DNA impedance biosensor for detection of cancer, TP53 gene mutation, based on gold nanoparticles/aligned carbon nanotubes modified electrode

[Display omitted] •Aligned MWCNT/Au nanoparticles electrode was fabricated to use as a new DNA biosensor.•EIS was proposed for DNA detection of the TP53 gene mutation for the first time.•A low detection limit (1.0×10−17M) was obtained without any amplification.•The biosensor exhibited high sensitivi...

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Veröffentlicht in:	Analytica chimica acta 2014-07, Vol.836, p.34-44
Hauptverfasser:	Fayazfar, H., Afshar, A., Dolati, M., Dolati, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alignment Biosensing Techniques - instrumentation Biosensing Techniques - methods Deoxyribonucleic acid Dielectric Spectroscopy DNA Mutational Analysis - methods DNA Probes - genetics Electrochemical impedance sensor Electrochemical impedance spectroscopy Electrochemical Techniques Electrodes Gene mutation Genes Genes, p53 Gold Gold nanoparticle Humans Hybridization Limit of Detection Multi-walled carbon nanotube Mutations Nanoparticles Nanotubes, Carbon Neoplasms - genetics Nucleic Acid Hybridization Reproducibility of Results
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