Enhancement of anti arthritic effect of quercetin using thioglycolic acid-capped cadmium telluride quantum dots as nanocarrier in adjuvant induced arthritic Wistar rats
•Enhancement of antiarthritic effect of quercetin (QE) using quantum dots (QDs) as nanocarrier.•Quantum dots enhance the efficacy of drug delivery.•QDs-QE complex has brought back the hematological changes in arthritic animals.•Cartilage regeneration in arthritic rats treated with QDs-QE complex was...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2013-12, Vol.112, p.255-263 |
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| creator | Jeyadevi, R. Sivasudha, T. Rameshkumar, A. Ananth, D. Arul Aseervatham, G. Smilin Bell Kumaresan, K. Kumar, L. Dinesh Jagadeeswari, S. Renganathan, R. |
| description | •Enhancement of antiarthritic effect of quercetin (QE) using quantum dots (QDs) as nanocarrier.•Quantum dots enhance the efficacy of drug delivery.•QDs-QE complex has brought back the hematological changes in arthritic animals.•Cartilage regeneration in arthritic rats treated with QDs-QE complex was observed.
In this present study, we investigated thio glycolic acid-capped cadmium telluride quantum dots (TGA-CdTe QDs) as nano carrier to study the antiarthritic activity of quercetin on adjuvant induced arthritic Wistar rats. The free radical scavenging activity of QDs-QE complex was evaluated by 2,2′-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and superoxide anion scavenging assays. Fifteen days after adjuvant induction, arthritic rats received QDs-QE complex orally at the dose of 0.2 and 0.4mg/kg daily for 3 weeks. Diclofenac sodium (DF) was used as a reference drug. Administration of QDs-QE complex showed a significant reduction in inflammation and improvement in cartilage regeneration. Treatment with QDs-QE complex significantly (P |
| doi_str_mv | 10.1016/j.colsurfb.2013.07.065 |
| format | Article |
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In this present study, we investigated thio glycolic acid-capped cadmium telluride quantum dots (TGA-CdTe QDs) as nano carrier to study the antiarthritic activity of quercetin on adjuvant induced arthritic Wistar rats. The free radical scavenging activity of QDs-QE complex was evaluated by 2,2′-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and superoxide anion scavenging assays. Fifteen days after adjuvant induction, arthritic rats received QDs-QE complex orally at the dose of 0.2 and 0.4mg/kg daily for 3 weeks. Diclofenac sodium (DF) was used as a reference drug. Administration of QDs-QE complex showed a significant reduction in inflammation and improvement in cartilage regeneration. Treatment with QDs-QE complex significantly (P<0.05) reduced the expressions lipid peroxidation and showed significant (P<0.05) increase in activities of antioxidant enzymes such as superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) catalase (CAT) levels in paw tissue. C-reactive protein (CRP), rheumatoid factor (RF), red blood cells (RBC) and white blood cells (WBC) count and erythrocyte sedimentation rate (ESR) of experimental animals were also estimated. Histology of hind limb tissue in experimental groups confirmed the complete cartilage regeneration in arthritis induced rats treated with QDs-QE complex. Based on our findings, we suggest that the QDs act as nano carrier for the drugs used in the treatment of various degenerative diseases.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2013.07.065</identifier><identifier>PMID: 23994749</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>2,2-diphenyl-1-picrylhydrazyl ; Adjuvants ; Animals ; Anti arthritic ; antioxidant activity ; Antioxidants - administration & dosage ; arthritis ; Arthritis, Experimental - blood ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - pathology ; C-reactive protein ; Cadmium ; Cadmium Compounds - chemistry ; Carriers ; cartilage ; catalase ; colloids ; Drug Carriers - chemistry ; Drug Delivery Systems ; drugs ; erythrocyte count ; erythrocyte sedimentation rate ; erythrocytes ; Female ; Fluorescence quenching ; free radical scavengers ; Glutathione ; glutathione peroxidase ; histology ; inflammation ; Intermetallics ; laboratory animals ; leukocytes ; lipid peroxidation ; Nanocarrier ; nanocarriers ; Nanostructure ; nitric oxide ; Particle Size ; Quantum dots ; Quantum Dots - chemistry ; Quantum Dots - ultrastructure ; Quercetin ; Quercetin - administration & dosage ; Radiology ; Rats ; Rats, Wistar ; Scavenging ; Spectrophotometry ; superoxide anion ; superoxide dismutase ; Tellurium - chemistry ; Thioglycolates - chemistry</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2013-12, Vol.112, p.255-263</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-ad0276a7ebd0a9766292129afd1528ec499e95fa3b569d2a556bf951096044a03</citedby><cites>FETCH-LOGICAL-c458t-ad0276a7ebd0a9766292129afd1528ec499e95fa3b569d2a556bf951096044a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0927776513005018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23994749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeyadevi, R.</creatorcontrib><creatorcontrib>Sivasudha, T.</creatorcontrib><creatorcontrib>Rameshkumar, A.</creatorcontrib><creatorcontrib>Ananth, D. Arul</creatorcontrib><creatorcontrib>Aseervatham, G. Smilin Bell</creatorcontrib><creatorcontrib>Kumaresan, K.</creatorcontrib><creatorcontrib>Kumar, L. Dinesh</creatorcontrib><creatorcontrib>Jagadeeswari, S.</creatorcontrib><creatorcontrib>Renganathan, R.</creatorcontrib><title>Enhancement of anti arthritic effect of quercetin using thioglycolic acid-capped cadmium telluride quantum dots as nanocarrier in adjuvant induced arthritic Wistar rats</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>•Enhancement of antiarthritic effect of quercetin (QE) using quantum dots (QDs) as nanocarrier.•Quantum dots enhance the efficacy of drug delivery.•QDs-QE complex has brought back the hematological changes in arthritic animals.•Cartilage regeneration in arthritic rats treated with QDs-QE complex was observed.
In this present study, we investigated thio glycolic acid-capped cadmium telluride quantum dots (TGA-CdTe QDs) as nano carrier to study the antiarthritic activity of quercetin on adjuvant induced arthritic Wistar rats. The free radical scavenging activity of QDs-QE complex was evaluated by 2,2′-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and superoxide anion scavenging assays. Fifteen days after adjuvant induction, arthritic rats received QDs-QE complex orally at the dose of 0.2 and 0.4mg/kg daily for 3 weeks. Diclofenac sodium (DF) was used as a reference drug. Administration of QDs-QE complex showed a significant reduction in inflammation and improvement in cartilage regeneration. Treatment with QDs-QE complex significantly (P<0.05) reduced the expressions lipid peroxidation and showed significant (P<0.05) increase in activities of antioxidant enzymes such as superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) catalase (CAT) levels in paw tissue. C-reactive protein (CRP), rheumatoid factor (RF), red blood cells (RBC) and white blood cells (WBC) count and erythrocyte sedimentation rate (ESR) of experimental animals were also estimated. Histology of hind limb tissue in experimental groups confirmed the complete cartilage regeneration in arthritis induced rats treated with QDs-QE complex. Based on our findings, we suggest that the QDs act as nano carrier for the drugs used in the treatment of various degenerative diseases.</description><subject>2,2-diphenyl-1-picrylhydrazyl</subject><subject>Adjuvants</subject><subject>Animals</subject><subject>Anti arthritic</subject><subject>antioxidant activity</subject><subject>Antioxidants - administration & dosage</subject><subject>arthritis</subject><subject>Arthritis, Experimental - blood</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - pathology</subject><subject>C-reactive protein</subject><subject>Cadmium</subject><subject>Cadmium Compounds - chemistry</subject><subject>Carriers</subject><subject>cartilage</subject><subject>catalase</subject><subject>colloids</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>drugs</subject><subject>erythrocyte count</subject><subject>erythrocyte sedimentation rate</subject><subject>erythrocytes</subject><subject>Female</subject><subject>Fluorescence quenching</subject><subject>free radical