Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase

Chimpanzees were challenged with HIV-1 IIIB while receiving a short regimen of nevirapine (Viramune), a nonnucleoside inhibitor of HIV-1 reverse transcriptase. The untreated, control chimpanzee developed an infection characterized by seroconversion, viremia in peripheral blood mononuclear cells (PBM...

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Veröffentlicht in:	Nature medicine 1997-06, Vol.3 (6), p.665-670
Hauptverfasser:	Grob, Peter M., Cao, Yunzhen, Muchmore, Elizabeth, Ho, David D., Norris, Steve, Pav, Joseph W., Shih, Cheng-Kon, Adams, Julian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - pharmacology Biomedical and Life Sciences Biomedicine Cancer Research DNA, Viral - blood HIV Antibodies - blood HIV Infections - prevention & control HIV-1 - drug effects Infectious Diseases Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Metabolic Diseases Molecular Medicine Neurosciences Nevirapine Pan troglodytes Phytohemagglutinins - pharmacology Pyridines - blood Pyridines - therapeutic use Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - blood Tetanus Toxoid - pharmacology Tetradecanoylphorbol Acetate - pharmacology Time Factors
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