Biotransformation of curcumin for improved biological activity and antiproliferative activity on acute HT-29 human cell lines
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-l,6-heptadiene-3,5-dione) is a natural hydrophobic polyphenol compound isolated from rhizomes of the herb Curcuma longa Linn. It has diverse pharmacological properties including antiinflammatory, antioxidant, antiproliferative and antiangiogenic activitie...
Gespeichert in:
| Veröffentlicht in: | Indian journal of biotechnology 2014-07, Vol.13 (3), p.324-329 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 329 |
|---|---|
| container_issue | 3 |
| container_start_page | 324 |
| container_title | Indian journal of biotechnology |
| container_volume | 13 |
| creator | Prasad, E Hameeda, B Rao, A Bhaskar Reddy, Gopal |
| description | Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-l,6-heptadiene-3,5-dione) is a natural hydrophobic polyphenol compound isolated from rhizomes of the herb Curcuma longa Linn. It has diverse pharmacological properties including antiinflammatory, antioxidant, antiproliferative and antiangiogenic activities. However, use of curcumin is limited due to its poor aqueous solubility resulting in reduced concentration of active molecule at target site and low systemic bioavailability. In the present study, conjugated glycosyl-curcumin was synthesized in good yield by biocatalytic method using beta -glucosidase enzyme obtained from almonds and found to be enantioselective. The glucosilated curcumin product showed promising pharmacokinetic and biological (antioxidant, antimicrobial & antiproliferative) properties. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1651429558</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1651429558</sourcerecordid><originalsourceid>FETCH-LOGICAL-p221t-85d26beb784c156c82e47eecb73e4cc8a25a783852eb2c684a5fdb6fc2278bd63</originalsourceid><addsrcrecordid>eNqNkM1LxDAQxYsouKz7P-TopZCm-epRF3WFBS_reUmmUw2kydqkBQ_-78YP8OpheI-Zx4_HnFUr2ilR006q82_PaqF5d1ltUnKWUt2KRrfdqvq4dTFPJqQhTqPJLgYSBwLzBPPoAilb4sbTFBfsiXXRxxcHxhMD2S0uvxMT-jLZlYh3A04FseDfueAMzBnJ7lCzjrzOowkE0HviXcB0VV0Mxifc_Oq6er6_O2x39f7p4XF7s69PjDW51qJn0qJVmkMjJGiGXCGCVS1yAG2YMEq3WjC0DKTmRgy9lQMwprTtZbuurn-4pebbjCkfR5e-apiAcU7HRoqGs04I_Y8oV5SK8t32Ewzlbt0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1647005975</pqid></control><display><type>article</type><title>Biotransformation of curcumin for improved biological activity and antiproliferative activity on acute HT-29 human cell lines</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Prasad, E ; Hameeda, B ; Rao, A Bhaskar ; Reddy, Gopal</creator><creatorcontrib>Prasad, E ; Hameeda, B ; Rao, A Bhaskar ; Reddy, Gopal</creatorcontrib><description>Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-l,6-heptadiene-3,5-dione) is a natural hydrophobic polyphenol compound isolated from rhizomes of the herb Curcuma longa Linn. It has diverse pharmacological properties including antiinflammatory, antioxidant, antiproliferative and antiangiogenic activities. However, use of curcumin is limited due to its poor aqueous solubility resulting in reduced concentration of active molecule at target site and low systemic bioavailability. In the present study, conjugated glycosyl-curcumin was synthesized in good yield by biocatalytic method using beta -glucosidase enzyme obtained from almonds and found to be enantioselective. The glucosilated curcumin product showed promising pharmacokinetic and biological (antioxidant, antimicrobial & antiproliferative) properties.</description><identifier>ISSN: 0972-5849</identifier><identifier>EISSN: 0975-0967</identifier><language>eng</language><subject>Antiinfectives and antibacterials ; Antioxidants ; Antiproliferatives ; Biological ; Biotechnology ; Curcuma longa ; Herbs ; Polyphenols ; Prunus dulcis ; Solubility</subject><ispartof>Indian journal of biotechnology, 2014-07, Vol.13 (3), p.324-329</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Prasad, E</creatorcontrib><creatorcontrib>Hameeda, B</creatorcontrib><creatorcontrib>Rao, A Bhaskar</creatorcontrib><creatorcontrib>Reddy, Gopal</creatorcontrib><title>Biotransformation of curcumin for improved biological activity and antiproliferative activity on acute HT-29 human cell lines</title><title>Indian journal of biotechnology</title><description>Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-l,6-heptadiene-3,5-dione) is a natural hydrophobic polyphenol compound isolated from rhizomes of the herb Curcuma longa Linn. It has diverse pharmacological properties including antiinflammatory, antioxidant, antiproliferative and antiangiogenic activities. However, use of curcumin is limited due to its poor aqueous solubility resulting in reduced concentration of active molecule at target site and low systemic bioavailability. In the present study, conjugated glycosyl-curcumin was synthesized in good yield by biocatalytic method using beta -glucosidase enzyme obtained from almonds and found to be enantioselective. The glucosilated curcumin product showed promising pharmacokinetic and biological (antioxidant, antimicrobial & antiproliferative) properties.