scavengers</subject><subject>Glutathione</subject><subject>glutathione peroxidase</subject><subject>histology</subject><subject>inflammation</subject><subject>Intermetallics</subject><subject>laboratory animals</subject><subject>leukocytes</subject><subject>lipid peroxidation</subject><subject>Nanocarrier</subject><subject>nanocarriers</subject><subject>Nanostructure</subject><subject>nitric oxide</subject><subject>Particle Size</subject><subject>Quantum dots</subject><subject>Quantum Dots - chemistry</subject><subject>Quantum Dots - ultrastructure</subject><subject>Quercetin</subject><subject>Quercetin - administration & dosage</subject><subject>Radiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Scavenging</subject><subject>Spectrophotometry</subject><subject>superoxide anion</subject><subject>superoxide dismutase</subject><subject>Tellurium - chemistry</subject><subject>Thioglycolates - chemistry</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQxiMEotvCKxQfuSTYjv-sb6CqUKRKHKDiaE1sZ9erTbzYTqW-UR-TKdvCsRwsW_ZvvpnxN01zzmjHKFMfdp1L-7Lkceg4ZX1HdUeVfNGs2Fr3reiVftmsqOG61VrJk-a0lB2llAumXzcnvDdGaGFWzf3lvIXZhSnMlaSRwFwjgVy3OdboSBjH4P48_FpCdqHGmSwlzhtStzFt9ndYBWLgom8dHA7BEwd-istEatjvlxx9wFBUxRufaiFQyAxzcpBzDJmgHvjdcosEnv3iUOFf-p-xVMgkQy1vmlcj7Et4-7ifNTefL39cXLXX3758vfh03Toh17UFT7lWoMPgKRitFDeccQOjZ5KvgxPGBCNH6AepjOcgpRpGIxk1igoBtD9r3h91Dzlhz6XaKRaHvcAc0lIsU5KJnmuq_wMVXDEqdP88KoTha26EQVQdUZdTKTmM9pDjBPnOMmofvLc7--S9ffDeUm3Reww8f8yxDFPwf8OezEbg3REYIVnY5FjszXdUUDgYvcaFxMcjEfCHb9EfW1wMOB4-ZpwD61N8rorfOaDQAQ</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Jeyadevi, R.</creator><creator>Sivasudha, T.</creator><creator>Rameshkumar, A.</creator><creator>Ananth, D. Arul</creator><creator>Aseervatham, G. Smilin Bell</creator><creator>Kumaresan, K.</creator><creator>Kumar, L. Dinesh</creator><creator>Jagadeeswari, S.</creator><creator>Renganathan, R.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7QQ</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20131201</creationdate><title>Enhancement of anti arthritic effect of quercetin using thioglycolic acid-capped cadmium telluride quantum dots as nanocarrier in adjuvant induced arthritic Wistar rats</title><author>Jeyadevi, R. ; Sivasudha, T. ; Rameshkumar, A. ; Ananth, D. Arul ; Aseervatham, G. Smilin Bell ; Kumaresan, K. ; Kumar, L. Dinesh ; Jagadeeswari, S. ; Renganathan, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-ad0276a7ebd0a9766292129afd1528ec499e95fa3b569d2a556bf951096044a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>2,2-diphenyl-1-picrylhydrazyl</topic><topic>Adjuvants</topic><topic>Animals</topic><topic>Anti arthritic</topic><topic>antioxidant activity</topic><topic>Antioxidants - administration & dosage</topic><topic>arthritis</topic><topic>Arthritis, Experimental - blood</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - pathology</topic><topic>C-reactive protein</topic><topic>Cadmium</topic><topic>Cadmium Compounds - chemistry</topic><topic>Carriers</topic><topic>cartilage</topic><topic>catalase</topic><topic>colloids</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>drugs</topic><topic>erythrocyte count</topic><topic>erythrocyte sedimentation rate</topic><topic>erythrocytes</topic><topic>Female</topic><topic>Fluorescence quenching</topic><topic>free radical scavengers</topic><topic>Glutathione</topic><topic>glutathione peroxidase</topic><topic>histology</topic><topic>inflammation</topic><topic>Intermetallics</topic><topic>laboratory animals</topic><topic>leukocytes</topic><topic>lipid peroxidation</topic><topic>Nanocarrier</topic><topic>nanocarriers</topic><topic>Nanostructure</topic><topic>nitric oxide</topic><topic>Particle Size</topic><topic>Quantum dots</topic><topic>Quantum Dots - chemistry</topic><topic>Quantum Dots - ultrastructure</topic><topic>Quercetin</topic><topic>Quercetin - administration & dosage</topic><topic>Radiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Scavenging</topic><topic>Spectrophotometry</topic><topic>superoxide anion</topic><topic>superoxide dismutase</topic><topic>Tellurium - chemistry</topic><topic>Thioglycolates - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeyadevi, R.</creatorcontrib><creatorcontrib>Sivasudha, T.