A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules
The oral delivery of proteins and peptides is a dynamic research field despite the numerous challenges limiting their effective delivery. Successful oral delivery of proteins and peptides requires the accomplishment of three key tasks: protection of the macromolecules from degradation in the gastroi...
Gespeichert in:
| Veröffentlicht in: | Biotechnology advances 2014-11, Vol.32 (7), p.1269-1282 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1282 |
|---|---|
| container_issue | 7 |
| container_start_page | 1269 |
| container_title | Biotechnology advances |
| container_volume | 32 |
| creator | Choonara, Bibi F. Choonara, Yahya E. Kumar, Pradeep Bijukumar, Divya du Toit, Lisa C. Pillay, Viness |
| description | The oral delivery of proteins and peptides is a dynamic research field despite the numerous challenges limiting their effective delivery. Successful oral delivery of proteins and peptides requires the accomplishment of three key tasks: protection of the macromolecules from degradation in the gastrointestinal tract (GIT), permeation through the intestinal barrier and absorption of molecules into the systemic circulation. Currently, no clinically useful oral formulations have been developed but several attempts have been made to overcome the challenges of low oral bioavailability resulting from poor absorption, poor permeation and enzymatic degradation of the proteins and peptides in the GIT. Present strategies attempt to provide structural protection of the proteins and peptides and improved absorption through the use of enzyme inhibitors, absorption enhancers, novel polymeric delivery systems and chemical modification. However, each of these technologies has their limitations despite showing positive results. This review attempts to discuss the physical and chemical barriers of the GIT with particular emphasis on the current approaches employed to overcome these barriers, including the evaluation of other non-parenteral routes of protein and peptide delivery. In addition, this review assimilates oral formulation strategies under development and within the clinical trial stage in relation to their benefits and drawbacks with regard to facilitating optimal protection and absorption of proteins and peptides, as well as pertinent future challenges and opportunities governing oral drug delivery.
•Discusses current approaches to overcome GIT absorption barriers for macromolecules•Elaborates on advanced oral macromolecular technologies for clinical application•Critically evaluates oral macromolecule systems developed and in clinical trials•Provides a critical analysis of the inherent pharmacokinetic advancements |
| doi_str_mv | 10.1016/j.biotechadv.2014.07.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1651381497</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0734975014001116</els_id><sourcerecordid>1620584955</sourcerecordid><originalsourceid>FETCH-LOGICAL-c577t-b676adb9e24361b7c1cd22e10cb22aceaa8bd36304d4dc8f826f0fd694803573</originalsourceid><addsrcrecordid>eNqNkctu1DAUQC0EokPhF5A3SGwS7Dh-LUvFS6rEpnvLsW-mHnniwU4GdddPx-kMdEm9sXzvuQ_5IIQpaSmh4tOuHUKawd1Zf2w7QvuWyJYQ8QJtqJKsoUrrl2hDJOsbLTm5QG9K2RFCOeHsNbroONFacLlBD1c4wzHAb5xGXLvZyYHHKduIfV622EMMR8j3eJ02pZi2AQoerQsxzHYO0xbPd4APeV1nDmnCdvLYDiXlw-Oztn1MhlPmADXsAe9TBLdEKG_Rq9HGAu_O9yW6_frl9vp7c_Pz24_rq5vGcSnnZhBSWD9o6Hom6CAddb7rgBI3dJ11YK0aPBOM9L73To2qEyMZvdC9IoxLdok-ntrWZX4tUGazD8VBjHaCtBRDBadM0V4_B2VaK82ehXaEq15zXlF1Ql1OpWQYzSGHvc33hhKzSjU78yTVrFINkaZKraXvz1OWYQ_-X-FfixX4cAZscTaOuVoM5YlTitZDKvf5xEH96Co9m-ICrMZDrvaMT-H_2_wB6RDHMw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1620584955</pqid></control><display><type>article</type><title>A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Choonara, Bibi F. ; Choonara, Yahya E. ; Kumar, Pradeep ; Bijukumar, Divya ; du Toit, Lisa C. ; Pillay, Viness</creator><creatorcontrib>Choonara, Bibi F. ; Choonara, Yahya E. ; Kumar, Pradeep ; Bijukumar, Divya ; du Toit, Lisa C. ; Pillay, Viness</creatorcontrib><description>The oral delivery of proteins and peptides is a dynamic research field despite the numerous challenges limiting their effective delivery. Successful oral delivery of proteins and peptides requires the accomplishment of three key tasks: protection of the macromolecules from degradation in the gastrointestinal tract (GIT), permeation through the intestinal barrier and absorption of molecules into the systemic circulation. Currently, no clinically useful oral formulations have been developed but several attempts have been made to overcome the challenges of low oral bioavailability resulting from poor absorption, poor permeation and enzymatic degradation of the