Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization

S100 proteins are a family of small dimeric proteins characterized by two EF hand type Ca2+ binding motifs which are flanked by unique N- and C-terminal regions. Although shown unequivocally in only a few cases S100 proteins are thought to function by binding to, and thereby regulating, cellular tar...

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Veröffentlicht in:	Cell calcium (Edinburgh) 1998-08, Vol.24 (2), p.137-151
Hauptverfasser:	Osterloh, D, Ivanenkov, V V, Gerke, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Calcium - metabolism Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism CapZ Actin Capping Protein Cross-Linking Reagents Dimerization Microfilament Proteins Molecular Sequence Data Muscle Proteins - metabolism Mutagenesis Mutation Peptide Fragments - metabolism S100 Proteins Spectrometry, Fluorescence
Online-Zugang:	Volltext
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