</description><subject>Antiinfectives and antibacterials</subject><subject>Antioxidants</subject><subject>Antiproliferatives</subject><subject>Biological</subject><subject>Biotechnology</subject><subject>Curcuma longa</subject><subject>Herbs</subject><subject>Polyphenols</subject><subject>Prunus dulcis</subject><subject>Solubility</subject><issn>0972-5849</issn><issn>0975-0967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkM1LxDAQxYsouKz7P-TopZCm-epRF3WFBS_reUmmUw2kydqkBQ_-78YP8OpheI-Zx4_HnFUr2ilR006q82_PaqF5d1ltUnKWUt2KRrfdqvq4dTFPJqQhTqPJLgYSBwLzBPPoAilb4sbTFBfsiXXRxxcHxhMD2S0uvxMT-jLZlYh3A04FseDfueAMzBnJ7lCzjrzOowkE0HviXcB0VV0Mxifc_Oq6er6_O2x39f7p4XF7s69PjDW51qJn0qJVmkMjJGiGXCGCVS1yAG2YMEq3WjC0DKTmRgy9lQMwprTtZbuurn-4pebbjCkfR5e-apiAcU7HRoqGs04I_Y8oV5SK8t32Ewzlbt0</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Prasad, E</creator><creator>Hameeda, B</creator><creator>Rao, A Bhaskar</creator><creator>Reddy, Gopal</creator><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7TB</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20140701</creationdate><title>Biotransformation of curcumin for improved biological activity and antiproliferative activity on acute HT-29 human cell lines</title><author>Prasad, E ; Hameeda, B ; Rao, A Bhaskar ; Reddy, Gopal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p221t-85d26beb784c156c82e47eecb73e4cc8a25a783852eb2c684a5fdb6fc2278bd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antiinfectives and antibacterials</topic><topic>Antioxidants</topic><topic>Antiproliferatives</topic><topic>Biological</topic><topic>Biotechnology</topic><topic>Curcuma longa</topic><topic>Herbs</topic><topic>Polyphenols</topic><topic>Prunus dulcis</topic><topic>Solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prasad, E</creatorcontrib><creatorcontrib>Hameeda, B</creatorcontrib><creatorcontrib>Rao, A Bhaskar</creatorcontrib><creatorcontrib>Reddy, Gopal</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Indian journal of biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prasad, E</au><au>Hameeda, B</au><au>Rao, A Bhaskar</au><au>Reddy, Gopal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biotransformation of curcumin for improved biological activity and antiproliferative activity on acute HT-29 human cell lines</atitle><jtitle>Indian journal of biotechnology</jtitle><date>2014-07-01</date><risdate>2014</risdate><volume>13</volume><issue>3</issue><spage>324</spage><epage>329</epage><pages>324-329</pages><issn>0972-5849</issn><eissn>0975-0967</eissn><abstract>Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-l,6-heptadiene-3,5-dione) is a natural hydrophobic polyphenol compound isolated from rhizomes of the herb Curcuma longa Linn. It has diverse pharmacological properties including antiinflammatory, antioxidant, antiproliferative and antiangiogenic activities. However, use of curcumin is limited due to its poor aqueous solubility resulting in reduced concentration of active molecule at target site and low systemic bioavailability. In the present study, conjugated glycosyl-curcumin was synthesized in good yield by biocatalytic method using beta -glucosidase enzyme obtained from almonds and found to be enantioselective. The glucosilated curcumin product showed promising pharmacokinetic and biological (antioxidant, antimicrobial & antiproliferative) properties.</abstract><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0972-5849 |
| ispartof | Indian journal of biotechnology, 2014-07, Vol.13 (3), p.324-329 |
| issn | 0972-5849 0975-0967 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1651429558 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Antiinfectives and antibacterials Antioxidants Antiproliferatives Biological Biotechnology Curcuma longa Herbs Polyphenols Prunus dulcis Solubility |
| title | Biotransformation of curcumin for improved biological activity and antiproliferative activity on acute HT-29 human cell lines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T04%3A53%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biotransformation%20of%20curcumin%20for%20improved%20biological%20activity%20and%20antiproliferative%20activity%20on%20acute%20HT-29%20human%20cell%20lines&rft.jtitle=Indian%20journal%20of%20biotechnology&rft.au=Prasad,%20E&rft.date=2014-07-01&rft.volume=13&rft.issue=3&rft.spage=324&rft.epage=329&rft.pages=324-329&rft.issn=0972-5849&rft.eissn=0975-0967&rft_id=info:doi/&rft_dat=%3Cproquest%3E1651429558%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1647005975&rft_id=info:pmid/&rfr_iscdi=true |