proteins and peptides in the GIT. Present strategies attempt to provide structural protection of the proteins and peptides and improved absorption through the use of enzyme inhibitors, absorption enhancers, novel polymeric delivery systems and chemical modification. However, each of these technologies has their limitations despite showing positive results. This review attempts to discuss the physical and chemical barriers of the GIT with particular emphasis on the current approaches employed to overcome these barriers, including the evaluation of other non-parenteral routes of protein and peptide delivery. In addition, this review assimilates oral formulation strategies under development and within the clinical trial stage in relation to their benefits and drawbacks with regard to facilitating optimal protection and absorption of proteins and peptides, as well as pertinent future challenges and opportunities governing oral drug delivery.
•Discusses current approaches to overcome GIT absorption barriers for macromolecules•Elaborates on advanced oral macromolecular technologies for clinical application•Critically evaluates oral macromolecule systems developed and in clinical trials•Provides a critical analysis of the inherent pharmacokinetic advancements</description><identifier>ISSN: 0734-9750</identifier><identifier>EISSN: 1873-1899</identifier><identifier>DOI: 10.1016/j.biotechadv.2014.07.006</identifier><identifier>PMID: 25099657</identifier><identifier>CODEN: BIADDD</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>Administration, Oral ; Advanced oral biotechnology ; Animals ; Barriers ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Biotechnology ; Degradation ; Drug Carriers ; Drug Delivery Systems ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal barrier ; Humans ; Inhibitors ; Intestinal Absorption ; Mice ; Models, Biological ; Oral drug delivery ; Penetration ; Peptides ; Peptides - administration & dosage ; Peptides - pharmacokinetics ; Permeation ; Proteins ; Proteins - administration & dosage ; Proteins - pharmacokinetics ; Therapeutic proteins and peptides</subject><ispartof>Biotechnology advances, 2014-11, Vol.32 (7), p.1269-1282</ispartof><rights>2014 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-b676adb9e24361b7c1cd22e10cb22aceaa8bd36304d4dc8f826f0fd694803573</citedby><cites>FETCH-LOGICAL-c577t-b676adb9e24361b7c1cd22e10cb22aceaa8bd36304d4dc8f826f0fd694803573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biotechadv.2014.07.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28811110$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25099657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choonara, Bibi F.</creatorcontrib><creatorcontrib>Choonara, Yahya E.</creatorcontrib><creatorcontrib>Kumar, Pradeep</creatorcontrib><creatorcontrib>Bijukumar, Divya</creatorcontrib><creatorcontrib>du Toit, Lisa C.</creatorcontrib><creatorcontrib>Pillay, Viness</creatorcontrib><title>A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules</title><title>Biotechnology advances</title><addtitle>Biotechnol Adv</addtitle><description>The oral delivery of proteins and peptides is a dynamic research field despite the numerous challenges limiting their effective delivery. Successful oral delivery of proteins and peptides requires the accomplishment of three key tasks: protection of the macromolecules from degradation in the gastrointestinal tract (GIT), permeation through the intestinal barrier and absorption of molecules into the systemic circulation. Currently, no clinically useful oral formulations have been developed but several attempts have been made to overcome the challenges of low oral bioavailability resulting from poor absorption, poor permeation and enzymatic degradation of the proteins and peptides in the GIT. Present strategies attempt to provide structural protection of the proteins and peptides and improved absorption through the use of enzyme inhibitors, absorption enhancers, novel polymeric delivery systems and chemical modification. However, each of these technologies has their limitations despite showing positive results. This review attempts to discuss the physical and chemical barriers of the GIT with particular emphasis on the current approaches employed to overcome these barriers, including the evaluation of other non-parenteral routes of protein and peptide delivery. In addition, this review assimilates oral formulation strategies under development and within the clinical trial stage in relation to their benefits and drawbacks with regard to facilitating optimal protection and absorption of proteins and peptides, as well as pertinent future challenges and opportunities governing oral drug delivery.
