the metabolic model, such as verifying the proposed pathway, obtaining the theoretical yield and selectivity, and detecting experimental errors, are discussed. |
| doi_str_mv | 10.1007/BF02922626 |
| format | Article |
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| ispartof | Applied biochemistry and biotechnology, 1991-01, Vol.28, p.471-486 |
| issn | 0273-2289 1559-0291 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | ACIDE ORGANIQUE ACIDOS ORGANICOS BIOCHEMICAL PATHWAYS Biological and medical sciences BIOLOGICAL PRODUCTION Biotechnology Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology ORGANIC ACIDS RHIZOPUS Rhizopus arrhizus VIA BIOQUIMICA DEL METABOLISMO VOIE BIOCHIMIQUE DU METABOLISME |
| title | Metabolic modeling of fumaric acid production by Rhizopus arrhizus |
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