Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice

ABSTRACT Drug‐induced liver injury (DILI) is a serious problem in pre‐clinical stages of drug development and clinical pharmacotherapy, but the pathogenesis of DILI has not been elucidated. Flucloxacillin (FLX), which is a β‐lactam antibiotic of the penicillin class that is used widely in Europe and...

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Veröffentlicht in:	Journal of applied toxicology 2015-02, Vol.35 (2), p.142-151
Hauptverfasser:	Takai, Shohei, Higuchi, Satonori, Yano, Azusa, Tsuneyama, Koichi, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Anti-Bacterial Agents - toxicity Antibiotics Aspartate Aminotransferases - blood Bilirubin - blood Biocompatibility Calgranulin A - blood Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - immunology Chemical and Drug Induced Liver Injury - physiopathology Cytokines Dose-Response Relationship, Drug Female Floxacillin - toxicity flucloxacillin Glutathione - analysis HMGB1 Protein - blood IL-17 inflammatory Injuries Interleukin-17 - pharmacology Liver Liver - chemistry Liver - drug effects Liver - immunology Mice Mice, Inbred BALB C Penicillin Pharmacology Protein Carbonylation - drug effects Proteins Real-Time Polymerase Chain Reaction Recombinant S100 Calcium Binding Protein beta Subunit - blood Side effects toll-like receptor 4 (TLR4) Toxicity
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