•Discusses current approaches to overcome GIT absorption barriers for macromolecules•Elaborates on advanced oral macromolecular technologies for clinical application•Critically evaluates oral macromolecule systems developed and in clinical trials•Provides a critical analysis of the inherent pharmacokinetic advancements</description><subject>Administration, Oral</subject><subject>Advanced oral biotechnology</subject><subject>Animals</subject><subject>Barriers</subject><subject>Bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Biotechnology</subject><subject>Degradation</subject><subject>Drug Carriers</subject><subject>Drug Delivery Systems</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal barrier</subject><subject>Humans</subject><subject>Inhibitors</subject><subject>Intestinal Absorption</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Oral drug delivery</subject><subject>Penetration</subject><subject>Peptides</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - pharmacokinetics</subject><subject>Permeation</subject><subject>Proteins</subject><subject>Proteins - administration & dosage</subject><subject>Proteins - pharmacokinetics</subject><subject>Therapeutic proteins and peptides</subject><issn>0734-9750</issn><issn>1873-1899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUQC0EokPhF5A3SGwS7Dh-LUvFS6rEpnvLsW-mHnniwU4GdddPx-kMdEm9sXzvuQ_5IIQpaSmh4tOuHUKawd1Zf2w7QvuWyJYQ8QJtqJKsoUrrl2hDJOsbLTm5QG9K2RFCOeHsNbroONFacLlBD1c4wzHAb5xGXLvZyYHHKduIfV622EMMR8j3eJ02pZi2AQoerQsxzHYO0xbPd4APeV1nDmnCdvLYDiXlw-Oztn1MhlPmADXsAe9TBLdEKG_Rq9HGAu_O9yW6_frl9vp7c_Pz24_rq5vGcSnnZhBSWD9o6Hom6CAddb7rgBI3dJ11YK0aPBOM9L73To2qEyMZvdC9IoxLdok-ntrWZX4tUGazD8VBjHaCtBRDBadM0V4_B2VaK82ehXaEq15zXlF1Ql1OpWQYzSGHvc33hhKzSjU78yTVrFINkaZKraXvz1OWYQ_-X-FfixX4cAZscTaOuVoM5YlTitZDKvf5xEH96Co9m-ICrMZDrvaMT-H_2_wB6RDHMw</recordid><startdate>20141115</startdate><enddate>20141115</enddate><creator>Choonara, Bibi F.</creator><creator>Choonara, Yahya E.</creator><creator>Kumar, Pradeep</creator><creator>Bijukumar, Divya</creator><creator>du Toit, Lisa C.</creator><creator>Pillay, Viness</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20141115</creationdate><title>A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules</title><author>Choonara, Bibi F. ; Choonara, Yahya E. ; Kumar, Pradeep ; Bijukumar, Divya ; du Toit, Lisa C. ; Pillay, Viness</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-b676adb9e24361b7c1cd22e10cb22aceaa8bd36304d4dc8f826f0fd694803573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Advanced oral biotechnology</topic><topic>Animals</topic><topic>Barriers</topic><topic>Bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Biotechnology</topic><topic>Degradation</topic><topic>Drug Carriers</topic><topic>Drug Delivery Systems</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal barrier</topic><topic>Humans</topic><topic>Inhibitors</topic><topic>Intestinal Absorption</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Oral drug delivery</topic><topic>Penetration</topic><topic>Peptides</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - pharmacokinetics</topic><topic>Permeation</topic><topic>Proteins</topic><topic>Proteins - administration & dosage</topic><topic>Proteins - pharmacokinetics</topic><topic>Therapeutic proteins and peptides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choonara, Bibi F.</creatorcontrib><creatorcontrib>Choonara, Yahya E.</creatorcontrib><creatorcontrib>Kumar, Pradeep</creatorcontrib><creatorcontrib>Bijukumar, Divya</creatorcontrib><creatorcontrib>du Toit, Lisa C.</creatorcontrib><creatorcontrib>Pillay, Viness</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biotechnology advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choonara, Bibi F.</au><au>Choonara, Yahya E.</au><au>Kumar, Pradeep</au><au>Bijukumar, Divya</au><au>du Toit, Lisa C.