Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats
In our previous studies, butyl benzyl phthalate (BBP) was found to be embryolethal and teratogenic in rats. In this study, the reproductive effects of BBP were investigated in pregnant and pseudopregnant rats. Rats were given BBP by gastric intubation at 0, 250, 500, 750, or 1000 mg/kg on Days 0 to...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1998-03, Vol.12 (2), p.127-132 |
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| container_title | Reproductive toxicology (Elmsford, N.Y.) |
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| creator | Ema, Makoto Miyawaki, Emiko Kawashima, Kunio |
| description | In our previous studies, butyl benzyl phthalate (BBP) was found to be embryolethal and teratogenic in rats. In this study, the reproductive effects of BBP were investigated in pregnant and pseudopregnant rats. Rats were given BBP by gastric intubation at 0, 250, 500, 750, or 1000 mg/kg on Days 0 to 8 of pregnancy and the pregnancy outcome was determined on Day 20 of pregnancy. The same doses of BBP were given to pseudopregnant rats, with an induced decidual cell response on Days 0 to 8 of pseudopregnancy, and the uterine weight on Day 9 served as an index of the uterine decidualization. BBP caused significant increases in the incidences of preimplantation loss in females successfully mated at 1000 mg/kg and of postimplantation loss in females having implantations at 750 mg/kg and above. Uterine decidual growth in pseudopregnant rats was significantly decreased at 750 mg/kg and above. These findings suggest that early embryonic loss due to BBP may be mediated, at least in part, via the suppression of uterine decidualization, an impairment of uterine function. |
| doi_str_mv | 10.1016/S0890-6238(97)00127-5 |
| format | Article |
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In this study, the reproductive effects of BBP were investigated in pregnant and pseudopregnant rats. Rats were given BBP by gastric intubation at 0, 250, 500, 750, or 1000 mg/kg on Days 0 to 8 of pregnancy and the pregnancy outcome was determined on Day 20 of pregnancy. The same doses of BBP were given to pseudopregnant rats, with an induced decidual cell response on Days 0 to 8 of pseudopregnancy, and the uterine weight on Day 9 served as an index of the uterine decidualization. BBP caused significant increases in the incidences of preimplantation loss in females successfully mated at 1000 mg/kg and of postimplantation loss in females having implantations at 750 mg/kg and above. Uterine decidual growth in pseudopregnant rats was significantly decreased at 750 mg/kg and above. These findings suggest that early embryonic loss due to BBP may be mediated, at least in part, via the suppression of uterine decidualization, an impairment of uterine function.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/S0890-6238(97)00127-5</identifier><identifier>PMID: 9535506</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; butyl benzyl phthalate ; Corpus Luteum - drug effects ; decidual cell response ; developmental toxicity ; early embryonic loss ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development - drug effects ; Embryonic Development - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Male ; Organ Size - drug effects ; Ovary - drug effects ; Ovary - pathology ; phthalic acid ester ; Phthalic Acids - toxicity ; Pregnancy ; Progesterone - blood ; Pseudopregnancy ; Rats ; Rats, Wistar ; Reproduction - drug effects ; Teratology. Teratogens ; uterine function ; Uterus - drug effects ; Uterus - pathology</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 1998-03, Vol.12 (2), p.127-132</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-eece94b408b967f1104ff2e7ffd073fcc112a088525cd7ed503e2a9fb36ecf083</citedby><cites>FETCH-LOGICAL-c486t-eece94b408b967f1104ff2e7ffd073fcc112a088525cd7ed503e2a9fb36ecf083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0890623897001275$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2224969$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9535506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ema, Makoto</creatorcontrib><creatorcontrib>Miyawaki, Emiko</creatorcontrib><creatorcontrib>Kawashima, Kunio</creatorcontrib><title>Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>In our previous studies, butyl benzyl phthalate (BBP) was found to be embryolethal and teratogenic in rats. In this study, the reproductive effects of BBP were investigated in pregnant and pseudopregnant rats. Rats were given BBP by gastric intubation at 0, 250, 500, 750, or 1000 mg/kg on Days 0 to 8 of pregnancy and the pregnancy outcome was determined on Day 20 of pregnancy. The same doses of BBP were given to pseudopregnant rats, with an induced decidual cell response on Days 0 to 8 of pseudopregnancy, and the uterine weight on Day 9 served as an index of the uterine decidualization. BBP caused significant increases in the incidences of preimplantation loss in females successfully mated at 1000 mg/kg and of postimplantation loss in females having implantations at 750 mg/kg and above. Uterine decidual growth in pseudopregnant rats was significantly decreased at 750 mg/kg and above. These findings suggest that early embryonic loss due to BBP may be mediated, at least in part, via the suppression of uterine decidualization, an impairment of uterine function.