Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats—An in vivo approach
•AuNPs were characterized using microscopic and spectroscopic analyses.•Antihyperglycemic activity of Gymnema sylvestre mediated AuNPs.•Anti-inflammatory effect studied using IL-6, TNF-α and CRP markers. Development of novel antidiabetic agents using various organic compounds and biomolecules has be...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-10, Vol.122, p.505-511 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Karthick, V. Kumar, V. Ganesh Dhas, T. Stalin Singaravelu, G. Sadiq, A. Mohamed Govindaraju, K. |
| description | •AuNPs were characterized using microscopic and spectroscopic analyses.•Antihyperglycemic activity of Gymnema sylvestre mediated AuNPs.•Anti-inflammatory effect studied using IL-6, TNF-α and CRP markers.
Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic activity of gold nanoparticles (AuNPs) synthesized using the antidiabetic potent plant Gymnema sylvestre R. Br on wistar albino rats has been evaluated. The formation of AuNPs and their morphology were confirmed using spectroscopic and microscopic analyses, respectively. The treatment of AuNPs has shown significant reduction in blood glucose level on diabetic rats. AuNPs were also tested for its anti-inflammatory effect by estimating the serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and high-sensitive C-reactive protein (CRP). |
| doi_str_mv | 10.1016/j.colsurfb.2014.07.022 |
| format | Article |
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Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic activity of gold nanoparticles (AuNPs) synthesized using the antidiabetic potent plant Gymnema sylvestre R. Br on wistar albino rats has been evaluated. The formation of AuNPs and their morphology were confirmed using spectroscopic and microscopic analyses, respectively. The treatment of AuNPs has shown significant reduction in blood glucose level on diabetic rats. AuNPs were also tested for its anti-inflammatory effect by estimating the serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and high-sensitive C-reactive protein (CRP).</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2014.07.022</identifier><identifier>PMID: 25092583</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alloxan ; Animals ; Biocompatibility ; Biological effects ; Biomedical materials ; Diabetes ; Diabetes Mellitus, Experimental - therapy ; Electron microscopy ; Gold ; Gold - chemistry ; Gold nanoparticles ; Gymnema sylvestre ; Hypoglycemia ; In vivo testing ; In vivo tests ; Metal Nanoparticles ; Microscopy, Atomic Force ; Rats ; Rats, Wistar ; Spectrophotometry, Ultraviolet ; Surgical implants</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2014-10, Vol.122, p.505-511</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-c57615a4f25e92fdb30fa152e6a7a9fc0dd8e1bd0771c22c5eb45fb5b4e429233</citedby><cites>FETCH-LOGICAL-c504t-c57615a4f25e92fdb30fa152e6a7a9fc0dd8e1bd0771c22c5eb45fb5b4e429233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0927776514003841$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25092583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karthick, V.</creatorcontrib><creatorcontrib>Kumar, V. Ganesh</creatorcontrib><creatorcontrib>Dhas, T. Stalin</creatorcontrib><creatorcontrib>Singaravelu, G.</creatorcontrib><creatorcontrib>Sadiq, A. Mohamed</creatorcontrib><creatorcontrib>Govindaraju, K.</creatorcontrib><title>Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats—An in vivo approach</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>•AuNPs were characterized using microscopic and spectroscopic analyses.•Antihyperglycemic activity of Gymnema sylvestre mediated AuNPs.•Anti-inflammatory effect studied using IL-6, TNF-α and CRP markers.
Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic activity of gold nanoparticles (AuNPs) synthesized using the antidiabetic potent plant Gymnema sylvestre R. Br on wistar albino rats has been evaluated. The formation of AuNPs and their morphology were confirmed using spectroscopic and microscopic analyses, respectively. The treatment of AuNPs has shown significant reduction in blood glucose level on diabetic rats. AuNPs were also tested for its anti-inflammatory effect by estimating the serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and high-sensitive C-reactive protein (CRP).</description><subject>Alloxan</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biological effects</subject><subject>Biomedical materials</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Electron microscopy</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Gold nanoparticles</subject><subject>Gymnema sylvestre</subject><subject>Hypoglycemia</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Metal Nanoparticles</subject><subject>Microscopy, Atomic Force</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Surgical implants</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9uEzEQhy1ERUPLK1Q-ctnF9trr5EZVtRSpEhc4W_4zbh05drB3I8KJh-gT8iR1lJZrkaXxYb6ZnzQfQheU9JTQ8dO6tznWuXjTM0J5T2RPGHuDFnQph44Po3yLFmTFZCflKE7R-1rXhBDGqXyHTploLbEcFiheew92wtljE3LM98HqGPe47tP0ADX8Bofvc3Q46ZS3ukzBRqg4J9yw_EunLiQ320a5oA20Ni56qn__PF4mHBLehV3GerstWduHc3Tidazw4fk_Qz9urr9f3XZ33758vbq866wgfGpVjlRo7pmAFfPODMRrKhiMWuqVt8S5JVDjiJTUMmYFGC68EYYDZys2DGfo43Fvi_05Q53UJlQLMeoEea6KjoLy9sj_oLydjUjCXkfFyAdBpTxsHY-oLbnWAl5tS9josleUqIM_tVYv_tTBnyJSNX9t8OI5YzYbcP_GXoQ14PMRgHa_XYCiqg2QmoBQmkflcngt4wnF47GZ</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Karthick, V.</creator><creator>Kumar, V. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alloxan Animals Biocompatibility Biological effects Biomedical materials Diabetes Diabetes Mellitus, Experimental - therapy Electron microscopy Gold Gold - chemistry Gold nanoparticles Gymnema sylvestre Hypoglycemia In vivo testing In vivo tests Metal Nanoparticles Microscopy, Atomic Force Rats Rats, Wistar Spectrophotometry, Ultraviolet Surgical implants |
| title | Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats—An in vivo approach |
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