Controlled release and antibacterial activity of antibiotic-loaded electrospun halloysite/poly(lactic-co-glycolic acid) composite nanofibers

•Incorporation of TCH-loaded HNTs improves the tensile strength of the nanofibrous mat.•Incorporation of TCH-loaded HNTs does not appreciably alter the mat morphology.•TCH/HNTs/PLGA composite nanofibers are cytocompatible.•TCH/HNTs/PLGA composite nanofibers are able to release TCH in a sustained man...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2013-10, Vol.110, p.148-155
Hauptverfasser:	Qi, Ruiling, Guo, Rui, Zheng, Fuyin, Liu, Hui, Yu, Jianyong, Shi, Xiangyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity antibacterial properties Antiinfectives and antibacterials Cells, Cultured colloids Controlled release cultured cells Dose-Response Relationship, Drug Drug Delivery Systems Drugs durability Electrospinning Electrospun nanofibers encapsulation fibroblasts Fibroblasts - drug effects Fourier transform infrared spectroscopy halloysite Halloysite nanotubes Lactic Acid - chemistry Mice Microbial Sensitivity Tests Nanofibers Nanofibers - chemistry Nanostructure nanotubes Nanotubes - chemistry Particle Size Polyglycolic Acid - chemistry Porosity Scanning electron microscopy Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Structure-Activity Relationship Surface Properties tensile strength tetracycline Tetracycline - chemical synthesis Tetracycline - chemistry Tetracycline - pharmacology Tetracycline hydrochloride tissue engineering viability
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