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>butyl benzyl phthalate</subject><subject>Corpus Luteum - drug effects</subject><subject>decidual cell response</subject><subject>developmental toxicity</subject><subject>early embryonic loss</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development - drug effects</subject><subject>Embryonic Development - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Organ Size - drug effects</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>phthalic acid ester</subject><subject>Phthalic Acids - toxicity</subject><subject>Pregnancy</subject><subject>Progesterone - blood</subject><subject>Pseudopregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproduction - drug effects</subject><subject>Teratology. Teratogens</subject><subject>uterine function</subject><subject>Uterus - drug effects</subject><subject>Uterus - pathology</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLHTEUgENp0av2JwizkFIXU08yk9dKimgrCIKt65BJTmrK3JkxyQj66x29l7t1deCc77w-Qo4p_KBAxdkfUBpqwRr1XctTAMpkzT-RFVWyqakE9Zmsdsg-Ocj5PwC0Uss9sqd5wzmIFbm7wymNfnYlPmGFIaAruRpD1c3lua86HF6WMD2UB9vbglUcqinhv8EOpbKDr6aMsx93qWRLPiJfgu0zft3GQ3J_dfn34nd9c_vr-uLnTe1aJUqN6FC3XQuq00IGSqENgaEMwYNsgnOUMgtKccadl-g5NMisDl0j0AVQzSH5tpm7PPA4Yy5mHbPDvrcDjnM2VHDKWiEXkG9Al8acEwYzpbi26dlQMG8uzbtL8ybKaGneXRq-9B1vF8zdGv2uaytvqZ9s6zY724dkBxfzDmOMtVroBTvfYLjIeIqYTHYRB4c-psW28WP84JBXXAmSAA</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Ema, Makoto</creator><creator>Miyawaki, Emiko</creator><creator>Kawashima, Kunio</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19980301</creationdate><title>Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats</title><author>Ema, Makoto ; Miyawaki, Emiko ; Kawashima, Kunio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-eece94b408b967f1104ff2e7ffd073fcc112a088525cd7ed503e2a9fb36ecf083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>butyl benzyl phthalate</topic><topic>Corpus Luteum - drug effects</topic><topic>decidual cell response</topic><topic>developmental toxicity</topic><topic>early embryonic loss</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development - drug effects</topic><topic>Embryonic Development - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Organ Size - drug effects</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>phthalic acid ester</topic><topic>Phthalic Acids - toxicity</topic><topic>Pregnancy</topic><topic>Progesterone - blood</topic><topic>Pseudopregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproduction - drug effects</topic><topic>Teratology. Teratogens</topic><topic>uterine function</topic><topic>Uterus - drug effects</topic><topic>Uterus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ema, Makoto</creatorcontrib><creatorcontrib>Miyawaki, Emiko</creatorcontrib><creatorcontrib>Kawashima, Kunio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ema, Makoto</au><au>Miyawaki, Emiko</au><au>Kawashima, Kunio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>12</volume><issue>2</issue><spage>127</spage><epage>132</epage><pages>127-132</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>In our previous studies, butyl benzyl phthalate (BBP) was found to be embryolethal and teratogenic in rats. In this study, the reproductive effects of BBP were investigated in pregnant and pseudopregnant rats. Rats were given BBP by gastric intubation at 0, 250, 500, 750, or 1000 mg/kg on Days 0 to 8 of pregnancy and the pregnancy outcome was determined on Day 20 of pregnancy. The same doses of BBP were given to pseudopregnant rats, with an induced decidual cell response on Days 0 to 8 of pseudopregnancy, and the uterine weight on Day 9 served as an index of the uterine decidualization. BBP caused significant increases in the incidences of preimplantation loss in females successfully mated at 1000 mg/kg and of postimplantation loss in females having implantations at 750 mg/kg and above. Uterine decidual growth in pseudopregnant rats was significantly decreased at 750 mg/kg and above. These findings suggest that early embryonic loss due to BBP may be mediated, at least in part, via the suppression of uterine decidualization, an impairment of uterine function.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9535506</pmid><doi>10.1016/S0890-6238(97)00127-5</doi><tpages>6</tpages></addata></record> |
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| issn | 0890-6238 1873-1708 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Animals Biological and medical sciences butyl benzyl phthalate Corpus Luteum - drug effects decidual cell response developmental toxicity early embryonic loss Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Embryonic Development - drug effects Female Fundamental and applied biological sciences. Psychology Male Organ Size - drug effects Ovary - drug effects Ovary - pathology phthalic acid ester Phthalic Acids - toxicity Pregnancy Progesterone - blood Pseudopregnancy Rats Rats, Wistar Reproduction - drug effects Teratology. Teratogens uterine function Uterus - drug effects Uterus - pathology |
| title | Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats |
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