</au><au>Pillay, Viness</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules</atitle><jtitle>Biotechnology advances</jtitle><addtitle>Biotechnol Adv</addtitle><date>2014-11-15</date><risdate>2014</risdate><volume>32</volume><issue>7</issue><spage>1269</spage><epage>1282</epage><pages>1269-1282</pages><issn>0734-9750</issn><eissn>1873-1899</eissn><coden>BIADDD</coden><abstract>The oral delivery of proteins and peptides is a dynamic research field despite the numerous challenges limiting their effective delivery. Successful oral delivery of proteins and peptides requires the accomplishment of three key tasks: protection of the macromolecules from degradation in the gastrointestinal tract (GIT), permeation through the intestinal barrier and absorption of molecules into the systemic circulation. Currently, no clinically useful oral formulations have been developed but several attempts have been made to overcome the challenges of low oral bioavailability resulting from poor absorption, poor permeation and enzymatic degradation of the proteins and peptides in the GIT. Present strategies attempt to provide structural protection of the proteins and peptides and improved absorption through the use of enzyme inhibitors, absorption enhancers, novel polymeric delivery systems and chemical modification. However, each of these technologies has their limitations despite showing positive results. This review attempts to discuss the physical and chemical barriers of the GIT with particular emphasis on the current approaches employed to overcome these barriers, including the evaluation of other non-parenteral routes of protein and peptide delivery. In addition, this review assimilates oral formulation strategies under development and within the clinical trial stage in relation to their benefits and drawbacks with regard to facilitating optimal protection and absorption of proteins and peptides, as well as pertinent future challenges and opportunities governing oral drug delivery.
•Discusses current approaches to overcome GIT absorption barriers for macromolecules•Elaborates on advanced oral macromolecular technologies for clinical application•Critically evaluates oral macromolecule systems developed and in clinical trials•Provides a critical analysis of the inherent pharmacokinetic advancements</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>25099657</pmid><doi>10.1016/j.biotechadv.2014.07.006</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0734-9750 |
| ispartof | Biotechnology advances, 2014-11, Vol.32 (7), p.1269-1282 |
| issn | 0734-9750 1873-1899 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1651381497 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Administration, Oral Advanced oral biotechnology Animals Barriers Bioavailability Biological and medical sciences Biological Availability Biotechnology Degradation Drug Carriers Drug Delivery Systems Fundamental and applied biological sciences. Psychology Gastrointestinal barrier Humans Inhibitors Intestinal Absorption Mice Models, Biological Oral drug delivery Penetration Peptides Peptides - administration & dosage Peptides - pharmacokinetics Permeation Proteins Proteins - administration & dosage Proteins - pharmacokinetics Therapeutic proteins and peptides |
| title | A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T01%3A55%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20review%20of%20advanced%20oral%20drug%20delivery%20technologies%20facilitating%20the%20protection%20and%20absorption%20of%20protein%20and%20peptide%20molecules&rft.jtitle=Biotechnology%20advances&rft.au=Choonara,%20Bibi%20F.&rft.date=2014-11-15&rft.volume=32&rft.issue=7&rft.spage=1269&rft.epage=1282&rft.pages=1269-1282&rft.issn=0734-9750&rft.eissn=1873-1899&rft.coden=BIADDD&rft_id=info:doi/10.1016/j.biotechadv.2014.07.006&rft_dat=%3Cproquest_cross%3E1620584955%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1620584955&rft_id=info:pmid/25099657&rft_els_id=S0734975014001116&rfr_iscdi=true |