</creatorcontrib><creatorcontrib>Rameshkumar, A.</creatorcontrib><creatorcontrib>Ananth, D. 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Dinesh</creatorcontrib><creatorcontrib>Jagadeeswari, S.</creatorcontrib><creatorcontrib>Renganathan, R.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeyadevi, R.</au><au>Sivasudha, T.</au><au>Rameshkumar, A.</au><au>Ananth, D. Arul</au><au>Aseervatham, G. Smilin Bell</au><au>Kumaresan, K.</au><au>Kumar, L. Dinesh</au><au>Jagadeeswari, S.</au><au>Renganathan, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of anti arthritic effect of quercetin using thioglycolic acid-capped cadmium telluride quantum dots as nanocarrier in adjuvant induced arthritic Wistar rats</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>112</volume><spage>255</spage><epage>263</epage><pages>255-263</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>•Enhancement of antiarthritic effect of quercetin (QE) using quantum dots (QDs) as nanocarrier.•Quantum dots enhance the efficacy of drug delivery.•QDs-QE complex has brought back the hematological changes in arthritic animals.•Cartilage regeneration in arthritic rats treated with QDs-QE complex was observed.
In this present study, we investigated thio glycolic acid-capped cadmium telluride quantum dots (TGA-CdTe QDs) as nano carrier to study the antiarthritic activity of quercetin on adjuvant induced arthritic Wistar rats. The free radical scavenging activity of QDs-QE complex was evaluated by 2,2′-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and superoxide anion scavenging assays. Fifteen days after adjuvant induction, arthritic rats received QDs-QE complex orally at the dose of 0.2 and 0.4mg/kg daily for 3 weeks. Diclofenac sodium (DF) was used as a reference drug. Administration of QDs-QE complex showed a significant reduction in inflammation and improvement in cartilage regeneration. Treatment with QDs-QE complex significantly (P<0.05) reduced the expressions lipid peroxidation and showed significant (P<0.05) increase in activities of antioxidant enzymes such as superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) catalase (CAT) levels in paw tissue. C-reactive protein (CRP), rheumatoid factor (RF), red blood cells (RBC) and white blood cells (WBC) count and erythrocyte sedimentation rate (ESR) of experimental animals were also estimated. Histology of hind limb tissue in experimental groups confirmed the complete cartilage regeneration in arthritis induced rats treated with QDs-QE complex. Based on our findings, we suggest that the QDs act as nano carrier for the drugs used in the treatment of various degenerative diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23994749</pmid><doi>10.1016/j.colsurfb.2013.07.065</doi><tpages>9</tpages></addata></record> |
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| ispartof | Colloids and surfaces, B, Biointerfaces, 2013-12, Vol.112, p.255-263 |
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| subjects | 2,2-diphenyl-1-picrylhydrazyl Adjuvants Animals Anti arthritic antioxidant activity Antioxidants - administration & dosage arthritis Arthritis, Experimental - blood Arthritis, Experimental - drug therapy Arthritis, Experimental - pathology C-reactive protein Cadmium Cadmium Compounds - chemistry Carriers cartilage catalase colloids Drug Carriers - chemistry Drug Delivery Systems drugs erythrocyte count erythrocyte sedimentation rate erythrocytes Female Fluorescence quenching free radical scavengers Glutathione glutathione peroxidase histology inflammation Intermetallics laboratory animals leukocytes lipid peroxidation Nanocarrier nanocarriers Nanostructure nitric oxide Particle Size Quantum dots Quantum Dots - chemistry Quantum Dots - ultrastructure Quercetin Quercetin - administration & dosage Radiology Rats Rats, Wistar Scavenging Spectrophotometry superoxide anion superoxide dismutase Tellurium - chemistry Thioglycolates - chemistry |
| title | Enhancement of anti arthritic effect of quercetin using thioglycolic acid-capped cadmium telluride quantum dots as nanocarrier in adjuvant induced arthritic Wistar rats |
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