Impact of fetal nicotine exposure on development of rat brain regions: Critical sensitive periods or effects of withdrawal?

Fetal nicotine exposure evokes alterations in central nervous system structural, neurochemical, and behavioral development. In the current study, the relative importance of critical developmental exposure periods and withdrawal were examined by infusing nicotine to pregnant rats using osmotic minipu...

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Veröffentlicht in:	Brain research bulletin 1993, Vol.31 (3), p.319-328
Hauptverfasser:	Slotkin, T.A., Lappi, S.E., Seidler, F.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - physiology Biological and medical sciences Birth Weight - drug effects Body Weight - drug effects Brain - drug effects Brain - enzymology Brain - growth & development Cell Differentiation - physiology Cell Division - physiology Dendrites - physiology Female Medical sciences Membranes - drug effects Membranes - metabolism Nicotine - toxicity Nicotine effects on brain development Organ Size - drug effects Ornithine Decarboxylase - metabolism Ornithine decarboxylase in developing brain Pregnancy Rats Rats, Sprague-Dawley Receptors, Nicotinic - drug effects Substance Withdrawal Syndrome - enzymology Substance Withdrawal Syndrome - physiopathology Tobacco, tobacco smoking Toxicology
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